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Americaine Tube Of Ointment — prescription drug image

Americaine

Americaine 28GM of 20%

What is Americaine?

Americaine (benzocaine) is a topical anesthetic used to temporarily relieve pain and itching associated with minor burns, cuts, skin irritations, and insect bites. Available over-the-counter, it works by numbing the skin and surrounding area by blocking nerve signals in the body, providing fast-acting pain relief.

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What is Americaine ?

Americaine (benzocaine) is a topical anesthetic used to temporarily relieve pain and itching associated with minor burns, cuts, skin irritations, and insect bites. Available over-the-counter, it works by numbing the skin and surrounding area by blocking nerve signals in the body, providing fast-acting pain relief.
  • Redness, pain, or swelling where the medicine is applied
  • Confusion, headache, lightheadedness, shortness of breath, or fast heartbeat
  • Pale, gray, or blue skin, lips, or nails
  • Unusual tiredness or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Irritability, fainting, difficulty walking, or unusual drowsiness
  • Fast breathing
  • Unusual tiredness or weakness
  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, lung or breathing problems (such as asthma, bronchitis, or emphysema), or any blood disease.
  • Call your doctor if your symptoms get worse or do not improve within 7 days, or get better and then come back.
  • Do not give this medicine to a child younger than 2 years, unless directed by a doctor.
  • This medicine may cause a rare but serious blood problem called methemoglobinemia. This condition may occur after use of the spray for medical procedures or use of the over-the-counter gel or liquid for mouth sores or teething in children.
  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is Americaine used for?
Americaine is an OTC topical anesthetic spray and first-aid ointment containing benzocaine (20%). It's used to temporarily relieve pain and itching from minor burns, sunburn, insect bites, and minor cuts and scrapes.
Is Americaine spray safe to use?
When used as directed on intact skin for short-term, occasional relief, Americaine is generally considered safe for its labeled OTC use. However, benzocaine products carry an FDA warning about rare but serious methemoglobinemia, a blood disorder that reduces oxygen-carrying capacity, most associated with oral or mucosal use rather than skin application. Use it only on unbroken skin, avoid the eyes, don't exceed the labeled frequency, and stop use and seek medical attention if you notice pale, gray, or blue skin or lips, shortness of breath, rapid heart rate, confusion, or fatigue. This isn't medical advice — ask your pharmacist or doctor if you have questions about your specific situation.
Was Americaine recalled?
In December 2023, Insight Pharmaceuticals issued a voluntary nationwide recall of one specific lot of Americaine 20% Benzocaine Topical Anesthetic Spray after benzene contamination was detected. This was a lot-specific recall, not a permanent withdrawal of the product from the market.
What is the difference between Americaine and Solarcaine?
Both Americaine and Solarcaine are OTC sprays containing benzocaine as the active local anesthetic ingredient. Americaine is positioned as a general first-aid spray/ointment for minor burns, sunburn, insect bites, and cuts and scrapes, while Solarcaine is marketed specifically for sunburn relief. Check each product's label for its specific formulation and directions.
Can you use Americaine on a sunburn every day?
Americaine's label instructs against using it more often than directed (typically up to a few times a day) and says not to use it for more than a few days without consulting a doctor. If sunburn pain or irritation continues beyond a few days, or worsens, check with a doctor rather than continuing to apply it long-term.
How much does Americaine cost without insurance?
The price of Americaine without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Americaine?
Common side effects of Americaine may include: Redness, pain, or swelling where the medicine is applied, Confusion, headache, lightheadedness, shortness of breath, or fast heartbeat, Pale, gray, or blue skin, lips, or nails, Unusual tiredness or weakness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Americaine?
Generic versions may be available for Americaine. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Americaine on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Americaine?
The cheapest pharmacy for Americaine depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Americaine near you.

Americaine Coupons & Prices

Americaine 28GM of 20%

Americaine Tube Of Ointment — prescription drug image
Prescription
Americaine 20%, 28gm rectal ointment (1)
your area ·

Americaine prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
20%, 28gm rectal ointment · Tube Of Ointment 28 $9.74

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Americaine is an over-the-counter topical spray and first-aid ointment containing benzocaine (20%), a local anesthetic used to temporarily relieve pain and itching from minor burns, sunburn, insect bites, and minor cuts and scrapes; since it's available without a prescription, an americaine coupon can still help you compare pharmacy prices before you buy — enter your ZIP above to see today's price near you.

What Is Americaine and How Does It Work?

Americaine's active ingredient is benzocaine, an ester-type local anesthetic. Applied to the skin, it temporarily blocks nerve signals in the treated area, which is why it's used to relieve pain and itching from minor burns, sunburn, insect bites, and minor cuts or scrapes. It comes in spray and ointment forms meant for external, first-aid use on intact skin — not for eyes or broken/damaged skin.

A generic version of topical benzocaine is available, so pharmacies may carry both the Americaine brand and a lower-cost store-brand or generic equivalent with the same active ingredient and strength.

Comparing Prices and Saving on Americaine

Because Americaine is sold over the counter, you won't need insurance approval to buy it, but the price can still vary quite a bit from one pharmacy to the next. An americaine coupon through Rx.com lets you compare pharmacy prices in your area before you buy — enter your ZIP above to see today's price. It's also worth checking the price of the generic benzocaine spray or ointment side by side with the Americaine brand, since store-brand versions of the same 20% benzocaine formula are typically stocked next to it.

Prices vary by pharmacy and change frequently, so comparing before you buy is the most reliable way to find the better deal on any given day.

Americaine vs. Other Topical Anesthetics

Americaine (benzocaine) is one of several OTC options for numbing minor skin irritation. Solarcaine is another benzocaine-based spray marketed specifically for sunburn relief. Lidocaine is a different local anesthetic (an amide-type, rather than ester-type like benzocaine) sold in creams, patches, and sprays for similar minor pain and itch relief. Orajel is also benzocaine-based but is formulated and labeled for oral/dental use (teething and mouth sores), not skin application. Bactine combines a different anesthetic with an antiseptic for cleaning and numbing minor cuts and scrapes, and hydrocortisone is an anti-itch steroid cream rather than an anesthetic, often used for itching from insect bites or skin irritation without the numbing effect.

Which one makes sense depends on the type of irritation and the part of the body involved; a pharmacist can help you pick between them.

Safety Information

Benzocaine products, including Americaine, carry an FDA Drug Safety Communication warning about rare but serious and potentially life-threatening methemoglobinemia, a blood disorder that reduces the blood's ability to carry oxygen. Over 400 cases were reported to the FDA between 2009 and 2017. This risk is highest with oral or mucosal (mouth/gum) use and in infants and children under 2, for whom benzocaine oral products are not recommended; Americaine's topical skin spray and ointment are intended for external skin use only.

  • For external use only — avoid the eyes and broken or damaged skin.
  • Stop use and seek immediate medical attention if you notice signs of methemoglobinemia: pale, gray, or blue-colored skin or lips, shortness of breath, rapid heart rate, confusion, or fatigue.
  • Don't use more often than the label directs, and don't use for more than a few days without checking with a doctor.
  • In December 2023, the manufacturer (Insight Pharmaceuticals) issued a voluntary recall of one specific lot of Americaine 20% Benzocaine Topical Anesthetic Spray due to detected benzene contamination; this was limited to that lot, not a full market withdrawal.

This is general information, not medical advice — talk with your doctor or pharmacist about whether Americaine is right for you.

Sources & accuracy

This Americaine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Americaine on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.