Americaine
Americaine 28GM of 20%
What is Americaine?
Americaine (benzocaine) is a topical anesthetic used to temporarily relieve pain and itching associated with minor burns, cuts, skin irritations, and insect bites. Available over-the-counter, it works by numbing the skin and surrounding area by blocking nerve signals in the body, providing fast-acting pain relief.Side Effects
- Redness, pain, or swelling where the medicine is applied
- Confusion, headache, lightheadedness, shortness of breath, or fast heartbeat
- Pale, gray, or blue skin, lips, or nails
Warnings
- Unusual tiredness or weakness
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, lung or breathing problems (such as asthma, bronchitis, or emphysema), or any blood disease.
- Call your doctor if your symptoms get worse or do not improve within 7 days, or get better and then come back.
- Do not give this medicine to a child younger than 2 years, unless directed by a doctor.
- This medicine may cause a rare but serious blood problem called methemoglobinemia. This condition may occur after use of the spray for medical procedures or use of the over-the-counter gel or liquid for mouth sores or teething in children.
Prescription savings · · · ·
What is Americaine ?
Americaine (benzocaine) is a topical anesthetic used to temporarily relieve pain and itching associated with minor burns, cuts, skin irritations, and insect bites. Available over-the-counter, it works by numbing the skin and surrounding area by blocking nerve signals in the body, providing fast-acting pain relief.- Redness, pain, or swelling where the medicine is applied
- Confusion, headache, lightheadedness, shortness of breath, or fast heartbeat
- Pale, gray, or blue skin, lips, or nails
- Unusual tiredness or weakness
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Irritability, fainting, difficulty walking, or unusual drowsiness
- Fast breathing
- Unusual tiredness or weakness
- Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, lung or breathing problems (such as asthma, bronchitis, or emphysema), or any blood disease.
- Call your doctor if your symptoms get worse or do not improve within 7 days, or get better and then come back.
- Do not give this medicine to a child younger than 2 years, unless directed by a doctor.
- This medicine may cause a rare but serious blood problem called methemoglobinemia. This condition may occur after use of the spray for medical procedures or use of the over-the-counter gel or liquid for mouth sores or teething in children.
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Americaine Coupons & Prices
Americaine 28GM of 20%
Americaine prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 20%, 28gm rectal ointment · Tube Of Ointment | 28 | — | $9.74 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Americaine is an over-the-counter topical spray and first-aid ointment containing benzocaine (20%), a local anesthetic used to temporarily relieve pain and itching from minor burns, sunburn, insect bites, and minor cuts and scrapes; since it's available without a prescription, an americaine coupon can still help you compare pharmacy prices before you buy — enter your ZIP above to see today's price near you.
What Is Americaine and How Does It Work?
Americaine's active ingredient is benzocaine, an ester-type local anesthetic. Applied to the skin, it temporarily blocks nerve signals in the treated area, which is why it's used to relieve pain and itching from minor burns, sunburn, insect bites, and minor cuts or scrapes. It comes in spray and ointment forms meant for external, first-aid use on intact skin — not for eyes or broken/damaged skin.
A generic version of topical benzocaine is available, so pharmacies may carry both the Americaine brand and a lower-cost store-brand or generic equivalent with the same active ingredient and strength.
Comparing Prices and Saving on Americaine
Because Americaine is sold over the counter, you won't need insurance approval to buy it, but the price can still vary quite a bit from one pharmacy to the next. An americaine coupon through Rx.com lets you compare pharmacy prices in your area before you buy — enter your ZIP above to see today's price. It's also worth checking the price of the generic benzocaine spray or ointment side by side with the Americaine brand, since store-brand versions of the same 20% benzocaine formula are typically stocked next to it.
Prices vary by pharmacy and change frequently, so comparing before you buy is the most reliable way to find the better deal on any given day.
Americaine vs. Other Topical Anesthetics
Americaine (benzocaine) is one of several OTC options for numbing minor skin irritation. Solarcaine is another benzocaine-based spray marketed specifically for sunburn relief. Lidocaine is a different local anesthetic (an amide-type, rather than ester-type like benzocaine) sold in creams, patches, and sprays for similar minor pain and itch relief. Orajel is also benzocaine-based but is formulated and labeled for oral/dental use (teething and mouth sores), not skin application. Bactine combines a different anesthetic with an antiseptic for cleaning and numbing minor cuts and scrapes, and hydrocortisone is an anti-itch steroid cream rather than an anesthetic, often used for itching from insect bites or skin irritation without the numbing effect.
Which one makes sense depends on the type of irritation and the part of the body involved; a pharmacist can help you pick between them.
Safety Information
Benzocaine products, including Americaine, carry an FDA Drug Safety Communication warning about rare but serious and potentially life-threatening methemoglobinemia, a blood disorder that reduces the blood's ability to carry oxygen. Over 400 cases were reported to the FDA between 2009 and 2017. This risk is highest with oral or mucosal (mouth/gum) use and in infants and children under 2, for whom benzocaine oral products are not recommended; Americaine's topical skin spray and ointment are intended for external skin use only.
- For external use only — avoid the eyes and broken or damaged skin.
- Stop use and seek immediate medical attention if you notice signs of methemoglobinemia: pale, gray, or blue-colored skin or lips, shortness of breath, rapid heart rate, confusion, or fatigue.
- Don't use more often than the label directs, and don't use for more than a few days without checking with a doctor.
- In December 2023, the manufacturer (Insight Pharmaceuticals) issued a voluntary recall of one specific lot of Americaine 20% Benzocaine Topical Anesthetic Spray due to detected benzene contamination; this was limited to that lot, not a full market withdrawal.
This is general information, not medical advice — talk with your doctor or pharmacist about whether Americaine is right for you.
This Americaine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Americaine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.