Auvelity Coupons & Prices

Auvelity (dextromethorphan-bupropion) is a brand-name extended-release tablet approved for major depressive disorder in adults, and, more recently, for agitation associated with dementia due to Alzheimer's disease. If you're searching for an Auvelity coupon, it currently has no generic equivalent, so comparing pharmacy cash prices matters. Enter your ZIP above to see today's price near you.

What Is Auvelity and How Does It Work?

Auvelity combines dextromethorphan, an NMDA receptor antagonist and sigma-1 receptor agonist, with bupropion, which acts partly as a CYP2D6 inhibitor to raise dextromethorphan levels in the body. It's FDA-approved as extended-release tablets, taken by mouth, for the treatment of major depressive disorder (MDD) in adults. In 2026, the FDA also approved Auvelity for agitation associated with dementia due to Alzheimer's disease in adults — a separate, specific indication that doesn't extend to other causes of dementia-related agitation. It's not a controlled substance and isn't approved for use in children.

Manufacturer Savings Card vs. an Rx.com Cash Coupon

Auvelity's manufacturer, Axsome Therapeutics, offers an official savings and support program for eligible patients, but like most manufacturer copay programs, it's generally limited to people with commercial (private) insurance, and terms and eligibility vary and can change. It typically isn't available to patients on Medicare, Medicaid, or other government-funded insurance. An Rx.com cash coupon works differently — it can be used at the pharmacy counter regardless of insurance status, which is helpful if the manufacturer program doesn't apply to you.

There's currently no FDA-approved generic version of Auvelity, so comparing cash prices across pharmacies is one of the more reliable ways to find savings on the brand-name product.

Auvelity vs. Other Depression Treatments

• Bupropion (Wellbutrin and generic) — one of Auvelity's two active ingredients, available on its own as a lower-cost generic antidepressant, though it works differently than the combination product.
• SSRIs (such as sertraline or escitalopram, generic) — commonly prescribed first-line antidepressants with a different mechanism and side-effect profile.

Auvelity works faster for some patients than traditional antidepressants in clinical trials, but it isn't automatically the right choice for everyone — your prescriber will weigh your history, other medications, and side-effect tolerance.

Safety Information

Auvelity carries a boxed warning, standard for antidepressant medicines, about an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults; it is not approved for use in pediatric patients. Because it contains bupropion, Auvelity can increase the risk of seizures, and shouldn't be used by people with a seizure disorder or certain eating disorders. It can also raise blood pressure, and has been associated with activation of mania, psychosis, angle-closure glaucoma, and serotonin syndrome when combined with other serotonergic drugs — never combine it with an MAOI. This isn't a complete list of risks; talk with your prescriber or pharmacist about your full health history before starting Auvelity.