What is Estrace ?

Estradiol is a synthetic form of the naturally occurring female hormone estrogen, primarily used in hormone replacement therapy for managing symptoms associated with menopause, such as hot flashes and vaginal dryness, and in certain cases of estrogen deficiency. It functions by replenishing declining estrogen levels, thereby helping maintain various physiological processes including reproductive health and bone density. Estradiol is available in various forms, including oral tablets, transdermal patches, and topical applications, allowing for flexible administration based on patient needs.

• Nausea
• Headache
• Breast tenderness
• Weight changes
• Mood changes
• Abdominal cramping or bloating
• Swelling in hands or feet
• Vaginal spotting or breakthrough bleeding
• Increased or decreased libido

• Increased risk of endometrial cancer in women with an intact uterus using unopposed estrogen
• Increased risk of thromboembolic events, including stroke and deep vein thrombosis
• Possible increased risk of breast cancer with prolonged use
• Use with caution in people with liver impairment or disease
• May cause elevated blood pressure
• Not recommended during pregnancy or breastfeeding
• May exacerbate hormone-sensitive conditions (e.g., certain types of cancers)
• History of depression: monitor patients closely