Fluoxetine Hcl (Pmdd)
FLUoxetine HCl (PMDD) 10MG
What is Fluoxetine Hcl (Pmdd)?
Sarafem is a selective serotonin reuptake inhibitor drug used to treat women diagnosed with premenstrual dysphoric disorder (PMDD). Fluoxetine is the generic version of Sarafem. Sarafem costs around $289 for a supply of 10, 10 mg tablets, but luckily there are ways to save money. You can use our Rx.com Sarafem savings card to save significantly on the retail price at participating pharmacies near you.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Changes in behavior, thoughts of hurting yourself or others
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, glaucoma, or a history of seizures. Tell your doctor if you have had heart disease, a heart rhythm problem (including QT prolongation), heart attack, heart failure, low blood pressure, or a stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongationSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Fluoxetine Hcl (Pmdd) ?
Sarafem is a selective serotonin reuptake inhibitor drug used to treat women diagnosed with premenstrual dysphoric disorder (PMDD). Fluoxetine is the generic version of Sarafem. Sarafem costs around $289 for a supply of 10, 10 mg tablets, but luckily there are ways to save money. You can use our Rx.com Sarafem savings card to save significantly on the retail price at participating pharmacies near you.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Changes in behavior, thoughts of hurting yourself or others
- Confusion, weakness, muscle twitching
- Eye pain, vision changes, seeing halos around lights
- Fast, pounding, or uneven heartbeat, dizziness
- Unusual bleeding or bruising
- Unusual bleeding or bruising
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Trouble keeping still, feeling restless and agitated, racing thoughts, excessive energy, trouble sleeping
- Unusual bleeding or bruising
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, glaucoma, or a history of seizures. Tell your doctor if you have had heart disease, a heart rhythm problem (including QT prolongation), heart attack, heart failure, low blood pressure, or a stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongationSexual problems
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Skin rash, blisters, peeling, or redness
- Trouble breathing
- Unusual behavior, thoughts of hurting yourself or others
- Unusual bleeding or bruising
Fluoxetine Hcl (Pmdd) Coupons & Prices
FLUoxetine HCl (PMDD) 10MG
Fluoxetine hydrochloride is an SSRI antidepressant that's also FDA-approved to treat premenstrual dysphoric disorder (PMDD), the severe form of PMS. It's sold as a generic by multiple manufacturers, and cash prices for the same strength can differ a lot by pharmacy — enter your ZIP above to see today's price and find a fluoxetine coupon nearby.
What is fluoxetine and how does it treat PMDD?
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI). Beyond its use for depression, fluoxetine is FDA-approved to treat premenstrual dysphoric disorder — a condition marked by significant mood, irritability, and physical symptoms in the days before a menstrual period. For PMDD, fluoxetine can be taken continuously or, for some patients, only during the luteal phase (the second half of the cycle) as directed by a prescriber. The brand once specifically marketed for PMDD, Sarafem, is no longer sold in the U.S.; generic fluoxetine capsules and tablets carrying the PMDD indication are what's available today.
Cost without insurance
Generic fluoxetine is widely available, but prices still vary by pharmacy, strength, and quantity dispensed. Comparing cash prices matters even for a common generic like this one. Rx.com compares fluoxetine prices across more than 60,000 U.S. pharmacies so you can find a lower price nearby, with or without insurance.
Fluoxetine vs. other PMDD treatment options
- Sertraline is another SSRI that's FDA-approved for PMDD and is commonly used as an alternative.
- Drospirenone/ethinyl estradiol (Yaz) is a combined oral contraceptive that's FDA-approved specifically for PMDD in women who choose an oral contraceptive for birth control.
- Some prescribers also use other SSRIs off-label for PMDD symptoms; your prescriber can help weigh the options based on your symptoms and health history.
Safety information
Fluoxetine and other antidepressants carry a boxed warning: they can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults under 24, especially during the first months of treatment or after a dose change. Anyone taking fluoxetine should be watched for worsening mood, unusual behavior changes, or new or worsening suicidal thoughts, and family members should be told to report these promptly. This is general information, not medical advice — talk with a doctor before starting or stopping fluoxetine, and never stop it abruptly without medical guidance.
This Fluoxetine Hcl (Pmdd) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Fluoxetine Hcl (Pmdd) on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.