Ondansetron Coupons & Prices

Looking for an ondansetron coupon? Ondansetron is the low-cost generic version of Zofran, a prescription medicine used to prevent nausea and vomiting. Because it is a widely available generic, the cash price is already modest at most pharmacies, but the amount you pay can still vary a lot from one pharmacy to the next. Rx.com compares live ondansetron prices across more than 60,000 U.S. pharmacies so you can find the lowest price near you. Enter your ZIP above to see today's price and print or show a free coupon at the pharmacy counter.

What is ondansetron and how does it work?

Ondansetron is a serotonin 5-HT3 receptor antagonist, a class of medicine known as antiemetics (drugs that prevent nausea and vomiting). It is the active ingredient in the brand-name products Zofran, Zofran ODT, and Zuplenz. It works by blocking the action of serotonin, a natural substance in the body that can trigger the vomiting reflex. It comes as a regular tablet, an orally disintegrating tablet (ODT) that melts on the tongue, and a liquid.

Ondansetron is FDA-approved to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery (postoperative nausea and vomiting). It is a prescription medicine and is not a controlled substance.

Ondansetron cost and coupons without insurance

Ondansetron is available as a generic, which means it is usually one of the more affordable prescriptions even without insurance. That said, generic prices are not the same everywhere. The cash price for the same tablet count can differ widely between two nearby pharmacies, so it pays to compare before you fill. A free Rx.com coupon can often bring the cash price below what you would pay at the register.

Rx.com checks live prices at more than 60,000 pharmacies and shows you the lowest option in your area. Enter your ZIP above to see today's price. The coupon is free to use, works whether or not you have insurance, and there is no membership required. If your doctor prescribed brand-name Zofran, ask whether the generic is appropriate for you, since it typically costs far less.

Ondansetron alternatives and related medicines

Ondansetron is one of several medicines used to control nausea and vomiting. If it is not the right fit for you, your provider may consider an alternative. Related antiemetics include:

• Granisetron — another 5-HT3 receptor antagonist in the same class as ondansetron.
• Promethazine — an antihistamine-type antiemetic used for nausea and motion sickness.
• Prochlorperazine — used for severe nausea and vomiting.
• Metoclopramide — used for nausea and certain stomach and digestive problems.

Each of these works differently and has its own risks and benefits. Only your prescriber can decide which is best for your situation.

Ondansetron safety and side effects

This is general information, not medical advice — always follow your prescriber's and pharmacist's guidance. The most common side effects of ondansetron include headache, constipation, tiredness, and dizziness. A more serious concern is that ondansetron can cause dose-dependent QT-interval prolongation, a change in the heart's electrical rhythm that can rarely lead to a dangerous arrhythmia called Torsades de Pointes. Because of this, it should be used with caution, or avoided, in people with congenital long QT syndrome, heart failure, slow heart rhythms, or low potassium or magnesium levels.

Tell your provider about all medicines you take. Ondansetron should not be used with apomorphine, as the combination can cause a severe drop in blood pressure. Combining ondansetron with other serotonergic drugs (such as SSRIs, SNRIs, or MAOIs) raises the risk of serotonin syndrome. Allergic reactions, including anaphylaxis, have been reported. The orally disintegrating tablets contain phenylalanine (from aspartame), so they should be used with caution by anyone with phenylketonuria (PKU). Seek medical help right away for chest pain, fainting, an irregular heartbeat, agitation or confusion, or signs of an allergic reaction.