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Simbrinza

Simbrinza

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What is Simbrinza?

Simbrinza (brinzolamide/brimonidine) is a prescription eye drop used to lower elevated eye pressure in people with open-angle glaucoma or ocular hypertension. It combines two medications that work together to reduce intraocular pressure, helping protect the optic nerve and lower the risk of vision loss.

Prescription savings · · · ·

What is Simbrinza ?

Simbrinza (brinzolamide/brimonidine) is a prescription eye drop used to lower elevated eye pressure in people with open-angle glaucoma or ocular hypertension. It combines two medications that work together to reduce intraocular pressure, helping protect the optic nerve and lower the risk of vision loss.

  • Severe eye redness, pain, or swelling, sensitivity to light
  • Unusual bleeding, bruising, or weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Ongoing or severe blurred vision or other changes in vision
  • Yellowing of your skin or the whites of your eyes
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, depression, heart or blood vessel disease, low blood pressure, an eye infection, or other eye problems.
  • This medicine may cause serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.
  • This medicine may cause blurred vision or other vision problems. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is Simbrinza used to treat?
Simbrinza is used to lower elevated intraocular pressure (the fluid pressure inside the eye) in adults who have open-angle glaucoma or ocular hypertension. Keeping that pressure down helps protect the optic nerve and preserve vision.
How many times a day do you use Simbrinza eye drops?
The usual dose is 1 drop in the affected eye or eyes 3 times a day. Shake the bottle before use and follow your eye doctor's specific instructions.
Is there a generic version of Simbrinza available?
No. There is currently no generic version of Simbrinza (brinzolamide/brimonidine). Its individual ingredients are available as generics separately, such as brinzolamide and brimonidine, but the combination drop itself is brand-only. Because of that, comparing cash prices with a discount coupon is often the best way to save.
What are the most common side effects of Simbrinza?
The most common side effects are blurred vision, eye irritation or allergic conjunctivitis, red eye, a bitter or unusual taste in the mouth, and dry mouth. Contact your doctor if side effects are severe or do not go away.
Can you wear contact lenses while using Simbrinza?
You should not wear contact lenses while your eyes are being treated. Simbrinza contains benzalkonium chloride, which can be absorbed by soft contacts, so remove your lenses before putting in the drops and wait at least 15 minutes before reinserting them.
How much does Simbrinza 8ML of 1-0.2% cost without insurance?
The price of Simbrinza 8ML of 1-0.2% without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Simbrinza 8ML of 1-0.2%?
Common side effects of Simbrinza 8ML of 1-0.2% may include: Severe eye redness, pain, or swelling, sensitivity to light, Unusual bleeding, bruising, or weakness, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Blistering, peeling, red skin rash, Ongoing or severe blurred vision or other changes in vision. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Simbrinza 8ML of 1-0.2%?
Generic versions may be available for Simbrinza 8ML of 1-0.2%. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Simbrinza 8ML of 1-0.2% on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Simbrinza 8ML of 1-0.2%?
The cheapest pharmacy for Simbrinza 8ML of 1-0.2% depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Simbrinza 8ML of 1-0.2% near you.

Simbrinza Coupons & Prices

Simbrinza

Prescriptions & Refills
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Simbrinza Bottle — prescription drug image
Prescription
Simbrinza 8ml of 1-0.2% (1)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Simbrinza coupon? Rx.com offers a free cash discount coupon for Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension), the brand-name eye drop that lowers elevated pressure inside the eye in people with open-angle glaucoma or ocular hypertension. Because there is no generic version yet, Simbrinza can be costly at the pharmacy counter, so it pays to compare. Enter your ZIP above to see today's price and print or show your Rx.com coupon at the pharmacy.

What is Simbrinza and how does it work?

Simbrinza is a prescription eye drop that combines two medicines in one bottle to reduce elevated intraocular pressure (the fluid pressure inside the eye) in adults with open-angle glaucoma or ocular hypertension. Lowering that pressure helps protect the optic nerve from damage that can lead to vision loss over time.

The two active ingredients work in different ways. Brinzolamide is a carbonic anhydrase inhibitor that reduces how much fluid (aqueous humor) the eye makes. Brimonidine is an alpha-2 adrenergic agonist that both reduces fluid production and helps more fluid drain out of the eye. Because the mechanisms are complementary, the fixed-dose combination can lower pressure more than either ingredient alone. The usual dose is 1 drop in the affected eye or eyes 3 times a day. Always follow your eye doctor's specific instructions.

Simbrinza cost: manufacturer savings card vs. Rx.com cash coupon

The manufacturer, Alcon, runs an official Simbrinza savings program (details are on the manufacturer's own website). Copay savings cards like this are generally limited to people with commercial (private) insurance, and the terms, eligibility, and any caps vary and can change. Patients with Medicare, Medicaid, or other government coverage typically do not qualify, and neither do people who are uninsured.

That is where the Rx.com cash coupon helps. It is a discount coupon you can use whether you are uninsured, on Medicare, or if the manufacturer card is declined at the pharmacy. You simply pay the discounted cash price instead of billing insurance. There is no generic version of Simbrinza available, so shopping the cash price is often the biggest lever you have for savings on this specific drug. Prices differ by pharmacy and location, so enter your ZIP above to see today's price and compare before you fill.

Simbrinza alternatives and related glaucoma eye drops

Simbrinza has no direct generic, but its two ingredients are also available separately and in other combinations, some of which do have generics. Your eye doctor decides what fits your treatment plan, but common related options include:

  • The two components on their own: Azopt and its generic brinzolamide, and Alphagan and its generic brimonidine.
  • Other fixed-dose combination drops such as Combigan (brimonidine/timolol), Cosopt and generic dorzolamide-timolol.
  • A prostaglandin drop such as latanoprost, which lowers eye pressure by a different mechanism.

If a generic version of one of these is a fit for you, it can be a much cheaper option, so it is worth asking your provider. This is general information, not medical advice.

Simbrinza safety and side effects

Simbrinza has no boxed warning, but there are important precautions. It is contraindicated in newborns and infants under 2 years of age, because brimonidine can cause serious central nervous system effects such as drowsiness or slowed breathing (apnea) in very young children. It can also cause drowsiness or fatigue in adults and can add to the effects of alcohol and CNS depressants (such as sedatives, opioids, and barbiturates), so use caution driving or operating machinery. Brinzolamide is a sulfonamide ("sulfa") medicine, so serious sulfa-type reactions are possible; stop the drops and get medical help if you notice signs of a severe reaction. Simbrinza should not be used with MAO inhibitor antidepressants, and caution is advised with tricyclic antidepressants and blood pressure or heart medicines.

The most common side effects are blurred vision, eye irritation or allergic conjunctivitis, red eye (ocular hyperemia), a bitter or unusual taste, and dry mouth. Do not wear contact lenses while your eyes are being treated; the drops contain benzalkonium chloride, so remove lenses before use and wait 15 minutes before putting them back in. Tell your doctor if you have severe kidney or liver problems, serious heart or circulation conditions, or depression. This is a summary, not a complete list. Read the label and talk with your doctor or pharmacist about your full health history.

Sources & accuracy

This Simbrinza information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Simbrinza on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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