What is Truxima ?

Truxima (rituximab-abbs) is a monoclonal antibody biosimilar to Rituxan, indicated for the treatment of adult patients with certain types of non-Hodgkin lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis, and microscopic polyangiitis. Truxima works by targeting the CD20 antigen on the surface of pre-B and mature B-lymphocytes, leading to their destruction and helping to manage symptoms and progression of these autoimmune diseases and cancers.

• Confusion, body weakness, numbness or tingling in your hands, feet, or lips
• Dizziness, lightheadedness, drowsiness
• Problems with vision, coordination, or speech
• Sores, ulcers, or white spots in the mouth or on the lips
• Decrease in how much or how often you urinate, pain while urinating
• Chest pain, uneven heartbeat, sudden fainting
• Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed
• Unusual bleeding, bruising, or weakness
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow eyes or skin
• Unusual tiredness or weakness
• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Bloody vomit or vomit that looks like coffee grounds, severe stomach pain
• Rapid weight gain, swelling in your hands, ankles, or feet
• Fever, chills, cough, sore throat, body aches
• Unusual bleeding or bruising

• Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. If you are a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before giving you this medicine. Use an effective form of birth control during treatment with this medicine and for at least 12 months after your last dose.
• Do not breastfeed during treatment with this medicine and for at least 6 months after the last dose.
• Tell your doctor if you have kidney disease, liver disease (including hepatitis B), chest pain (angina), heart disease, lung problems, immune system problems (including hypogammaglobulinemia), any type of infection, or a history of chest pain (angina) or heart rhythm problems.
• This medicine may cause the following problems:Infusion reactionSerious skin and mouth reactions (including paraneoplastic pemphigus, Stevens-Johnson syndrome, lichenoid dermatitis, vesiculobullous dermatitis, and toxic epidermal necrolysis)Progressive multifocal leukoencephalopathy (brain infection that can be life-threatening)Tumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)Increased risk of serious infectionsHeart and heart rhythm problemsKidney problemsBowel problems (including blockage and perforation)
• Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Call your doctor right away if you have a cough that won't go away, weight loss, night sweats, fever, chills, flu-like symptoms (such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill), painful or difficult urination, or sores, ulcers, or white spots in the mouth or on the lips. These may be signs of infection.
• This medicine may cause a rare and serious brain infection called progressive multifocal leukoencephalopathy (PML). The risk for getting this infection is higher if you have rheumatoid arthritis. Check with your doctor right away if you have more than one of these symptoms: vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, and weakness in the legs.
• Check with your doctor right away if you have any symptoms of liver problems, including yellow skin and eyes, dark urine or pale stools, nausea and vomiting, or upper stomach pain.
• Check with your doctor right away if you have abdominal pain. This medicine could cause serious stomach and bowel problems, such as a bowel obstruction or a hole in your bowel.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Rapid weight gain, swelling in your hands, ankles, or feet
• Sores, ulcers, or white spots in the mouth or on the lips
• Unusual bleeding or bruising
• Unusual tiredness or weakness