Etoposide
Etoposide 50MG
What is Etoposide?
Etoposide is a generic drug that is used to treat patients diagnosed with small-cell lung cancer. The average price for Etoposide is about $16 for a supply of 5 milliliters, 20 mg/mL intravenous solution. You can use our Rx.com savings offer to get an Etoposide discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Swelling in your face, mouth, or tongue.
- Unusual bleeding or bruising.
- Seizures or tremors.
Warnings
- Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, any type of infection, or a history of low albumin (plasma protein).
- This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have chills, fever, lightheadedness, dizziness, fainting, fast heartbeat, swelling of the face, tongue, or throat, or trouble with breathing after taking the medicine.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may cause leukemia (cancer of the blood or bone marrow) in rare cases. Talk with your doctor about any concerns you have about this.
Prescription savings · · · ·
What is Etoposide ?
Etoposide is a generic drug that is used to treat patients diagnosed with small-cell lung cancer. The average price for Etoposide is about $16 for a supply of 5 milliliters, 20 mg/mL intravenous solution. You can use our Rx.com savings offer to get an Etoposide discount of up to 80% off of the retail price at participating pharmacies near you.- Swelling in your face, mouth, or tongue.
- Unusual bleeding or bruising.
- Seizures or tremors.
- Unusual tiredness or weakness.
- Trouble with swallowing.
- Severe diarrhea.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Yellowing of your skin or the whites of your eyes.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash.
- Blood in the urine or stools.
- Blue fingernails, lips, skin, palms, or nail beds.
- Blurred vision or changes in vision.
- Confusion, restlessness, or loss of consciousness.
- Fast, slow, pounding, or uneven heartbeat.
- Increased sweating, or shivering.
- Lightheadedness, dizziness, or fainting.
- Painful mouth sores that keep you from drinking liquids.
- Shortness of breath, trouble with breathing, chest or throat tightness, or wheezing.
- Unexplained fever, chills, cough, or sore throat.
- Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, any type of infection, or a history of low albumin (plasma protein).
- This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have chills, fever, lightheadedness, dizziness, fainting, fast heartbeat, swelling of the face, tongue, or throat, or trouble with breathing after taking the medicine.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- This medicine may cause leukemia (cancer of the blood or bone marrow) in rare cases. Talk with your doctor about any concerns you have about this.
- This medicine may make your mouth sore and irritated. Brush your teeth with a soft-bristle toothbrush or mouth swab.
- Oral routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen. If the medicine does not help (you can't keep liquids down), call your doctor.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Lightheadedness, dizziness, or fainting.
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
- Painful mouth sores that keep you from drinking liquids.
- Seizures or tremors.
- Severe diarrhea.
- Shortness of breath, trouble with breathing, chest or throat tightness, or wheezing.
- Swelling in your face, mouth, or tongue.
- Trouble with swallowing.
- Unexplained fever, chills, cough, or sore throat.
- Unusual bleeding or bruising.
- Unusual tiredness or weakness.
- Yellowing of your skin or the whites of your eyes.
Etoposide Coupons & Prices
Etoposide 50MG
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Looking for an etoposide coupon? Etoposide is a generic chemotherapy medicine, so it already costs far less than the discontinued brand versions (Vepesid and Toposar). Even so, the cash price can vary widely from one pharmacy to the next, which is why comparing before you fill matters. Rx.com checks prices across more than 60,000 U.S. pharmacies so you can find a lower price near you. Enter your ZIP above to see today's etoposide price and print or show a free coupon at the pharmacy.
What is etoposide and how does it work?
Etoposide is a chemotherapy medicine in a group called topoisomerase II inhibitors (it is a podophyllotoxin derivative, a type of plant alkaloid chemotherapy agent). It works by interfering with an enzyme that cancer cells need to copy and repair their DNA, which helps stop the cells from growing and dividing. It is FDA-approved to treat small cell lung cancer (SCLC), usually combined with other chemotherapy drugs, and refractory testicular tumors in combination after surgery, other chemotherapy, and radiation have been tried.
The brand names Vepesid and Toposar have been discontinued, so treatment today generally uses the generic. A closely related medicine, etoposide phosphate, is sold under the brand Etopophos. Etoposide is given in a hospital or infusion center by a care team, not something you start on your own.
Etoposide cost and coupons without insurance
Because etoposide is available as a generic, it is typically much more affordable than the brand-name versions once were. That said, cash prices are not the same everywhere; the same prescription can cost noticeably more at one pharmacy than at another down the street. Comparing pharmacies is the simplest way to avoid overpaying, especially if you do not have insurance or your plan does not cover the full cost.
Rx.com shows live, up-to-date pricing from more than 60,000 pharmacies and provides a free discount coupon you can use at the counter. Prices change often, so we do not list a fixed dollar amount here. Enter your ZIP above to see today's etoposide price near you and compare your options before you fill.
Etoposide vs. related medicines
Etoposide is almost always used as part of a combination regimen rather than on its own. In many small cell lung cancer and testicular cancer treatment plans it is paired with a platinum chemotherapy drug such as cisplatin or carboplatin. These are different medicines that work in different ways, and your oncologist chooses the combination based on your specific diagnosis.
If your prescription calls for the related intravenous form etoposide phosphate, you can compare pricing for Etopophos as well. Your care team decides which form is right for you; use Rx.com to compare the cash price on whichever one you are prescribed.
Etoposide safety and side effects
Etoposide carries a boxed warning and must be given under the supervision of a physician experienced in cancer chemotherapy. Its main dose-limiting risk is severe myelosuppression (low white cells, platelets, and red cells), which can lead to serious infection or bleeding, so your blood counts are monitored closely. Other important risks include allergic-type infusion reactions (such as a drop in blood pressure or trouble breathing), which is why it is infused slowly, along with severe nausea and vomiting, hair loss, and mouth sores. There is also a small risk of a treatment-related second cancer (a form of leukemia), and it can harm an unborn baby, so it is avoided in pregnancy. People with reduced kidney function may need a lower dose.
This is general information, not medical advice. Your oncology team will explain the specific risks and monitoring for your situation. Tell them about all your other medicines and any health conditions, and report new symptoms such as fever, unusual bruising or bleeding, or signs of an allergic reaction right away.
This Etoposide information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Etoposide on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.