Letrozole
Letrozole 2.5MG
What is Letrozole?
Letrozole (Femara) is a prescription medication used to treat certain types of hormone receptor-positive breast cancer in postmenopausal women. It is also commonly prescribed off-label to help induce ovulation in women experiencing infertility related to conditions such as polycystic ovary syndrome (PCOS).
Side Effects
- Unusual bleeding or bruising.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bone pain
Warnings
- Unusual tiredness or weakness.
- Vaginal discharge, bleeding, or dryness.
- Oral routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for at least 3 weeks after the last dose.
- Do not breastfeed while you are taking this medicine and for at least 3 weeks after your last dose.
- Tell your doctor if you have liver disease (including cirrhosis), bone problems (including osteoporosis), or high cholesterol in the blood.
Prescription savings · · · ·
What is Letrozole ?
Letrozole (Femara) is a prescription medication used to treat certain types of hormone receptor-positive breast cancer in postmenopausal women. It is also commonly prescribed off-label to help induce ovulation in women experiencing infertility related to conditions such as polycystic ovary syndrome (PCOS).
- Unusual bleeding or bruising.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bone pain
- Chest pain, trouble breathing, coughing up blood
- Dark urine, pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Pain in your lower leg (calf)
- Swelling in your ankles or feet
- Unusual bleeding or bruising
- Unusual tiredness or weakness
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your ankles or feet.
- Vaginal discharge, bleeding, or dryness.
- Unusual tiredness or weakness.
- Unusual tiredness or weakness.
- Vaginal discharge, bleeding, or dryness.
- Oral routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control during treatment with this medicine and for at least 3 weeks after the last dose.
- Do not breastfeed while you are taking this medicine and for at least 3 weeks after your last dose.
- Tell your doctor if you have liver disease (including cirrhosis), bone problems (including osteoporosis), or high cholesterol in the blood.
- This medicine may cause the following problems:Low bone mineral densityHigh cholesterol or fat levels in the bloodLiver problems
- This medicine may make you dizzy, drowsy, or tired. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Oral routeThis medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your ankles or feet.
- Unusual bleeding or bruising.
Letrozole Coupons & Prices
Letrozole 2.5MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a letrozole coupon? Letrozole is the low-cost generic version of Femara, and because it is available as a generic it is already one of the more affordable options in its class. Even so, the cash price for the same tablet can vary widely from one pharmacy to the next, so comparing before you fill can make a real difference. Rx.com compares live letrozole prices across more than 60,000 U.S. pharmacies. Enter your ZIP above to see today's price and print or show a free discount coupon at the pharmacy counter.
What is letrozole and how does it work?
Letrozole is a nonsteroidal aromatase inhibitor. It is FDA-approved to treat hormone receptor-positive (or unknown-receptor) early breast cancer in postmenopausal women. This includes adjuvant treatment, extended adjuvant treatment after 5 years of tamoxifen, first-line treatment of hormone-dependent advanced or metastatic breast cancer, and second-line treatment of advanced breast cancer that has progressed on antiestrogen therapy. It works by blocking the aromatase enzyme, which lowers the amount of estrogen the body makes. For hormone-sensitive breast cancers, less estrogen can slow or stop the tumor's growth.
Letrozole is also very commonly used off-label for ovulation induction in women being treated for infertility, especially those with polycystic ovary syndrome (PCOS). Whether letrozole is right for your situation is a decision to make with your doctor.
What does letrozole cost without insurance?
Because letrozole is available as a generic, it is typically much less expensive than the brand-name version, and it is one of the lower-cost medicines in its category. That said, the cash price without insurance is not the same everywhere. Two pharmacies in the same town can charge noticeably different amounts for the identical prescription, which is exactly why comparing prices is worth the few seconds it takes.
Rx.com checks the current cash price across more than 60,000 pharmacies and shows you a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you. Prices update regularly, so it is best to check at the time you fill.
Letrozole vs. Femara and other alternatives
Letrozole is the generic form of Femara. The two contain the same active ingredient and are used the same way; the generic simply costs less. If your prescription says Femara, ask your pharmacist whether the generic letrozole is an option for you.
Letrozole belongs to the aromatase inhibitor family, which also includes anastrozole and exemestane. Another common hormone therapy for breast cancer is tamoxifen, which works differently. For fertility use, clomiphene is a related option. Your doctor chooses among these based on your specific situation. If you are prescribed any of them, you can compare prices for each on Rx.com.
Safety and side effects to know
The most common side effects of letrozole include hot flashes, joint and muscle pain (arthralgia), night sweats, fatigue, and nausea. It can also cause dizziness and drowsiness, so use caution driving or operating machinery until you know how it affects you. Over time, letrozole can lower bone mineral density and increase the risk of osteoporosis and fractures, and it may raise total and LDL cholesterol. Rarely, serious liver problems or allergic reactions such as swelling (angioedema) have been reported.
Letrozole must not be used during pregnancy or by premenopausal women when taken for breast cancer, because it can harm a developing baby. This is general information, not medical advice. Talk with your doctor or pharmacist about your full health history, other medicines you take, and any side effects you notice.
This Letrozole information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Letrozole on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.