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Tri-Sprintec Disp Pack — prescription drug image

Tri-Sprintec

Tri-Sprintec 28 Tablets

Women's Health Care
Licensed US providers · Online visit in minutes

What is Tri-Sprintec?

Tri-Sprintec is a combination birth control pill used to help prevent pregnancy. It contains norgestimate and ethinyl estradiol and may also be prescribed to regulate menstrual cycles, reduce acne, and manage certain hormonal symptoms. Learn about Tri-Sprintec uses, effectiveness, side effects, dosage, and important safety information.

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What is Tri-Sprintec ?

Tri-Sprintec is a combination birth control pill used to help prevent pregnancy. It contains norgestimate and ethinyl estradiol and may also be prescribed to regulate menstrual cycles, reduce acne, and manage certain hormonal symptoms. Learn about Tri-Sprintec uses, effectiveness, side effects, dosage, and important safety information.

  • Nausea
  • Vomiting
  • Headache
  • Bloating
  • Swelling of the ankles/feet (fluid retention)
  • Weight change
  • Breast tenderness
  • Blood clots
  • Stroke
  • High blood pressure
  • Heart attacks
  • Changes in vaginal bleeding
  • Liver problems such as liver tumors
Is Tri-Sprintec the same as Ortho Tri-Cyclen?
Yes. Tri-Sprintec is the generic equivalent of the reference brand Ortho Tri-Cyclen. Both are triphasic combination pills that contain the same active ingredients, norgestimate and ethinyl estradiol. The generic is typically much less expensive.
What is Tri-Sprintec used for besides birth control?
Besides preventing pregnancy, Tri-Sprintec is FDA-approved to treat moderate acne vulgaris in females at least 15 years old who have started menstruating, have no contraindications to oral contraceptives, and want to use an oral contraceptive for birth control. Some providers also prescribe it for other reasons based on your situation, so ask your provider what applies to you.
How long does it take for Tri-Sprintec to become effective?
The timing depends on when in your cycle you start and the method your provider recommends, so it is not the same for everyone. Follow the start-day instructions your provider or pharmacist gives you, and ask whether you need a backup method of birth control during your first days on the pill.
What are the most common side effects of Tri-Sprintec?
Combination birth control pills like Tri-Sprintec can cause side effects such as nausea, breast tenderness, headaches, spotting between periods, and mood changes. Serious but less common risks include blood clots, stroke, and heart attack, which are higher in smokers and women over 35. Review the full list with your pharmacist and contact your provider about anything that concerns you.
What is the difference between Tri-Sprintec and Tri-Lo-Sprintec?
Both are triphasic pills with norgestimate and ethinyl estradiol, but Tri-Lo-Sprintec is a lower-estrogen version. Which one is right for you depends on your health history and your provider's recommendation, so discuss any change with them.
How much does Tri-Sprintec 28 Tablets cost without insurance?
The price of Tri-Sprintec 28 Tablets without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Tri-Sprintec 28 Tablets?
Common side effects of Tri-Sprintec 28 Tablets may include: Nausea, Vomiting, Headache, Bloating, Swelling of the ankles/feet (fluid retention). This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Tri-Sprintec 28 Tablets?
Generic versions may be available for Tri-Sprintec 28 Tablets. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Tri-Sprintec 28 Tablets on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Tri-Sprintec 28 Tablets?
The cheapest pharmacy for Tri-Sprintec 28 Tablets depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Tri-Sprintec 28 Tablets near you.

Tri-Sprintec Coupons & Prices

Tri-Sprintec 28 Tablets

Women's Health Care
Licensed US providers · Online visit in minutes
Tri-Sprintec Disp Pack — prescription drug image
Prescription
Tri-Sprintec 1 package (28 tablets), 0.18-35/0.215-35/0.25-35mg-mcg (1)
your area ·
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a Tri-Sprintec coupon? Tri-Sprintec is the generic version of Ortho Tri-Cyclen, a triphasic combination birth control pill containing norgestimate and ethinyl estradiol. Because it is available as a generic, it is already one of the more affordable oral contraceptives, but the cash price can vary widely from one pharmacy to the next. Rx.com compares prices across more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price at pharmacies close to you.

What is Tri-Sprintec and how does it work?

Tri-Sprintec is a combination oral contraceptive that pairs a progestin (norgestimate) with an estrogen (ethinyl estradiol). It uses a triphasic regimen, meaning the hormone dose changes across three phases of the monthly pack to more closely follow a natural cycle. It is the generic equivalent of the reference brand Ortho Tri-Cyclen, and it is also sold under other equivalent branded generics such as Tri-Linyah, Tri-Estarylla, Tri-Mili, Tri-Femynor, and Tri-VyLibra.

Tri-Sprintec is FDA-approved to prevent pregnancy in females of reproductive potential. It is also FDA-approved to treat moderate acne vulgaris in females at least 15 years old who have started menstruating, have no contraindications to oral contraceptive therapy, and want to use an oral contraceptive for birth control. Some providers also prescribe it to help regulate menstrual cycles or manage related symptoms; talk with your provider about whether it fits your needs.

Tri-Sprintec cost without insurance and how to save

As a generic, Tri-Sprintec is typically much less expensive than brand-name Ortho Tri-Cyclen, but there is no single set price. What you pay in cash can differ significantly between pharmacies, even within the same town, which is exactly why comparing prices matters. There is no manufacturer savings card for Tri-Sprintec because it is a generic.

To find the lowest price, enter your ZIP above to see today's price at nearby pharmacies and use the Rx.com coupon at checkout. Rx.com compares cash prices across more than 60,000 pharmacies, so you can quickly see where the drug costs less. Coupon prices are cash prices and do not use your insurance; sometimes a discount coupon beats an insurance copay, so it can be worth comparing both.

Tri-Sprintec vs. related pills and alternatives

Tri-Sprintec is the generic of the reference brand Ortho Tri-Cyclen. If you are comparing similar options, a few related pills use the same or a similar mix of norgestimate and ethinyl estradiol:

These are not interchangeable at your own discretion. Which pill is right for you depends on your health history and your provider's guidance, so review any switch with them first.

Important safety information

Tri-Sprintec carries a boxed warning: cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives, and that risk rises with age and heavy smoking. Women over 35 who smoke should not use it. Combination birth control pills can also increase the risk of blood clots (including DVT and PE), stroke, and heart attack, especially during the first year of use and after restarting. It is not appropriate for people who are pregnant or who have a history of blood clots, certain cancers such as breast or other estrogen-dependent cancers, liver disease, uncontrolled high blood pressure, or migraine with aura.

Tri-Sprintec does not protect against HIV or other sexually transmitted infections. Its effectiveness can be reduced by certain drug interactions, such as some anticonvulsants, rifampin, and St. John's wort. Watch for warning signs of a clot and seek care promptly if they occur. This information is a summary, not medical advice; talk with your doctor or pharmacist about your full history and any other medicines you take before starting or stopping this pill.

Sources & accuracy

This Tri-Sprintec information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Tri-Sprintec on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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