Asenapine Maleate
Asenapine Maleate 10MG
What is Asenapine Maleate?
Asenapine Maleate is a medication used to help manage symptoms of schizophrenia and bipolar disorder. It works by affecting certain natural substances in the brain to improve mood and thinking.Side Effects
- Jerky muscle movement you cannot control (often in your face, tongue, or jaw), problems with balance or walking
- Numbness or tingling in your mouth or throat, sores or blisters in your mouth
- Lightheadedness, dizziness, drowsiness, or fainting
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, diabetes, high cholesterol, trouble swallowing, or a history of seizures. Tell your doctor if you have a blood vessel or heart problem, including low blood pressure, heart failure, heart rhythm problems, or a history of heart attack or stroke.
- This medicine may cause the following problems: Neuroleptic malignant syndrome (NMS), which can be life-threateningTardive dyskinesia (a movement disorder) that may not go away after you stop using this medicineHeart rhythm changes, such as QT prolongationIncreased risk for infections
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly. You may feel lightheaded if you get up suddenly from a lying or sitting position.
- You might get overheated while you are taking this medicine. Drink more water during hot weather, and while you exercise.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Prescription savings · · · ·
What is Asenapine Maleate ?
Asenapine Maleate is a medication used to help manage symptoms of schizophrenia and bipolar disorder. It works by affecting certain natural substances in the brain to improve mood and thinking.- Jerky muscle movement you cannot control (often in your face, tongue, or jaw), problems with balance or walking
- Numbness or tingling in your mouth or throat, sores or blisters in your mouth
- Lightheadedness, dizziness, drowsiness, or fainting
- Seizures, tremors, or twitching
- Sweating, confusion, muscle stiffness
- Mood or behavior changes, or thoughts of hurting yourself or others
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Fast, slow, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, and body aches
- Increased hunger or thirst, frequent urination, tiredness, blurred vision
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, diabetes, high cholesterol, trouble swallowing, or a history of seizures. Tell your doctor if you have a blood vessel or heart problem, including low blood pressure, heart failure, heart rhythm problems, or a history of heart attack or stroke.
- This medicine may cause the following problems: Neuroleptic malignant syndrome (NMS), which can be life-threateningTardive dyskinesia (a movement disorder) that may not go away after you stop using this medicineHeart rhythm changes, such as QT prolongationIncreased risk for infections
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly. You may feel lightheaded if you get up suddenly from a lying or sitting position.
- You might get overheated while you are taking this medicine. Drink more water during hot weather, and while you exercise.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Lightheadedness, dizziness, drowsiness, or fainting
- Mood or behavior changes, or thoughts of hurting yourself or others
- Numbness or tingling in your mouth or throat, sores or blisters in your mouth
- Seizures, tremors, or twitching
Asenapine Maleate Coupons & Prices
Asenapine Maleate 10MG
Looking for an asenapine maleate coupon? Asenapine maleate is the generic version of the sublingual antipsychotic Saphris, and its cash price can swing widely from one pharmacy to the next, so it pays to compare before you fill. Rx.com checks pricing across more than 60,000 U.S. pharmacies so you can find a nearby option and enter your ZIP above to see today's price.
What is asenapine maleate and how does it work?
Asenapine maleate is an atypical (second-generation) antipsychotic sold under the brand name Saphris and available as a generic. It's FDA-approved for schizophrenia in adults, for acute treatment of manic or mixed episodes of bipolar I disorder as monotherapy in adults and in pediatric patients 10 years and older, for maintenance monotherapy in bipolar I disorder in adults, and as an add-on treatment with lithium or valproate for bipolar I disorder in adults. It is sometimes prescribed off-label for other mood or behavioral concerns, but these FDA-approved uses are what the label covers.
Asenapine maleate (this generic version of Saphris) comes only as a sublingual tablet, meaning it's placed under the tongue and left to dissolve on its own rather than being chewed or swallowed. Food and drinks should be avoided for about 10 minutes after each dose so the medication can absorb properly.
Comparing prices without insurance
A generic version of Saphris is available, which typically opens up more pharmacy options and pricing competition than a brand-only drug. Even so, cash prices for generic asenapine maleate can vary a great deal by pharmacy, by dosage strength, and by location. Because there's no single "standard" cash price, comparing pharmacies before you fill is the best way to find a lower price near you.
Rx.com compares pricing across more than 60,000 U.S. pharmacies so you can see how nearby options stack up. Enter your ZIP code above to check today's price at pharmacies near you.
Asenapine maleate vs. other antipsychotics
Asenapine maleate is the generic form of the brand Saphris and belongs to the same broad class of atypical antipsychotics as other options your provider may consider, including olanzapine, risperidone, quetiapine, lurasidone, and aripiprazole. These medications differ in dosing form, side-effect profile, and specific FDA-approved uses, so switching between them is a decision for you and your prescriber, not a like-for-like swap.
Saphris also offers a manufacturer copay savings program for eligible patients; check the manufacturer's website for current program details, as terms, eligibility, and savings amounts vary and are set by the manufacturer.
Safety information
Asenapine carries a boxed warning: elderly patients with dementia-related psychosis treated with antipsychotic drugs like asenapine have an increased risk of death, and asenapine is not approved for this use. Other risks noted in the label include neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes such as high blood sugar, diabetes, weight gain and cholesterol changes, low blood pressure on standing (with possible fainting), low white blood cell counts, seizures, impaired judgment or motor skills, trouble regulating body temperature, difficulty swallowing, and rare but serious allergic reactions.
Because it's a sublingual tablet, it must dissolve completely under the tongue and not be chewed or swallowed, and you should avoid eating or drinking for about 10 minutes afterward. This is general information, not medical advice — talk with your provider or pharmacist about whether asenapine is right for you and how to take it safely.
This Asenapine Maleate information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Asenapine Maleate on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.