Fentanyl
fentaNYL 5 Patch 72 Hour
What is Fentanyl?
Fentanyl is a generic drug used to prevent pain from occurring in patients after surgery. The average Fentanyl price is about $141 for 2 boxes of 5 patches (25mcg/hr). You can use our Rx.com savings offer to get an average Fentanyl discount of up to 80% at participating pharmacies near you.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin
Warnings
- Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, breathing or lung problems (such as COPD, apnea, sleep apnea), adrenal problems, low blood pressure, pancreas or gallbladder problems, slow heartbeat, stomach or bowel problems, or a history of head injury, brain tumor, depression, seizures, or alcohol or drug abuse.
- Do not breastfeed while using this medicine.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome, when used with certain medicines
- Do not let the patch get too hot. Avoid direct sunlight, and do not use a heating pad, electric blanket, heated water bed, sauna, sun lamp, or hot tub. Call your doctor if you have a fever higher than 104 degrees F (40 degrees C).
- Be careful about letting other people come in contact with your patch. If any medicine gets on another person, wash it off right away with water and call your doctor.
Prescription savings · · · ·
What is Fentanyl ?
Fentanyl is a generic drug used to prevent pain from occurring in patients after surgery. The average Fentanyl price is about $141 for 2 boxes of 5 patches (25mcg/hr). You can use our Rx.com savings offer to get an average Fentanyl discount of up to 80% at participating pharmacies near you.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
- Severe constipation, stomach pain, or vomiting
- Trouble breathing or slow breathing
- Severe confusion, lightheadedness, dizziness, or fainting
- Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, breathing or lung problems (such as COPD, apnea, sleep apnea), adrenal problems, low blood pressure, pancreas or gallbladder problems, slow heartbeat, stomach or bowel problems, or a history of head injury, brain tumor, depression, seizures, or alcohol or drug abuse.
- Do not breastfeed while using this medicine.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Serotonin syndrome, when used with certain medicines
- Do not let the patch get too hot. Avoid direct sunlight, and do not use a heating pad, electric blanket, heated water bed, sauna, sun lamp, or hot tub. Call your doctor if you have a fever higher than 104 degrees F (40 degrees C).
- Be careful about letting other people come in contact with your patch. If any medicine gets on another person, wash it off right away with water and call your doctor.
- This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Fentanyl Coupons & Prices
fentaNYL 5 Patch 72 Hour
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a fentanyl coupon? Fentanyl is a prescription opioid pain medicine available as a low-cost generic, but the cash price can vary widely from one pharmacy to the next. Rx.com compares live prices across more than 60,000 U.S. pharmacies so you can find the lowest price near you. Enter your ZIP above to see today's price and print a free discount coupon that works whether or not you have insurance.
What is fentanyl and how does it work?
Fentanyl is a synthetic opioid analgesic (a narcotic pain reliever) that works on opioid receptors in the brain and nervous system to reduce the sensation of severe pain. It is FDA-approved only for the management of severe pain and comes in several very different forms. The transdermal patch (Duragesic) is prescribed for around-the-clock chronic pain that requires daily, long-term opioid treatment in patients who are already opioid-tolerant.
Rapid-onset forms, including the oral lozenge (Actiq), buccal tablet (Fentora), sublingual tablet (Abstral), sublingual spray (Subsys), and nasal spray (Lazanda), are approved only for breakthrough cancer pain in opioid-tolerant adults and are tightly controlled under the TIRF REMS program. Injectable fentanyl (Sublimaze) is used in medical settings for anesthesia and procedural sedation. Because it is a Schedule II controlled substance, fentanyl always requires a prescription and close supervision from your prescriber.
Fentanyl cost and savings without insurance
Fentanyl is available as a generic, which usually keeps the cost far lower than brand-name versions. Even so, the cash price is not the same everywhere. Pharmacies set their own prices, and the amount you pay without insurance can differ significantly across town, so comparing pharmacies genuinely matters. That is where a discount coupon can help, whether you are uninsured or your plan does not cover a particular form or strength.
Rx.com checks prices at more than 60,000 pharmacies and shows you today's price for your specific form and strength. Enter your ZIP above to see the current price near you and print or show your free coupon at the counter. There is no manufacturer savings card for generic fentanyl, and no membership is required to use an Rx.com discount.
Fentanyl vs. other opioid pain medicines
Fentanyl is one of several strong opioids used for severe pain, and the right choice depends entirely on your condition and your prescriber's judgment. The brand-name patch equivalent is Duragesic, and the oral lozenge brand is Actiq. Other opioids your doctor may discuss include morphine, oxycodone, hydromorphone, and methadone.
For opioid dependence or as part of a treatment plan, providers may also use buprenorphine. And naloxone is the emergency medicine that reverses an opioid overdose. If your prescriber writes you any of these, you can compare cash prices for each on Rx.com to see which is most affordable at your pharmacy. This information is for comparison only and is not medical advice.
Important safety information
Fentanyl carries boxed warnings, the FDA's strongest safety alerts. It has a high risk of addiction, abuse, and misuse that can lead to overdose and death, and it can cause life-threatening slowed or stopped breathing, especially when treatment starts, when the dose increases, or in anyone who is not already opioid-tolerant. Accidental exposure, particularly a child touching or swallowing a patch, can be fatal, so store and dispose of it carefully. Never combine fentanyl with alcohol, benzodiazepines, or other medicines that slow the nervous system, and tell your doctor about all medications you take, because certain drugs (CYP3A4 inhibitors) can raise fentanyl to dangerous levels.
Heat matters with the patch: a fever, heating pad, electric blanket, or hot bath can speed up how much medicine is released and cause an overdose. Used during pregnancy, fentanyl can cause withdrawal in a newborn. Naloxone can reverse an overdose. This is a summary, not a complete list of warnings, and it is not medical advice. Follow your prescriber's directions exactly and ask your doctor or pharmacist any questions. Note that illicitly made fentanyl, a leading cause of U.S. overdose deaths, is a separate issue from medicine prescribed and monitored by your doctor.
This Fentanyl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Fentanyl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.