Morphine Sulfate (Concentrate) Coupons & Prices

Morphine sulfate oral solution, concentrate (20 mg/mL) is a Schedule II opioid pain medication now sold only as a generic — the brand Roxanol has been discontinued in the United States. Because pharmacies set their own cash prices and they can vary widely for this drug, comparing before you fill matters. Rx.com compares prices across more than 60,000 U.S. pharmacies for a morphine sulfate concentrate coupon, so enter your ZIP code above to see today's price near you.

What Is Morphine Sulfate Oral Solution Concentrate?

Morphine sulfate oral solution, concentrate is a highly concentrated liquid form of morphine (20 mg per mL) that binds primarily to mu-opioid receptors in the brain and spinal cord to reduce the perception of pain. It's an opioid agonist and a Schedule II controlled substance, indicated for the management of acute and chronic pain in opioid-tolerant patients that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It isn't used in patients who haven't previously taken opioids (opioid-naive patients) — the FDA label specifically limits this 20 mg/mL strength to patients who have already been titrated to a stable analgesic regimen on a lower-strength morphine sulfate solution before switching to the concentrate.

This concentrated formulation is commonly associated with hospice, palliative care, and cancer-pain settings, where patients need a small liquid volume that still delivers a large opioid dose — though the FDA label doesn't restrict its use to those settings. It was formerly marketed under the brand name Roxanol (also sold as Roxanol-T and Roxanol 100), but that brand has been discontinued in the U.S.; today the medication is available only as the generic morphine sulfate oral solution, concentrate.

Morphine Sulfate Concentrate Cost and Coupons

A generic version of morphine sulfate oral solution, concentrate is available, and since there's no brand product left on the market, every prescription filled today is already the generic. That doesn't mean the price is the same everywhere — cash prices for controlled substances like this one can vary significantly from one pharmacy to the next, and not every pharmacy stocks this concentrated form. That's exactly why comparing pharmacies is worth doing before you fill.

Rx.com checks pricing across more than 60,000 pharmacies nationwide so you can see which one offers the best price near you. Enter your ZIP code above to see today's price and pharmacy options for morphine sulfate concentrate.

Morphine Sulfate Concentrate vs. Other Opioid Pain Medications

Morphine is available in several other forms besides the concentrated solution. Immediate-release morphine sulfate is also available as a standard-strength oral liquid, tablet, or injectable, while extended-release morphine sulfate is dosed less frequently for around-the-clock pain control. Your provider chooses the concentration and release type based on your opioid tolerance, how much pain control you need, and how easily you can swallow or measure liquid medication.

Other opioid analgesics used for moderate-to-severe pain include oxycodone, hydromorphone, and fentanyl. These drugs differ in potency, how long they last, and available forms, so switching between them isn't a simple substitution — dosing has to be calculated by a provider familiar with opioid conversion.

Safety Information

Morphine sulfate oral solution, concentrate carries boxed warnings on its FDA label. Because the medication is so concentrated, mixing up mg and mL, or confusing this concentration with a different one, can cause a fatal overdose — always use only the calibrated measuring device that comes with the prescription, never a household spoon. The medication also carries boxed warnings for the risk of addiction, abuse, and misuse; for serious, life-threatening, or fatal breathing problems (respiratory depression), especially when starting treatment or after a dose increase; for the danger that even a single accidental dose can be fatal to a child; for neonatal opioid withdrawal syndrome with prolonged use in pregnancy; and for the added danger of combining this medication with benzodiazepines or other drugs that depress the central nervous system, which can cause extreme sedation, breathing problems, coma, or death.

This concentrated form is only for patients who are already opioid-tolerant; it should not be given to patients who haven't taken opioids regularly, and it's contraindicated in significant respiratory depression, acute or severe asthma, known or suspected bowel obstruction, and in patients who have taken an MAOI within the past two weeks. This is general information, not medical advice — follow your provider's and pharmacist's instructions exactly, and ask them any questions about your specific dose.