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Olanzapine

Olanzapine

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What is Olanzapine?

Olanzapine is a prescription atypical antipsychotic used to treat schizophrenia and bipolar disorder (including acute manic episodes and maintenance therapy). It is also used in combination with fluoxetine for treatment-resistant depression and bipolar depression (as Symbyax). Olanzapine is known for its broad symptom coverage — addressing both positive symptoms (hallucinations, delusions) and negative symptoms (flat affect, social withdrawal) of schizophrenia. Olanzapine works by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain, helping to correct the neurotransmitter imbalances associated with psychosis and mania. Available as oral tablets, orally disintegrating tablets, and a short-acting injectable formulation. Typical doses range from 5–20 mg per day. A licensed psychiatric provider on Rx.com can evaluate mental health symptoms and prescribe olanzapine if it is appropriate.

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What is Olanzapine ?

Olanzapine is a prescription atypical antipsychotic used to treat schizophrenia and bipolar disorder (including acute manic episodes and maintenance therapy). It is also used in combination with fluoxetine for treatment-resistant depression and bipolar depression (as Symbyax). Olanzapine is known for its broad symptom coverage — addressing both positive symptoms (hallucinations, delusions) and negative symptoms (flat affect, social withdrawal) of schizophrenia. Olanzapine works by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain, helping to correct the neurotransmitter imbalances associated with psychosis and mania. Available as oral tablets, orally disintegrating tablets, and a short-acting injectable formulation. Typical doses range from 5–20 mg per day. A licensed psychiatric provider on Rx.com can evaluate mental health symptoms and prescribe olanzapine if it is appropriate.
  • Trouble breathing or swallowing
  • Unusual bleeding, bruising, or weakness
  • Unusual behavior, thoughts of hurting yourself or others
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Eye pain, trouble seeing
  • Feeling very thirsty or hungry, change in how much or how often you urinate
  • Fever, chills, cough, sore throat, body aches
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw)
  • Lightheadedness, dizziness, fainting
  • Seizures or tremors
  • Sweating, confusion, uneven heartbeat, muscle stiffness
  • Swollen breasts, or liquid discharge from your nipples (men or women)
  • Swollen, painful, or tender lymph glands in neck, armpit, or groin
  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, diabetes, glaucoma, prostate problems, problems with passing urine, breast cancer, seizures, or severe constipation. Tell your doctor if you have any kind of heart or circulation problems, including low blood pressure, heart failure, heart rhythm problems, or a history of a heart attack or stroke. Tell your doctor if you have a condition called phenylketonuria.
  • Do not breastfeed while you are using this medicine.
  • This medicine may cause the following problems:Changes in behavior or mood, including thoughts of suicideNeuroleptic malignant syndrome (a nerve and muscle problem)Drug reaction with eosinophilia and systemic symptoms (DRESS)High blood sugar, cholesterol, or triglyceride levelsTardive dyskinesia (a muscle problem that may become permanent)
  • This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movement, which may lead to falls, fractures or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • This medicine may make it more difficult for your body to cool down. Be careful to not become overheated during exercise or hot weather, because you could have heat stroke.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Severe sleepiness, slurred speech, or trouble with breathing.
  • Shakiness, problems with balance or walking.
  • Swelling in your hands, ankles, or feet.
  • Swollen breasts, or liquid discharge from your nipples (men or women).
  • Trouble with swallowing.
How much does Olanzapine cost without insurance?
The price of Olanzapine without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Olanzapine?
Common side effects of Olanzapine may include: Trouble breathing or swallowing, Unusual bleeding, bruising, or weakness, Unusual behavior, thoughts of hurting yourself or others, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Eye pain, trouble seeing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Olanzapine?
Generic versions may be available for Olanzapine. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Olanzapine on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Olanzapine?
The cheapest pharmacy for Olanzapine depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Olanzapine near you.

Olanzapine Coupons & Prices

Olanzapine

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What Is Olanzapine?

Olanzapine (brand name Zyprexa) is a second-generation (atypical) antipsychotic used for schizophrenia, bipolar disorder, and as part of a combination treatment for treatment-resistant depression. It is one of the most extensively studied antipsychotics and is considered highly effective for both positive and negative symptoms of psychosis.

FDA-Approved Indications

  • Schizophrenia — acute and maintenance treatment in adults and adolescents (ages 13+)
  • Bipolar I disorder — acute manic or mixed episodes; maintenance treatment
  • Bipolar depression — in combination with fluoxetine (as Symbyax)
  • Treatment-resistant depression — adjunct to fluoxetine in adults

How Does Olanzapine Work?

Olanzapine blocks multiple neurotransmitter receptors, primarily:

  • Dopamine D2 receptors — reduces dopaminergic overactivity in mesolimbic pathways (controls psychosis)
  • Serotonin 5-HT2A receptors — improves negative symptoms and mood
  • Also blocks histamine H1 and muscarinic M1 receptors (contributing to sedation and metabolic effects)

Dosage Overview

  • Schizophrenia (adults): 5–10 mg/day initially; target 10 mg/day; range 10–20 mg/day
  • Bipolar mania (adults): 10–15 mg/day; range 5–20 mg/day
  • Adolescents: Lower starting doses (2.5–5 mg/day)

Metabolic Monitoring

Olanzapine is associated with significant weight gain, elevated blood sugar, and dyslipidemia. Regular monitoring of weight, blood glucose, and lipids is essential during treatment.

Save on Olanzapine

Generic olanzapine is affordable. With an Rx.com coupon, a 30-day supply can cost as little as $15–$35.

Mental Health Support — Start Online

See a licensed psychiatric provider on Rx.com for a confidential online evaluation of schizophrenia or bipolar disorder.

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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