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Buprenorphine Hcl Tablet Sublingual — prescription drug image

Buprenorphine Hcl

Buprenorphine HCl 8MG

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What is Buprenorphine Hcl?

If you are diagnosed with opioid dependence, your doctor might prescribe buprenorphine/naloxone. Other treatments, such as counseling, are also frequently used to treat opioid dependence. Since buprenorphine/naloxone may be habit forming, it should only be taken under the guidance of an experienced physician.

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What is Buprenorphine Hcl ?

If you are diagnosed with opioid dependence, your doctor might prescribe buprenorphine/naloxone. Other treatments, such as counseling, are also frequently used to treat opioid dependence. Since buprenorphine/naloxone may be habit forming, it should only be taken under the guidance of an experienced physician.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
  • Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Extreme dizziness or weakness, shallow breathing, sweating, seizures, cold or clammy skin
  • Fast, pounding, or uneven heartbeat
  • Severe constipation
  • Toothache
  • Severe confusion, lightheadedness, dizziness, or fainting
  • Worsening of pain, increased sensitivity to pain
  • Trouble breathing or slow breathing
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, an adrenal gland problem, an enlarged prostate, gallbladder problems, lung or breathing problems (including COPD, sleep apnea), tooth problems (including history of cavities), mouth sores or ulcers, pancreas problems, trouble urinating, an underactive thyroid, or mental health problems (including depression). Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have ever had a head injury, brain tumor, seizures, stroke, or alcohol or drug abuse.
  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem which can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Worsening of painAdrenal gland problemsQT prolongation (heart rhythm problem)Tooth problems (including tooth fracture, tooth loss)Low blood pressureLiver problemsSerotonin syndrome, when used with certain medicines
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is buprenorphine HCl used for?
Buprenorphine HCl sublingual tablets are FDA-approved to treat opioid dependence, also called opioid use disorder, as part of a complete treatment plan that includes counseling and psychosocial support. The label states that this single-ingredient tablet does not contain naloxone and is preferred for use only during induction, the first days of treatment. After induction, the label says buprenorphine and naloxone sublingual film or tablets are preferred for unsupervised use because they contain naloxone. Your prescriber decides which product fits your treatment plan.
What is the difference between buprenorphine and Suboxone?
Buprenorphine HCl sublingual tablets contain buprenorphine alone. Suboxone contains buprenorphine plus naloxone. The naloxone is included to discourage misuse by injection. Per the labeling, the plain buprenorphine tablet is preferred for use only during induction, while a buprenorphine and naloxone product is preferred afterward for unsupervised use. Your prescriber decides which one fits your treatment plan.
Is buprenorphine a controlled substance?
Yes. Buprenorphine is a Schedule III (C-III) controlled substance in the United States. It carries a risk of abuse, misuse, and diversion, so it requires a valid prescription and pharmacies handle it under controlled-substance rules. That can affect stock and where you are able to fill it, so it is worth calling ahead.
Can you take buprenorphine for pain?
No. Per the FDA label, buprenorphine HCl sublingual tablets are not appropriate as an analgesic. Pain indications belong to different buprenorphine products, such as Belbuca, Butrans, and Buprenex. Deaths have been reported in people who had not been taking opioids and received a 2 mg sublingual dose. Do not use this product for pain, and talk to your provider about pain treatment options.
How do I use an Rx.com coupon for buprenorphine HCl?
Enter your ZIP code above to compare cash prices at pharmacies near you across more than 60,000 locations, then show the free coupon with your prescription at the counter. It is a cash discount, not insurance, and it cannot be combined with insurance on the same fill, so ask the pharmacist which price is lower for you. Prices for the same strength and quantity vary widely by pharmacy, so comparing before you fill is worthwhile.
How much does Buprenorphine Hcl cost without insurance?
The price of Buprenorphine Hcl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 92% off retail prices with a free Rx.com coupon.
What are the common side effects of Buprenorphine Hcl?
Common side effects of Buprenorphine Hcl may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there, Changes in skin color, dark freckles, cold feeling, tiredness, weight loss, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, Extreme dizziness or weakness, shallow breathing, sweating, seizures, cold or clammy skin. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Buprenorphine Hcl?
Generic versions may be available for Buprenorphine Hcl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Buprenorphine Hcl on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Buprenorphine Hcl?
The cheapest pharmacy for Buprenorphine Hcl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Buprenorphine Hcl near you.

Buprenorphine Hcl Coupons & Prices

Buprenorphine HCl 8MG

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Buprenorphine Hcl Tablet Sublingual — prescription drug image
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Buprenorphine Hcl 8mg (10)
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Use a free Rx.com buprenorphine HCl coupon to compare cash prices on generic buprenorphine hydrochloride sublingual tablets, the single-ingredient medication FDA-approved to treat opioid dependence (opioid use disorder). The brand Subutex is no longer marketed in the US, but FDA-approved generic sublingual tablets remain available. Cash prices for the same tablet and quantity can vary widely from one pharmacy to the next, which is why comparing matters. Rx.com checks prices at more than 60,000 pharmacies nationwide. Enter your ZIP above to see today's price near you.

What is buprenorphine HCl and how does it work?

Buprenorphine hydrochloride is an opioid partial agonist. It partially activates the mu-opioid receptor and blocks the kappa-opioid receptor. Because it only partially activates the receptor, it can ease opioid cravings and withdrawal symptoms without producing the full effect of drugs like heroin or oxycodone. It is one of the medications for opioid use disorder, often shortened to MOUD.

This page covers the single-ingredient buprenorphine HCl sublingual tablet, which is placed under the tongue and allowed to dissolve. Per its FDA label it is indicated for the treatment of opioid dependence and should be used as part of a complete treatment plan that includes counseling and psychosocial support. The label notes that this tablet does not contain naloxone and is preferred for use only during induction, the first days of treatment. Following induction, the label states that buprenorphine and naloxone sublingual film or tablets are preferred for unsupervised use because of the naloxone component. Buprenorphine HCl sublingual tablets are not appropriate as a pain reliever. Your prescriber decides which product and schedule fit your situation.

Buprenorphine HCl cost and coupons without insurance

Buprenorphine HCl sublingual tablets are available as an FDA-approved generic, and there is no brand manufacturer savings card for this product since Subutex is no longer marketed in the US. If you are paying cash, the price you are quoted depends heavily on which pharmacy you walk into, the strength, and the quantity your prescription calls for. Two pharmacies a few blocks apart can quote very different cash prices for the identical tablet.

An Rx.com coupon is free and works as a cash-price discount at the pharmacy counter. It is not insurance, and it cannot be combined with insurance on the same fill, so it is worth asking the pharmacist which is lower for you. Enter your ZIP above to see today's price at pharmacies near you, then bring the coupon with your prescription. Because this is a controlled substance, the pharmacy has to have it in stock and your prescription has to be valid for that pharmacy, so calling ahead can save a trip.

Buprenorphine HCl vs. Suboxone and other options

Several products contain buprenorphine, and they are not interchangeable. Only the plain sublingual tablet is what this coupon covers.

  • Suboxone and buprenorphine/naloxone, plus Zubsolv, combine buprenorphine with naloxone and are commonly used for maintenance treatment.
  • Sublocade is an extended-release buprenorphine injection given by a healthcare provider.
  • Methadone and naltrexone are different medications used in opioid use disorder treatment.
  • Naloxone is the rescue medication used to reverse an opioid overdose.
  • Belbuca and Butrans contain buprenorphine but are approved for pain, not for opioid dependence.

Switching between these is a decision for your prescriber, not a substitution to make at the pharmacy counter. Ask which product your treatment plan calls for before you compare prices.

Safety information you should know

This is general information and not medical advice. Talk with your prescriber or pharmacist about your own situation. Buprenorphine HCl is a Schedule C-III controlled substance and carries a risk of abuse, misuse, and diversion. It can cause life-threatening respiratory depression, and that risk is greatly increased when it is combined with benzodiazepines, alcohol, or other central nervous system depressants, so do not add those on your own. Deaths have been reported in people who had not been taking opioids and received a 2 mg sublingual dose. It is not labeled for pain. Never crush or inject the sublingual tablet; injecting it can cause severe reactions and precipitated withdrawal. Starting it too soon after a full opioid agonist can also precipitate withdrawal. Naloxone should be available in case of overdose, and higher or repeated naloxone doses may be needed.

Use during pregnancy may cause neonatal opioid withdrawal syndrome, which can be life threatening if it is not recognized, so tell your provider if you are or may become pregnant. Dental problems including cavities, infection, and tooth fracture or loss have been reported with sublingual and buccal buprenorphine; rinse your mouth with water after the tablet dissolves and wait before brushing. Other reported risks include liver injury or hepatitis, adrenal insufficiency, orthostatic hypotension, and QT effects at higher doses. Common side effects include numbness or soreness in the mouth, mouth redness, headache, nausea, vomiting, sweating, constipation, trouble sleeping, pain, and swelling in the hands or feet. Do not stop taking it abruptly without medical guidance.

Sources & accuracy

This Buprenorphine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Buprenorphine Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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