Buprenorphine Hcl
Buprenorphine HCl 8MG
What is Buprenorphine Hcl?
If you are diagnosed with opioid dependence, your doctor might prescribe buprenorphine/naloxone. Other treatments, such as counseling, are also frequently used to treat opioid dependence. Since buprenorphine/naloxone may be habit forming, it should only be taken under the guidance of an experienced physician.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, an adrenal gland problem, an enlarged prostate, gallbladder problems, lung or breathing problems (including COPD, sleep apnea), tooth problems (including history of cavities), mouth sores or ulcers, pancreas problems, trouble urinating, an underactive thyroid, or mental health problems (including depression). Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have ever had a head injury, brain tumor, seizures, stroke, or alcohol or drug abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem which can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Worsening of painAdrenal gland problemsQT prolongation (heart rhythm problem)Tooth problems (including tooth fracture, tooth loss)Low blood pressureLiver problemsSerotonin syndrome, when used with certain medicines
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- Tell any doctor or dentist who treats you that you are using this medicine.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Prescription savings · · · ·
What is Buprenorphine Hcl ?
If you are diagnosed with opioid dependence, your doctor might prescribe buprenorphine/naloxone. Other treatments, such as counseling, are also frequently used to treat opioid dependence. Since buprenorphine/naloxone may be habit forming, it should only be taken under the guidance of an experienced physician.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Extreme dizziness or weakness, shallow breathing, sweating, seizures, cold or clammy skin
- Fast, pounding, or uneven heartbeat
- Severe constipation
- Toothache
- Severe confusion, lightheadedness, dizziness, or fainting
- Worsening of pain, increased sensitivity to pain
- Trouble breathing or slow breathing
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, an adrenal gland problem, an enlarged prostate, gallbladder problems, lung or breathing problems (including COPD, sleep apnea), tooth problems (including history of cavities), mouth sores or ulcers, pancreas problems, trouble urinating, an underactive thyroid, or mental health problems (including depression). Tell your doctor if you have heart disease, congestive heart failure, a slow heartbeat, or a history of heart rhythm problems (including long QT syndrome). Tell your doctor if you have ever had a head injury, brain tumor, seizures, stroke, or alcohol or drug abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem which can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Worsening of painAdrenal gland problemsQT prolongation (heart rhythm problem)Tooth problems (including tooth fracture, tooth loss)Low blood pressureLiver problemsSerotonin syndrome, when used with certain medicines
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- Tell any doctor or dentist who treats you that you are using this medicine.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Buprenorphine Hcl Coupons & Prices
Buprenorphine HCl 8MG
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Use a free Rx.com buprenorphine HCl coupon to compare cash prices on generic buprenorphine hydrochloride sublingual tablets, the single-ingredient medication FDA-approved to treat opioid dependence (opioid use disorder). The brand Subutex is no longer marketed in the US, but FDA-approved generic sublingual tablets remain available. Cash prices for the same tablet and quantity can vary widely from one pharmacy to the next, which is why comparing matters. Rx.com checks prices at more than 60,000 pharmacies nationwide. Enter your ZIP above to see today's price near you.
What is buprenorphine HCl and how does it work?
Buprenorphine hydrochloride is an opioid partial agonist. It partially activates the mu-opioid receptor and blocks the kappa-opioid receptor. Because it only partially activates the receptor, it can ease opioid cravings and withdrawal symptoms without producing the full effect of drugs like heroin or oxycodone. It is one of the medications for opioid use disorder, often shortened to MOUD.
This page covers the single-ingredient buprenorphine HCl sublingual tablet, which is placed under the tongue and allowed to dissolve. Per its FDA label it is indicated for the treatment of opioid dependence and should be used as part of a complete treatment plan that includes counseling and psychosocial support. The label notes that this tablet does not contain naloxone and is preferred for use only during induction, the first days of treatment. Following induction, the label states that buprenorphine and naloxone sublingual film or tablets are preferred for unsupervised use because of the naloxone component. Buprenorphine HCl sublingual tablets are not appropriate as a pain reliever. Your prescriber decides which product and schedule fit your situation.
Buprenorphine HCl cost and coupons without insurance
Buprenorphine HCl sublingual tablets are available as an FDA-approved generic, and there is no brand manufacturer savings card for this product since Subutex is no longer marketed in the US. If you are paying cash, the price you are quoted depends heavily on which pharmacy you walk into, the strength, and the quantity your prescription calls for. Two pharmacies a few blocks apart can quote very different cash prices for the identical tablet.
An Rx.com coupon is free and works as a cash-price discount at the pharmacy counter. It is not insurance, and it cannot be combined with insurance on the same fill, so it is worth asking the pharmacist which is lower for you. Enter your ZIP above to see today's price at pharmacies near you, then bring the coupon with your prescription. Because this is a controlled substance, the pharmacy has to have it in stock and your prescription has to be valid for that pharmacy, so calling ahead can save a trip.
Buprenorphine HCl vs. Suboxone and other options
Several products contain buprenorphine, and they are not interchangeable. Only the plain sublingual tablet is what this coupon covers.
- Suboxone and buprenorphine/naloxone, plus Zubsolv, combine buprenorphine with naloxone and are commonly used for maintenance treatment.
- Sublocade is an extended-release buprenorphine injection given by a healthcare provider.
- Methadone and naltrexone are different medications used in opioid use disorder treatment.
- Naloxone is the rescue medication used to reverse an opioid overdose.
- Belbuca and Butrans contain buprenorphine but are approved for pain, not for opioid dependence.
Switching between these is a decision for your prescriber, not a substitution to make at the pharmacy counter. Ask which product your treatment plan calls for before you compare prices.
Safety information you should know
This is general information and not medical advice. Talk with your prescriber or pharmacist about your own situation. Buprenorphine HCl is a Schedule C-III controlled substance and carries a risk of abuse, misuse, and diversion. It can cause life-threatening respiratory depression, and that risk is greatly increased when it is combined with benzodiazepines, alcohol, or other central nervous system depressants, so do not add those on your own. Deaths have been reported in people who had not been taking opioids and received a 2 mg sublingual dose. It is not labeled for pain. Never crush or inject the sublingual tablet; injecting it can cause severe reactions and precipitated withdrawal. Starting it too soon after a full opioid agonist can also precipitate withdrawal. Naloxone should be available in case of overdose, and higher or repeated naloxone doses may be needed.
Use during pregnancy may cause neonatal opioid withdrawal syndrome, which can be life threatening if it is not recognized, so tell your provider if you are or may become pregnant. Dental problems including cavities, infection, and tooth fracture or loss have been reported with sublingual and buccal buprenorphine; rinse your mouth with water after the tablet dissolves and wait before brushing. Other reported risks include liver injury or hepatitis, adrenal insufficiency, orthostatic hypotension, and QT effects at higher doses. Common side effects include numbness or soreness in the mouth, mouth redness, headache, nausea, vomiting, sweating, constipation, trouble sleeping, pain, and swelling in the hands or feet. Do not stop taking it abruptly without medical guidance.
This Buprenorphine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Buprenorphine Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.