Contrave Coupons & Prices

If you're looking for a Contrave coupon, Rx.com shows you today's price on naltrexone HCl / bupropion HCl extended-release tablets at pharmacies near you — whether you're comparing it against the manufacturer's savings card, paying cash because you're uninsured, or filling on Medicare. Contrave is FDA-approved as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity (BMI ≥30) or who are overweight (BMI ≥27) with at least one weight-related health condition. Enter your ZIP code above to see today's price at pharmacies near you.

What Is Contrave and How Does It Work?

Contrave combines two existing medications, naltrexone hydrochloride (an opioid antagonist) and bupropion hydrochloride (an aminoketone antidepressant and norepinephrine-dopamine reuptake inhibitor), in a single extended-release tablet. Together they act on the hypothalamic melanocortin pathway and the brain's mesolimbic reward circuit, the systems involved in appetite and food-related reward. Contrave is FDA-approved as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity, or who are overweight with at least one weight-related condition such as hypertension, type 2 diabetes, or dyslipidemia.

Contrave is not approved to treat depression or any other psychiatric disorder, and it is not approved for use in anyone under 18. There is currently no generic version of Contrave available in the U.S.; outside the U.S., the same combination is marketed under the brand name Mysimba.

Contrave Cost: Manufacturer Savings Card vs. Rx.com Coupon

Because there is no generic naltrexone/bupropion ER combination product, Contrave is only available as the brand. The manufacturer offers its own Contrave Savings Card program directly through its official website — these manufacturer cards are generally limited to patients with commercial or private insurance, and eligibility, terms, and conditions vary and can change, so it's worth checking the manufacturer's site for current details.

Rx.com's cash coupon is a different tool: it works regardless of insurance status, so it's useful if you're uninsured, on Medicare, between plans, or if the manufacturer's card is declined at the register. Pharmacy cash prices for Contrave vary by location and pharmacy, so enter your ZIP code above to see today's price near you.

Contrave vs. Wegovy, Zepbound, Qsymia, and Other Weight-Management Options

Contrave is an oral tablet, taken by mouth, that works through appetite- and reward-related pathways in the brain rather than through the GLP-1 hormone system. Wegovy and Zepbound are injectable, GLP-1/GIP receptor-based medications also FDA-approved for chronic weight management; Qsymia (phentermine-topiramate) is another oral combination option. Ozempic is a semaglutide product FDA-approved for type 2 diabetes that is often discussed in weight-management conversations. These medications differ in mechanism, route of administration, and how they're prescribed, so talk with your provider about which fits your health history.

Contrave's two components, naltrexone and bupropion, are also each available on their own for their individually approved uses; Contrave combines both into one extended-release tablet specifically for chronic weight management, so the individual drugs are not interchangeable with the combination product.

Contrave Safety Information

Contrave carries a boxed warning, shared with other bupropion-containing products, for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults up to age 24, particularly during the first months of treatment. Contrave should not be used by people with seizure disorders or other conditions that lower the seizure threshold, uncontrolled hypertension, current or recent (within 14 days) use of an MAOI, chronic opioid or opiate use (including methadone or buprenorphine) or during acute opioid withdrawal, or a current or prior diagnosis of bulimia or anorexia nervosa. It should also not be started during abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs.

Other risks described in the label include seizures, increases in blood pressure and heart rate (which should be monitored, especially early in treatment), liver injury, angle-closure glaucoma, and activation of mania in people with bipolar disorder. Because naltrexone blocks the effects of opioid pain medications, Contrave can also raise the risk of accidental opioid overdose if opioids are needed later, such as in an emergency. This is general information, not medical advice — talk with your doctor or pharmacist about whether Contrave is right for you.