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Metformin Hcl Er (Mod) Tablet Extended Release 24 Hour — prescription drug image

Metformin Hcl Er (Mod)

metFORMIN HCl ER (MOD) 1000MG

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What is Metformin Hcl Er (Mod)?

Metformin HCl ER (mod) is an extended-release formulation of metformin hydrochloride, primarily used to manage type 2 diabetes mellitus. It works by improving insulin sensitivity and reducing hepatic glucose production, thereby helping control blood sugar levels. This modified-release version allows for once-daily dosing to maintain steady medication levels in the body, enhancing patient compliance and minimizing gastrointestinal side effects.

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What is Metformin Hcl Er (Mod) ?

Metformin HCl ER (mod) is an extended-release formulation of metformin hydrochloride, primarily used to manage type 2 diabetes mellitus. It works by improving insulin sensitivity and reducing hepatic glucose production, thereby helping control blood sugar levels. This modified-release version allows for once-daily dosing to maintain steady medication levels in the body, enhancing patient compliance and minimizing gastrointestinal side effects.
  • Confusion, fast heartbeat, increased hunger, shakiness
  • Trouble breathing, slow heartbeat, lightheadedness, dizziness
  • Stomach pain, nausea, vomiting, muscle pain or cramping
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever or chills
  • Unusual tiredness or weakness
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart failure, blood circulation problems, anemia, metabolic acidosis, an adrenal gland or pituitary gland disorder, vitamin B12 deficiency, or had a heart attack. Tell your doctor if you drink alcohol.
  • Too much of this medicine can cause a rare, but serious condition called lactic acidosis.
  • Part of the extended-release tablet may pass in your stool. This is normal.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery, an x-ray, CT scan, or other medical test.
  • This medicine may cause some premenopausal women who do not have regular monthly periods to ovulate. This can increase the chance of pregnancy. If you are a woman of childbearing potential, discuss birth control options with your doctor.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is metformin HCl ER used for?
Metformin HCl extended-release is used together with diet and exercise, and sometimes with other medicines or insulin, to control high blood sugar in adults and children with type 2 diabetes mellitus. It lowers the glucose your liver produces, reduces how much glucose your intestines absorb, and improves your body's response to insulin. It is not used for type 1 diabetes or diabetic ketoacidosis.
What is the difference between metformin ER and regular (immediate-release) metformin?
Both contain the same active ingredient. Immediate-release metformin dissolves quickly and is usually taken two or three times a day, while the extended-release (ER) form releases the medicine slowly over the day and is often taken just once daily. The ER form can be gentler on the stomach for some people. Your prescriber decides which form is right for you; do not switch on your own.
Why is there an empty tablet shell in my stool after taking metformin ER?
This is normal and expected with some extended-release tablets. The medicine is released slowly from a shell as the tablet moves through your digestive tract, and the empty, soft shell (sometimes called a ghost tablet) can pass out in your stool. It does not mean the medicine failed to work; the active drug has already been absorbed.
Can you crush or split metformin extended-release tablets?
No. Swallow the extended-release tablet whole. Do not crush, cut, or chew it, because that can release too much medicine at once and defeat the slow-release design. If you have trouble swallowing tablets, talk with your pharmacist or prescriber about other options.
What are the most serious side effects of metformin, and what is lactic acidosis?
The most serious risk is metformin-associated lactic acidosis, a rare but potentially fatal buildup of lactic acid in the blood. Symptoms can include feeling unwell, muscle aches, trouble breathing, unusual drowsiness, and stomach pain. The risk rises with kidney or liver problems, age over 65, iodinated contrast imaging, surgery, low-oxygen states, and heavy alcohol use. Metformin should not be used with significant kidney impairment or metabolic acidosis. Get medical help right away if you have these symptoms. This is not a complete list of side effects; ask your doctor or pharmacist.
How much does Metformin Hcl Er (Mod) cost without insurance?
The price of Metformin Hcl Er (Mod) without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save up to 99% off retail prices with a free Rx.com coupon.
What are the common side effects of Metformin Hcl Er (Mod)?
Common side effects of Metformin Hcl Er (Mod) may include: Confusion, fast heartbeat, increased hunger, shakiness, Trouble breathing, slow heartbeat, lightheadedness, dizziness, Stomach pain, nausea, vomiting, muscle pain or cramping, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fever or chills. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Metformin Hcl Er (Mod)?
Generic versions may be available for Metformin Hcl Er (Mod). Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Metformin Hcl Er (Mod) on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Metformin Hcl Er (Mod)?
The cheapest pharmacy for Metformin Hcl Er (Mod) depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Metformin Hcl Er (Mod) near you.

Metformin Hcl Er (Mod) Coupons & Prices

metFORMIN HCl ER (MOD) 1000MG

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Looking for a metformin HCl ER coupon? Metformin hydrochloride extended-release is a widely prescribed generic biguanide used with diet and exercise to control high blood sugar in adults and children with type 2 diabetes. Because it is available as a generic, it is already one of the lower-cost diabetes medicines, but the cash price can still vary a lot from one pharmacy to the next. Enter your ZIP above to see today's price and compare across more than 60,000 pharmacies with a free Rx.com discount coupon.

What is metformin HCl ER and how does it work?

Metformin hydrochloride extended-release (the generic form of brand-name products such as Glucophage XR, Fortamet, and Glumetza) is a biguanide antihyperglycemic taken by mouth. It is used together with diet and exercise, and sometimes with other medicines or insulin, to control high blood sugar in adults and children with type 2 diabetes mellitus. It works in three main ways: it lowers the amount of glucose your liver makes, reduces the amount of glucose your intestines absorb from food, and improves how well your body responds to its own insulin.

The extended-release (ER) form is designed to release the medicine slowly over the day, so it is usually taken once daily. Metformin is not used for type 1 diabetes or for diabetic ketoacidosis. It is your prescriber's decision whether metformin is right for you.

How much does generic metformin HCl ER cost without insurance?

Metformin is a generic, so it is already among the more affordable diabetes medicines, and you do not need insurance to use an Rx.com coupon. That said, the cash price is not the same everywhere; two pharmacies on the same street can charge noticeably different amounts for the exact same prescription. That is why comparing matters. Rx.com checks prices across more than 60,000 pharmacies so you can see who is lowest near you.

To see the current price, enter your ZIP above. Your live price will depend on your location, the pharmacy, the strength, and the quantity you are filling. Show the coupon to your pharmacist to use it. There is no manufacturer savings card for generic metformin ER.

Metformin ER alternatives and related medicines

Metformin comes in more than one form, and there are other diabetes medicines your prescriber may consider. Comparing options and prices can help you and your provider decide what fits best.

  • Metformin (immediate-release) — the standard-release version, usually taken two or three times a day.
  • Brand extended-release equivalents: Glucophage XR, Fortamet, and Glumetza.
  • Glipizide — a sulfonylurea that lowers blood sugar by a different mechanism.
  • Januvia (sitagliptin) — a DPP-4 inhibitor sometimes used alongside metformin.

Do not switch or stop any diabetes medicine on your own. Talk with your prescriber or pharmacist about which option is appropriate for you.

Safety, side effects, and the lactic acidosis warning

Metformin ER carries a boxed warning for metformin-associated lactic acidosis, a rare but serious and potentially life-threatening buildup of lactic acid in the blood. Warning signs can include feeling generally unwell, muscle aches, trouble breathing, unusual sleepiness, and stomach pain. The risk is higher with reduced kidney function, being over 65, imaging tests that use iodinated contrast dye, surgery, low-oxygen conditions, heavy alcohol use, and liver problems. If lactic acidosis is suspected, the medicine is stopped and urgent medical treatment is needed. Metformin should not be used if you have significant kidney impairment (eGFR below 30) or metabolic acidosis, and your prescriber will check your kidney function before you start and periodically after.

The most common side effects are stomach-related: diarrhea, nausea, and upset stomach. Taking the tablet with meals can help. Swallow the ER tablet whole; do not crush, cut, or chew it. Long-term use may lower vitamin B12 levels, so your provider may check this over time. This information is not medical advice. Talk with your doctor or pharmacist about your full health history and any other medicines you take.

Sources & accuracy

This Metformin Hcl Er (Mod) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Metformin Hcl Er (Mod) on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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