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Calcitriol

Calcitriol 0.25MCG

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What is Calcitriol?

Calcitriol is the active form of vitamin D3, crucial for the absorption of calcium and phosphate in the body, which are vital for maintaining healthy bones and teeth. It is commonly used in the treatment of conditions caused by low levels of calcium or phosphate, such as hypoparathyroidism, chronic kidney disease, and rickets. Calcitriol works by promoting calcium absorption in the intestines and retention at the kidneys, thus managing calcium levels in the bloodstream and bone metabolism.

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What is Calcitriol ?

Calcitriol is the active form of vitamin D3, crucial for the absorption of calcium and phosphate in the body, which are vital for maintaining healthy bones and teeth. It is commonly used in the treatment of conditions caused by low levels of calcium or phosphate, such as hypoparathyroidism, chronic kidney disease, and rickets. Calcitriol works by promoting calcium absorption in the intestines and retention at the kidneys, thus managing calcium levels in the bloodstream and bone metabolism.

  • Severe stomach pain, metallic taste in your mouth
  • Cloudy or foaming urine
  • Irregular heartbeat
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Seizures
  • Bone or muscle pain
  • Nausea and vomiting, long-lasting headache, constipation, sleepiness, weakness
  • Seizures
  • Do not use more calcitriol than your doctor ordered. Too much of this medicine may cause a dangerous amount of calcium to build up in your body.
  • If you are not on dialysis, drink extra liquids to prevent dehydration. Ask your doctor how much liquid to drink each day.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Nausea and vomiting, long-lasting headache, constipation, sleepiness, weakness
  • Severe stomach pain, metallic taste in your mouth
  • Tell your doctor if you are pregnant, breastfeeding, or have any medical problems.
What is calcitriol used for?
Calcitriol manages low blood calcium (hypocalcemia) and elevated parathyroid hormone (secondary hyperparathyroidism) in people with chronic kidney disease, including those on dialysis and those not yet on dialysis. It also treats hypocalcemia in hypoparathyroidism and pseudohypoparathyroidism and is used for metabolic bone disease such as renal osteodystrophy. The topical form, Vectical, is approved for mild-to-moderate plaque psoriasis.
Is calcitriol the same as vitamin D?
Not exactly. Calcitriol is the active form of vitamin D3 (1,25-dihydroxycholecalciferol) that the body normally makes in the kidneys. Ordinary supplements like cholecalciferol (D3) and ergocalciferol (D2) must be activated by the liver and kidneys first. Calcitriol is already active, so it works even when failing kidneys cannot complete that step, which is why it is prescribed rather than bought over the counter.
What are the side effects of calcitriol?
The most important side effects come from too much calcium. Early signs include weakness, headache, nausea, vomiting, dry mouth, constipation, a metallic taste, muscle or bone pain, and loss of appetite. More serious signs include confusion, irregular heartbeat, and calcium deposits in soft tissue or blood vessels. Your provider monitors your calcium, phosphorus, and PTH regularly to catch problems early. Report any of these symptoms to your care team.
What foods or products should you avoid while taking calcitriol?
Do not take pharmacologic doses of other vitamin D products at the same time, and avoid magnesium-containing antacids if you are on dialysis because of the risk of high magnesium. Calcium supplements and phosphate binders should only be used as directed, since combining them with calcitriol raises the risk of high calcium. Ask your provider before making changes to a high-calcium diet or supplements while on this medicine.
How long does it take for calcitriol to work?
Calcitriol begins raising blood calcium fairly quickly, but the full effect on calcium and parathyroid hormone levels is judged over days to weeks through lab monitoring. Because dosing is adjusted to your blood test results, do not change your dose on your own. Your provider will fine-tune it based on your calcium, phosphorus, and PTH levels.
How much does Calcitriol cost without insurance?
The price of Calcitriol without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Calcitriol?
Common side effects of Calcitriol may include: Severe stomach pain, metallic taste in your mouth, Cloudy or foaming urine, Irregular heartbeat, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Seizures. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Calcitriol?
Generic versions may be available for Calcitriol. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Calcitriol 0.25MCG on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Calcitriol?
The cheapest pharmacy for Calcitriol depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Calcitriol 0.25MCG near you.

Calcitriol Coupons & Prices

Calcitriol 0.25MCG

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Calcitriol Capsule — prescription drug image
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Calcitriol 0.25mcg (36)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Looking for a calcitriol coupon? Calcitriol is the active form of vitamin D3, prescribed to manage low calcium and elevated parathyroid hormone in people with chronic kidney disease, hypoparathyroidism, and related bone conditions. It is available as an affordable FDA-approved generic, but the cash price still varies widely from one pharmacy to another, so comparing before you fill can make a real difference. Rx.com checks prices across more than 60,000 pharmacies and provides a free discount coupon you can use whether or not you have insurance. Enter your ZIP above to see today's price near you.

What is calcitriol and how does it work?

Calcitriol (brand names Rocaltrol and Calcijex, plus the topical form Vectical) is a vitamin D analog. It is the biologically active form of vitamin D3, known chemically as 1,25-dihydroxycholecalciferol. Unlike ordinary vitamin D supplements, calcitriol is already "switched on," so it works even when the kidneys can no longer complete the final activation step, as happens in chronic kidney disease.

By helping the body absorb calcium from food and regulating parathyroid hormone (PTH), calcitriol treats hypocalcemia (low blood calcium) and secondary hyperparathyroidism in people with chronic kidney disease, including those on dialysis and those not yet on dialysis. It is also used for hypocalcemia in hypoparathyroidism and pseudohypoparathyroidism and for metabolic bone disease such as renal osteodystrophy. The topical cream Vectical is FDA-approved for mild-to-moderate plaque psoriasis.

Calcitriol cost and coupon savings

Calcitriol is available as a substitutable generic, which usually keeps its cost lower than a brand-name product. Even so, the cash price is not the same everywhere. Pharmacies set their own prices, so the amount you pay for the exact same capsule can differ substantially between two stores in the same town. That is why comparing prices before you fill is worth the few seconds it takes.

Rx.com compares calcitriol prices across more than 60,000 U.S. pharmacies and gives you a free coupon that works with or without insurance. If you do not have prescription coverage, or your plan does not cover this drug well, a discount coupon may cost less than your copay. Enter your ZIP code above to see today's price at pharmacies near you and print or show the coupon at the counter.

Calcitriol vs. the brand and similar medicines

Calcitriol is the generic of Rocaltrol. Because the generic is FDA-approved and substitutable, most people can fill it in place of the brand and pay less. Your prescriber and pharmacist can confirm which form is right for you.

Depending on your condition, your doctor may consider other vitamin D analogs or related medicines used for kidney-related bone and mineral disorders. These are prescribed and monitored differently, so any switch is a decision for your care team, not a self-serve swap. Related options include:

Safety, side effects, and monitoring

Calcitriol has no boxed warning. Its main risk is too much calcium in the blood or urine (hypercalcemia and hypercalciuria). Early signs can include weakness, headache, nausea, vomiting, dry mouth, constipation, a metallic taste, muscle or bone pain, and loss of appetite. Later or more serious signs include confusion, irregular heartbeat, and calcium deposits in soft tissue or blood vessels, a risk that rises when calcitriol is combined with calcium supplements or phosphate binders. Because of this, your provider will regularly check your serum calcium, phosphorus, and PTH levels.

Calcitriol should not be used if you have high blood calcium or vitamin D toxicity. Avoid magnesium-containing antacids while on dialysis (risk of high magnesium) and do not take pharmacologic doses of other vitamin D products at the same time. Use caution with digoxin, since high calcium can worsen heart-rhythm problems, and note that calcitriol can affect growth in children. This is general information, not medical advice, so follow your provider's instructions and report any of these symptoms promptly.

Sources & accuracy

This Calcitriol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Calcitriol on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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