Febuxostat
Febuxostat 40MG
What is Febuxostat?
Febuxostat is a medication used to treat gout in adults who have not had success with other treatments. It helps lower uric acid levels in the body, which can cause painful gout attacks.Side Effects
- Sudden or severe headache, problems with vision, speech, or walking.
- Yellowing of your skin or the whites of your eyes.
- Unusual bleeding, bruising, or weakness.
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, brain or blood vessel disease, diabetes, Lesch-Nyhan syndrome (rare, inherited enzyme problem), cancer, or a history of heart disease or stroke. Tell your doctor if you had an organ transplant.
- This medicine may cause the following problems:Increased risk for chest pain, heart attack, stroke, or deathLiver problemsSerious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS)
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Dark-colored urine or pale stools.
Prescription savings · · · ·
What is Febuxostat ?
Febuxostat is a medication used to treat gout in adults who have not had success with other treatments. It helps lower uric acid levels in the body, which can cause painful gout attacks.- Sudden or severe headache, problems with vision, speech, or walking.
- Yellowing of your skin or the whites of your eyes.
- Unusual bleeding, bruising, or weakness.
- Unusual bleeding, bruising, or weakness
- Sudden or severe headache, problems with vision, speech, or walking
- Swollen, painful, or tender lymph glands in the neck, armpit, or groin
- Swelling in your hands, ankles, or feet.
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Change in how much or how often you urinate, cloudy urine
- Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, faintness, coughing up blood
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Fever, chills, cough, sore throat, body aches
- Joint or muscle pain
- Numbness or weakness in your arm or leg, or on one side of your body
- Pain in your lower leg (calf)
- Swelling in your hands, ankles, or feet
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, brain or blood vessel disease, diabetes, Lesch-Nyhan syndrome (rare, inherited enzyme problem), cancer, or a history of heart disease or stroke. Tell your doctor if you had an organ transplant.
- This medicine may cause the following problems:Increased risk for chest pain, heart attack, stroke, or deathLiver problemsSerious skin reactions, including drug reaction with eosinophilia and systemic symptoms (DRESS)
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Dark-colored urine or pale stools.
- Dry mouth, increased thirst, or muscle cramps.
- Fast, slow, or uneven heartbeat.
- Fever, chills, cough, sore throat, and body aches.
- Joint or muscle pain.
- Lightheadedness or fainting.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain in your lower leg (calf).
- Sudden and severe stomach pain, nausea, or vomiting.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding, bruising, or weakness.
- Yellowing of your skin or the whites of your eyes.
Febuxostat Coupons & Prices
Febuxostat 40MG
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Looking for a febuxostat coupon? Febuxostat is the generic version of Uloric, a daily urate-lowering medicine used for the long-term management of gout. Because it is available as a generic, febuxostat is often already low-cost, but the cash price can vary widely from one pharmacy to the next, so comparing before you fill can make a real difference. Rx.com compares prices at more than 60,000 pharmacies so you can find a low price near you. Enter your ZIP above to see today's price and print or show your free Rx.com discount at the pharmacy counter.
What is febuxostat and how does it work?
Febuxostat is a xanthine oxidase inhibitor, a type of urate-lowering therapy. It is FDA-approved for the chronic (long-term) management of hyperuricemia (high uric acid) in adults with gout. It works by lowering the amount of uric acid your body makes, which over time helps prevent gout flares and the buildup of tophi (uric acid deposits). It is a preventive, daily medicine, not a treatment for a gout attack that is already happening.
Because of a 2019 FDA safety restriction, febuxostat is reserved for people who have not gotten enough benefit from, or cannot tolerate, a fully titrated dose of allopurinol. It is not typically a first-choice medicine for gout.
Febuxostat cost and coupon savings without insurance
Febuxostat is a generic, so it is generally more affordable than the brand Uloric. Even so, the cash price is not the same everywhere. Different pharmacies set their own prices, and the gap between the highest and lowest price in the same town can be surprisingly large. That is why it pays to compare rather than assume your usual pharmacy has the best deal.
If you are paying without insurance, or if the cash price with an Rx.com discount beats your copay, a discount can help. Enter your ZIP above to see today's price at pharmacies near you. Rx.com compares more than 60,000 pharmacies, and the discount is free to use.
Febuxostat vs. allopurinol and other gout medicines
Febuxostat and allopurinol both lower uric acid, but current guidance treats allopurinol as the usual first choice; febuxostat is reserved for people who failed or could not tolerate a maximized allopurinol dose. Other gout-related medicines work differently:
- Colchicine and NSAIDs are often used to prevent or treat the flares that can happen when you first start a urate-lowering medicine.
- Probenecid helps the body remove more uric acid through the urine, rather than reducing how much is made.
- Pegloticase is an infusion option for severe gout that has not responded to other therapies.
Your prescriber will choose the right option based on your kidney function, heart health, and how you have responded to past treatment. This is general information, not medical advice.
Safety and important warnings
Febuxostat carries a boxed warning: in a large trial (CARES), it was linked to a higher risk of cardiovascular death and all-cause death compared with allopurinol. For this reason it is reserved for patients who cannot use allopurinol. Tell your provider if you have heart disease or a history of stroke, and do not stop or start it on your own.
Other things to know: gout flares are common when you begin the medicine, so your provider may prescribe an NSAID or colchicine for a while to help prevent them. Febuxostat can raise liver enzymes, so periodic blood tests to check the liver are recommended. Rare but serious skin reactions (such as SJS or DRESS) can occur, so report any rash, fever, or blistering right away. Febuxostat does not treat an acute gout attack. Always read the Medication Guide and talk with your provider or pharmacist about your personal risks.
This Febuxostat information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Febuxostat on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.