Naproxen-Esomeprazole Mg Coupons & Prices

Looking for a naproxen-esomeprazole coupon? Naproxen and esomeprazole magnesium delayed-release tablets are the generic version of Vimovo, a single tablet that pairs the anti-inflammatory naproxen with the acid-reducing proton pump inhibitor esomeprazole. Even though a generic is available, the cash price still swings a lot from one pharmacy to the next, so the pharmacy you choose can matter more than the coupon itself. Enter your ZIP code above to compare today's price with an Rx.com discount coupon at more than 60,000 pharmacies near you, then show the coupon at the counter. The coupon is free to use and works whether or not you have insurance.

What is naproxen and esomeprazole magnesium, and how does it work?

Naproxen and esomeprazole magnesium is a fixed-dose combination delayed-release tablet. The core of the tablet is enteric-coated naproxen (375 mg or 500 mg), a non-selective nonsteroidal anti-inflammatory drug, or NSAID, that eases pain, swelling, and stiffness. Wrapped around it is an immediate-release layer of esomeprazole 20 mg, a proton pump inhibitor (PPI) that lowers stomach acid. The esomeprazole is released first so it can start reducing acid before the naproxen is absorbed further down in the gut.

Per the current Vimovo label this generic references, the combination is indicated in adult and adolescent patients 12 years of age and older who weigh at least 38 kg, when they need naproxen for symptomatic relief of arthritis and esomeprazole to decrease the risk of developing naproxen-associated gastric ulcers. The naproxen component is indicated for relief of the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis in adults, and of juvenile idiopathic arthritis (JIA) in adolescent patients. Safety and effectiveness have not been established in children under 12 years of age or under 38 kg.

It is taken twice a day, and the tablets are swallowed whole with liquid at least 30 minutes before meals. The strength depends on weight: adolescents 12 and older weighing 38 kg to less than 50 kg take one 375 mg/20 mg tablet twice daily, while adults and adolescents over 50 kg may take either the 375 mg/20 mg or the 500 mg/20 mg tablet twice daily. Because the naproxen is enteric-coated and absorbed slowly, this product is not recommended for the initial treatment of sudden, acute pain, and controlled studies of it do not extend beyond 6 months. Your prescriber decides whether it is right for you and which strength to use.

Cost without insurance, and why comparing pharmacies matters

The generic is what most people fill today, but that does not automatically mean a low price at the register. This is a twice-daily, chronic medication, and pharmacies set their own cash prices, so the spread between two stores on the same street can be large. What you pay for the brand versus the generic, and at one pharmacy versus another, varies, so the useful step is comparing prices rather than assuming any one option is cheapest.

• Enter your ZIP above to see today's coupon price at pharmacies near you before you drive anywhere.
• Ask the pharmacy to run the Rx.com coupon instead of insurance if the cash price comes out lower; the discount is not insurance and cannot be combined with it.
• Ask your prescriber whether a 90-day supply is appropriate for you, since fill size can change what you pay per tablet.
• There is no manufacturer copay savings card for this generic. Any brand program terms would come from the manufacturer's own website and change over time.

Prices update frequently, so it is worth checking again on refill day rather than assuming last month's price still applies.

Alternatives and how they compare

One alternative your prescriber may consider is taking the two ingredients as separate prescriptions: an NSAID plus a stomach-protecting PPI, such as naproxen with omeprazole or esomeprazole (brand Nexium). Prices for that route vary by pharmacy and are worth comparing rather than assuming. Important: the label specifically says not to substitute this combination tablet with the single-ingredient products of naproxen and esomeprazole on your own, because the combination is formulated to release them in a particular order. That switch is a prescriber decision. The trade-off is convenience and adherence: the combination is one pill, so the acid protection is not forgotten, but the doses are fixed and cannot be adjusted individually.

Other NSAIDs your prescriber may consider for arthritis pain include meloxicam, diclofenac, ibuprofen, and the COX-2 selective option celecoxib. These are not interchangeable, and each carries its own NSAID risks. Never switch or stack NSAIDs on your own; the label says not to use this product with other naproxen-containing products or other non-aspirin NSAIDs, and taking another NSAID or aspirin along with it raises the risk of stomach bleeding. Talk with your prescriber or pharmacist about which approach fits your health history and your budget.

Safety, warnings, and side effects

Naproxen and esomeprazole magnesium carries a two-part FDA boxed warning. First, cardiovascular thrombotic events: NSAIDs increase the risk of serious and potentially fatal events including heart attack and stroke. That risk can occur early in treatment and may increase with duration of use. It must not be used in the setting of coronary artery bypass graft (CABG) surgery. Second, gastrointestinal bleeding, ulceration, and perforation: NSAIDs increase the risk of serious stomach and intestinal events that can happen at any time, without warning signs, and can be fatal. Older adults and people with a history of peptic ulcer disease or GI bleeding are at greatest risk. The esomeprazole component is indicated only to decrease the risk of naproxen-associated gastric ulcers; it lowers, but does not remove, that risk, and it has not been shown to reduce the risk of duodenal ulcers.

The label lists four contraindications. Do not use it if you have a known hypersensitivity to naproxen, to esomeprazole magnesium, to substituted benzimidazoles, or to any component of the product including omeprazole; if aspirin or other NSAIDs have ever triggered asthma, hives, or an allergic-type reaction; in the setting of CABG surgery; or if you are taking a rilpivirine-containing product, because PPIs including esomeprazole are contraindicated with rilpivirine. On pregnancy, the label says to limit NSAID use between about 20 and 30 weeks because of the risk of low amniotic fluid and fetal kidney problems, and to avoid NSAIDs at about 30 weeks of pregnancy and later.

Other label warnings include high blood pressure, new or worsening heart failure and swelling, kidney injury, liver injury, serious or severe skin reactions and DRESS, anemia and easier bleeding, anaphylactic reactions, and fever or inflammation being masked. With long-term PPI use, the label also notes acute tubulointerstitial nephritis, C. difficile-associated diarrhea, bone fractures with long-term multiple-daily-dose therapy, low magnesium, low vitamin B-12, lupus-like reactions, and fundic gland polyps. Tell your prescriber about all your medicines, since interactions include rilpivirine, clopidogrel, blood thinners, SSRIs and SNRIs, steroids, methotrexate, lithium, diuretics and blood-pressure medicines, cyclosporine, digoxin, St. John's wort or rifampin, and drugs that need stomach acid to be absorbed. Swallow tablets whole with liquid at least 30 minutes before a meal; do not split, crush, chew, or dissolve them. Use the lowest naproxen dose that works, for the shortest time needed. This is general information, not medical advice; talk with your provider or pharmacist about your own situation.