Naproxen

Prescriptions & Refills

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What is Naproxen?

Prescription-strength naproxen is an NSAID (nonsteroidal anti-inflammatory drug) used to treat pain, inflammation, and stiffness from conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, bursitis, tendinitis, menstrual cramps, and acute gout. Unlike lower-dose OTC versions, prescription naproxen is available in higher strengths (up to 500 mg tablets) for more significant pain and inflammation. Naproxen works by blocking COX-1 and COX-2 enzymes that produce prostaglandins — the chemicals that drive pain and swelling. A key advantage is its longer duration of action, allowing twice-daily dosing instead of three or four times daily. A licensed provider can prescribe naproxen online through Rx.com if it is appropriate for your condition. You can also use the Rx.com coupon to save significantly on the cost at your local pharmacy.

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Blistering, peeling, red skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
Chest pain that may spread, trouble breathing, unusual sweating, fainting
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Bloody or black, tarry stools, severe stomach pain, vomiting blood or something that looks like coffee grounds
Rapid weight gain, swelling in your hands, ankles, or feet
Change in how much or how often you urinate, painful or difficult urination
Unusual bleeding, bruising, or weakness
Fever, chills, cough, sore throat, body aches
Vision changes

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.
This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Tell any doctor or dentist who treats that you are using this medicine, especially if you have surgery or a procedure.
Call your doctor if symptoms get worse, pain lasts more than 10 days, or fever lasts more than 3 days.
This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsKidney problemsHigh blood pressureSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, high blood pressure, heart failure, a recent heart attack, or a history of stomach or bowel problems (including ulcers or bleeding). Tell your doctor if you smoke or drink alcohol.

How much does Naproxen cost without insurance? ▼

The price of Naproxen without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.

What are the common side effects of Naproxen? ▼

Common side effects of Naproxen may include: Blistering, peeling, red skin rash, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking, Chest pain that may spread, trouble breathing, unusual sweating, fainting, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.

Is there a generic version of Naproxen? ▼

Generic versions may be available for Naproxen. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Naproxen on Rx.com to compare generic and brand prices at pharmacies near you.

What is the cheapest pharmacy for Naproxen? ▼

The cheapest pharmacy for Naproxen depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Naproxen near you.

Naproxen Coupons & Prices

Naproxen

What is Naproxen ?

Prescriptions & Refills

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Prescription

Naproxen 500mg (60)

43215 ·

Name

Form

Dosage

Quantity

43215 Change ZIP

What Is Prescription Naproxen?

Naproxen sodium and naproxen base are prescription-strength NSAIDs that reduce pain, fever, and inflammation. While lower-dose naproxen is sold OTC (as Aleve), prescription naproxen — at 375 mg or 500 mg doses — delivers stronger, longer-lasting relief for chronic and acute inflammatory conditions.

Conditions Treated

Rheumatoid arthritis — reduces joint inflammation, pain, and morning stiffness
Osteoarthritis — eases pain and improves joint function
Ankylosing spondylitis — controls chronic spinal inflammation
Acute gout attacks — rapidly reduces joint swelling and pain
Bursitis and tendinitis — decreases soft-tissue inflammation
Dysmenorrhea — relieves menstrual cramps

How Does Naproxen Work?

Naproxen inhibits both COX-1 and COX-2 cyclooxygenase enzymes, blocking the production of prostaglandins and thromboxanes that sensitize nerves and cause swelling. Its relatively long half-life (~12–17 hours) allows effective relief with just twice-daily dosing.

Dosage Overview

Arthritis (chronic): 250 mg–500 mg twice daily
Acute pain / dysmenorrhea: 500 mg initially, then 500 mg every 12 hours or 250 mg every 6–8 hours
Acute gout: 750 mg initially, then 250 mg every 8 hours until attack subsides

Naproxen should be taken with food or milk to reduce stomach irritation.

Safety Considerations

Like all NSAIDs, naproxen carries a boxed warning for increased risk of heart attack, stroke, and GI bleeding. It should be avoided by people with a history of cardiovascular disease, active GI ulcers, or severe kidney disease.

Save on Naproxen

Prescription naproxen is a generic drug and very affordable. With a free Rx.com coupon, 60 tablets (500 mg) can cost as little as $8–$15 at many pharmacies.