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Naproxen

Naproxen

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What is Naproxen?

Prescription-strength naproxen is an NSAID (nonsteroidal anti-inflammatory drug) used to treat pain, inflammation, and stiffness from conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, bursitis, tendinitis, menstrual cramps, and acute gout. Unlike lower-dose OTC versions, prescription naproxen is available in higher strengths (up to 500 mg tablets) for more significant pain and inflammation. Naproxen works by blocking COX-1 and COX-2 enzymes that produce prostaglandins — the chemicals that drive pain and swelling. A key advantage is its longer duration of action, allowing twice-daily dosing instead of three or four times daily. A licensed provider can prescribe naproxen online through Rx.com if it is appropriate for your condition. You can also use the Rx.com coupon to save significantly on the cost at your local pharmacy.

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What is Naproxen ?

Prescription-strength naproxen is an NSAID (nonsteroidal anti-inflammatory drug) used to treat pain, inflammation, and stiffness from conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, bursitis, tendinitis, menstrual cramps, and acute gout. Unlike lower-dose OTC versions, prescription naproxen is available in higher strengths (up to 500 mg tablets) for more significant pain and inflammation. Naproxen works by blocking COX-1 and COX-2 enzymes that produce prostaglandins — the chemicals that drive pain and swelling. A key advantage is its longer duration of action, allowing twice-daily dosing instead of three or four times daily. A licensed provider can prescribe naproxen online through Rx.com if it is appropriate for your condition. You can also use the Rx.com coupon to save significantly on the cost at your local pharmacy.
  • Blistering, peeling, red skin rash
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Chest pain that may spread, trouble breathing, unusual sweating, fainting
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Bloody or black, tarry stools, severe stomach pain, vomiting blood or something that looks like coffee grounds
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Change in how much or how often you urinate, painful or difficult urination
  • Unusual bleeding, bruising, or weakness
  • Fever, chills, cough, sore throat, body aches
  • Vision changes
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Tell any doctor or dentist who treats that you are using this medicine, especially if you have surgery or a procedure.
  • Call your doctor if symptoms get worse, pain lasts more than 10 days, or fever lasts more than 3 days.
  • This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsKidney problemsHigh blood pressureSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
  • Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, high blood pressure, heart failure, a recent heart attack, or a history of stomach or bowel problems (including ulcers or bleeding). Tell your doctor if you smoke or drink alcohol.
Is naproxen the same as Aleve?
They are the same active ingredient. Aleve is an over-the-counter brand of naproxen sodium used for temporary relief of minor aches, pains, and fever. Prescription naproxen (including brands like Naprosyn, Anaprox DS, EC-Naprosyn, and Naprelan) generally comes in higher strengths and additional forms and is used for conditions such as arthritis, gout attacks, and menstrual cramps. Follow your provider's or the label's directions for the product you have.
What is naproxen used for?
Prescription naproxen relieves pain, tenderness, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. It also treats tendinitis, bursitis, acute gout attacks, menstrual cramps, and general mild-to-moderate pain. The over-the-counter version (Aleve) is used for temporary relief of minor aches, pains, and fever.
Can you take naproxen and ibuprofen together?
No. Naproxen and ibuprofen are both NSAIDs, and you should not combine naproxen with other NSAIDs. Taking two NSAIDs together raises the risk of serious side effects such as stomach bleeding and kidney problems without added benefit. Ask your provider or pharmacist before combining pain relievers.
How long does naproxen take to work?
This varies by person and by the form of naproxen. Enteric-coated and extended-release forms release the medicine more slowly. For questions about timing and dosing for your specific situation, check your prescription label and ask your provider or pharmacist. This is general information and not medical advice.
What are the serious side effects of naproxen?
The most serious risks are heart-related blood-clot events such as heart attack and stroke, and gastrointestinal bleeding, ulcers, or perforation, which can be fatal and may occur without warning. Naproxen can also cause kidney injury, fluid retention and swelling, high blood pressure, and allergic reactions. Older adults and people with heart disease or a history of ulcers face higher risk. Seek medical help right away for chest pain, trouble breathing, black or bloody stools, or signs of a severe allergic reaction.
How much does Naproxen cost without insurance?
The price of Naproxen without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Naproxen?
Common side effects of Naproxen may include: Blistering, peeling, red skin rash, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking, Chest pain that may spread, trouble breathing, unusual sweating, fainting, Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Naproxen?
Generic versions may be available for Naproxen. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Naproxen on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Naproxen?
The cheapest pharmacy for Naproxen depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Naproxen near you.

Naproxen Coupons & Prices

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Naproxen Tablet — prescription drug image
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Looking for a naproxen coupon? Naproxen is a low-cost generic prescription NSAID (the same medicine sold over the counter as Aleve), but the cash price still varies widely from one pharmacy to the next, so comparing before you fill can make a real difference. Rx.com compares naproxen prices across more than 60,000 pharmacies so you can enter your ZIP above to see today's price near you and bring a free discount coupon to the counter.

What is naproxen and how does it work?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid class. It works by lowering the substances in the body that cause pain, inflammation, and fever. Prescription naproxen is used to relieve pain, tenderness, swelling, and stiffness from osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis. It is also used to treat tendinitis, bursitis, acute gout attacks (acute gouty arthritis), menstrual cramps (dysmenorrhea), and general mild-to-moderate pain.

Prescription naproxen comes in several forms, including the brands Naprosyn, Anaprox DS, EC-Naprosyn (enteric-coated), and Naprelan (extended-release). The over-the-counter version, naproxen sodium (Aleve), is used for the temporary relief of minor aches, pains, and fever. Your prescriber will choose the form and strength that fits your situation.

How much does naproxen cost without insurance?

Naproxen is available as a generic, which usually keeps it among the more affordable prescription NSAIDs. Even so, the cash price without insurance can differ a lot depending on which pharmacy you use, the form (immediate-release, enteric-coated, or extended-release), and your quantity. Because two pharmacies across the street from each other can charge very different amounts, comparing prices is worth the few seconds it takes.

Enter your ZIP above to see today's naproxen price at pharmacies near you. The Rx.com discount coupon is free to use, requires no insurance, and can be shown right at the pharmacy counter. You do not need a manufacturer savings card for generic naproxen.

Naproxen alternatives and related NSAIDs

Naproxen is one of several NSAIDs used for pain and inflammation. If naproxen is not the right fit, your provider may consider another option. Related and commonly compared medicines include:

  • ibuprofen — another over-the-counter and prescription NSAID
  • meloxicam — a once-daily NSAID often used for arthritis
  • diclofenac — available as tablets and topical gel
  • celecoxib — a COX-2 selective NSAID
  • indomethacin — often used for gout and inflammatory conditions
  • nabumetone — another prescription NSAID for arthritis

Do not combine naproxen with other NSAIDs, and talk with your provider or pharmacist before switching or adding a pain reliever. Whichever medicine you are prescribed, you can compare its price on Rx.com.

Naproxen safety and side effects

Naproxen carries two boxed warnings, the FDA's strongest. First, NSAIDs can increase the risk of serious cardiovascular blood-clot events, including heart attack and stroke, which can be fatal; the risk rises with longer use and in people with heart disease or its risk factors, and naproxen should not be used for pain right before or after heart bypass (CABG) surgery. Second, NSAIDs can cause serious gastrointestinal bleeding, ulcers, and tears in the stomach or intestines, which can happen without warning and can be fatal; older adults and those with a prior ulcer or GI bleed are at greatest risk.

Naproxen can also affect the kidneys, cause fluid retention or swelling, raise blood pressure, and trigger allergic reactions. It should be avoided in the third trimester of pregnancy. This is general information, not medical advice. Tell your provider about your health history and other medicines, use the lowest effective dose for the shortest time needed, and contact them right away if you notice signs of stomach bleeding, chest pain, shortness of breath, or a severe allergic reaction.

Sources & accuracy

This Naproxen information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Naproxen on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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