Naproxen Dr
Naproxen DR 500MG
What is Naproxen Dr?
Naproxen DR (delayed release) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation associated with conditions such as arthritis, tendinitis, and bursitis. By inhibiting the production of prostaglandins, chemicals in the body responsible for pain and inflammation, Naproxen DR provides extended relief through its delayed-release formulation designed for once or twice-a-day dosing. It is important to use Naproxen DR as prescribed and under medical supervision to minimize potential gastrointestinal and cardiovascular side effects.Side Effects
- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Naproxen Dr ?
Naproxen DR (delayed release) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation associated with conditions such as arthritis, tendinitis, and bursitis. By inhibiting the production of prostaglandins, chemicals in the body responsible for pain and inflammation, Naproxen DR provides extended relief through its delayed-release formulation designed for once or twice-a-day dosing. It is important to use Naproxen DR as prescribed and under medical supervision to minimize potential gastrointestinal and cardiovascular side effects.- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Chest pain that may spread, trouble breathing, unusual sweating, fainting
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or something that looks like coffee grounds
- Rapid weight gain, swelling in your hands, ankles, or feet
- Change in how much or how often you urinate, painful or difficult urination
- Unusual bleeding, bruising, or weakness
- Fever, chills, cough, sore throat, body aches
- Vision changes
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats that you are using this medicine, especially if you have surgery or a procedure.
- Call your doctor if symptoms get worse, pain lasts more than 10 days, or fever lasts more than 3 days.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsKidney problemsHigh blood pressureSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, high blood pressure, heart failure, a recent heart attack, or a history of stomach or bowel problems (including ulcers or bleeding). Tell your doctor if you smoke or drink alcohol.
Naproxen Dr Coupons & Prices
Naproxen DR 500MG
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Naproxen Dr prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 500mg · Tablet Delayed Release | 20 | $58.09 | $44.42 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a naproxen delayed-release (naproxen-dr) coupon? Naproxen DR is the enteric-coated, delayed-release form of naproxen (brand name EC-Naprosyn), a prescription NSAID used for long-term relief of arthritis and other chronic inflammatory conditions. It is available as a low-cost generic, but the cash price can vary a lot from one pharmacy to the next, so it pays to compare. Rx.com checks prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP code above to see the current price and print a free discount coupon.
What is naproxen delayed-release and how does it work?
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid class. It works by lowering the substances in your body that cause inflammation, pain, and swelling. The delayed-release (DR) tablet has an enteric coating that keeps the tablet from dissolving in the stomach, so the medicine is released later, in the intestine. Sold under the brand name EC-Naprosyn, naproxen DR is FDA-approved for the signs and symptoms of chronic inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile arthritis.
Because the enteric coating delays absorption, this formulation is meant for ongoing, long-term treatment. It is not designed for conditions that need fast pain relief. Your provider will decide whether the delayed-release form or regular naproxen is right for you.
How much does naproxen DR cost without insurance?
Naproxen DR is available as a generic, and generics are generally much less expensive than brand-name EC-Naprosyn. Even so, the cash price you pay without insurance can differ widely between pharmacies for the exact same tablet, which is why comparing before you fill is worth the few seconds it takes. A discount coupon can often beat the standard shelf price, and in many cases a free Rx.com coupon costs you nothing to use.
Rx.com compares prices across more than 60,000 U.S. pharmacies so you do not have to call around. Enter your ZIP code above to see today's price at pharmacies near you and print or text yourself a free coupon. The discount card is free and does not require insurance.
Naproxen DR vs. other NSAID options
Naproxen comes in more than one form. If you need faster relief, your provider may prescribe regular (non-delayed-release) naproxen or naproxen sodium, which are also used for tendinitis, bursitis, acute gout, menstrual cramps, and mild-to-moderate pain. Other prescription NSAIDs your provider might consider include meloxicam, diclofenac, and the COX-2 selective option celecoxib. Over-the-counter ibuprofen is another NSAID many people use for shorter-term pain.
Each of these differs in how it is taken, how long it lasts, and its side-effect profile, so the best choice depends on your condition and health history. Whichever your provider chooses, you can compare cash prices for it on Rx.com and use a free coupon at checkout.
Safety information you should know
Naproxen carries two FDA boxed warnings that apply to NSAIDs. First, a cardiovascular thrombotic risk: NSAIDs can raise the chance of serious and sometimes fatal heart events such as heart attack and stroke; this risk may begin early and can increase the longer the drug is used. Naproxen should not be used to treat pain right before or after coronary artery bypass graft (CABG) surgery. Second, a gastrointestinal risk: NSAIDs can cause serious GI bleeding, ulcers, and tears in the stomach or intestines, which can happen at any time, without warning, and can be fatal. Older adults and people with a history of GI problems are at higher risk.
Other risks include high blood pressure, fluid retention or heart failure, kidney injury, liver problems, serious skin reactions, and allergic reactions. Naproxen should be avoided in the third trimester of pregnancy. Use the lowest effective dose for the shortest time needed. This is general information, not medical advice; talk with your doctor or pharmacist about whether naproxen DR is right for you.
This Naproxen Dr information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Naproxen Dr on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.