Sumatriptan-Naproxen Sodium
Sumatriptan-Naproxen Sodium
What is Sumatriptan-Naproxen Sodium?
Sumatriptan-Naproxen Sodium is a combination medication used to treat migraine headaches once they have started. Sumatriptan, a selective serotonin receptor agonist, works by narrowing blood vessels around the brain and reduces substances in the body that can trigger headache pain, nausea, and sensitivity to light and sound. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), helps to reduce inflammation and pain.
Side Effects
- Coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
- Seizure
- Unusual bleeding, bruising, or weakness
Warnings
- Sudden or severe headache, problems with vision, speech, or walking
- Unexplained weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor says it is okay.
- Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, diabetes, fluid retention, high cholesterol, heart rhythm problems, high blood pressure, or a family history of heart disease. Tell your doctor if you have a history of seizures, ulcers, or stomach or bowel bleeding. Tell your doctor if you are on a low-salt diet or if you smoke or drink alcohol.
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What is Sumatriptan-Naproxen Sodium ?
Sumatriptan-Naproxen Sodium is a combination medication used to treat migraine headaches once they have started. Sumatriptan, a selective serotonin receptor agonist, works by narrowing blood vessels around the brain and reduces substances in the body that can trigger headache pain, nausea, and sensitivity to light and sound. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), helps to reduce inflammation and pain.
- Coughing up blood, numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
- Seizure
- Unusual bleeding, bruising, or weakness
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
- Fast or slow, pounding, or uneven heartbeat
- Unexplained weight gain, swelling in your hands, ankles, or feet
- Chest pain that may spread, trouble breathing, unusual sweating, fainting
- Blistering, peeling, or red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest discomfort, jaw or neck tightness
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Anxiety, restlessness, fever, muscle spasms, diarrhea, seeing or hearing things that are not there
- Change in how much or how often you urinate, painful or difficult urination
- Sudden or severe headache, problems with vision, speech, or walking
- Sudden or severe headache, problems with vision, speech, or walking
- Unexplained weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of pregnancy, unless your doctor says it is okay.
- Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, diabetes, fluid retention, high cholesterol, heart rhythm problems, high blood pressure, or a family history of heart disease. Tell your doctor if you have a history of seizures, ulcers, or stomach or bowel bleeding. Tell your doctor if you are on a low-salt diet or if you smoke or drink alcohol.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, heart rhythm problems, or strokeStomach or bowel problems (including bleeding, ulcers, or perforation)Serotonin syndrome, when used with certain other medicinesKidney problemsLiver problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- Your headaches may become worse if you use a headache medicine for 10 or more days per month. Write down how often your headaches occur and how often you use this medicine.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Severe stomach pain, bloody or black stools
Sumatriptan-Naproxen Sodium Coupons & Prices
Sumatriptan-Naproxen Sodium
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If you are looking for a sumatriptan-naproxen-sodium coupon, Rx.com compares cash prices at more than 60,000 pharmacies so you can see what this migraine tablet costs near you today. Sumatriptan succinate and naproxen sodium is the generic version of Treximet, a single tablet that combines a triptan with an anti-inflammatory pain reliever for the acute treatment of migraine. Cash prices for the generic vary a lot from one pharmacy to the next, even across the street from each other, so comparing before you fill is worth the minute it takes. One thing worth knowing before you start: the manufacturer of Treximet also sells this medicine directly to patients from its own website, and for some people that direct price is lower than any pharmacy cash price we can find. We say more about that below. Enter your ZIP code above to see today's price and print or text yourself a free coupon.
What is sumatriptan and naproxen sodium, and how does it work?
Sumatriptan and naproxen sodium is a fixed-dose combination tablet that puts two different migraine medicines together. Sumatriptan is a serotonin (5-HT1B/1D) receptor agonist, the class commonly called triptans. Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID). The two work through different pathways, which is why they are packaged in one tablet.
It is FDA-approved for the acute treatment of migraine with or without aura in adults and pediatric patients 12 years of age and older. It treats a migraine attack once it has already started. It is not a preventive medicine, and its safety and effectiveness have not been established for cluster headache.
Dosing is not the same for adults and for adolescents, and this is worth reading carefully. In adults, the recommended dose is one 85 mg/500 mg tablet, and the label's maximum is 2 tablets in a 24-hour period, taken at least 2 hours apart. In patients 12 to 17 years of age, the recommended dose per the label is one tablet of the lower 10 mg/60 mg strength, and the maximum in a 24-hour period is 1 tablet of the 85/500 mg strength, not 2. The label also notes that the safety of treating an average of more than 2 migraine headaches in a 30-day period has not been established in pediatric patients. The generic combination tablet is marketed in the 85 mg/500 mg strength; the 10 mg/60 mg strength is a Treximet brand strength. Your prescriber decides which strength and schedule is right for you or your child.
What sumatriptan and naproxen sodium costs without insurance
An FDA-approved generic of this combination tablet in the 85 mg/500 mg strength is approved and marketed. Whether you actually get the generic depends on your prescription and on your state's substitution rules, so ask your pharmacist rather than assuming. It is also worth calling ahead: this is not a tablet every pharmacy keeps on the shelf, and some locations may need to order it for you.
Where it is stocked, cash prices for the same generic tablet, same strength, same quantity, can differ widely between a chain, a grocery pharmacy, and an independent in the same ZIP code. That spread is the whole reason to compare instead of just refilling wherever you filled last time.
Rx.com's free coupon is a cash-discount card, not insurance. You show it at the pharmacy counter and pay the discounted cash price. If you have insurance, it is still worth checking both ways, because the cash price with a coupon is sometimes lower than a copay.
Check the manufacturer's direct option before you fill. Currax, the company behind Treximet, sells both brand Treximet and its authorized generic straight to patients from its official website, Treximet.com, at a flat cash price with a valid prescription, and it offers to look up your insurance coverage as well. For this particular medicine that direct channel is frequently cheaper than what any pharmacy will charge you with our coupon or anyone else's. We would rather tell you that than sell you a worse deal. Compare the manufacturer's direct price against the pharmacy price you see here, and take whichever is lower. Enter your ZIP above to see today's pharmacy price near you.
Alternatives and how it compares
The brand-name version of this exact combination is Treximet. The two ingredients are also sold separately as sumatriptan (brand Imitrex) and naproxen (brand Naprosyn). Some people and their prescribers find the combination tablet more convenient; others do better on one component alone, or on a different triptan. Filling the two ingredients separately is a conversation to have with your prescriber, not something to do on your own, since the doses are not interchangeable with the combination tablet.
Other triptans used for acute migraine include rizatriptan (Maxalt), eletriptan, and zolmitriptan. Response to triptans is individual, and price differences between them can be large, so it is reasonable to ask your prescriber whether a switch makes sense and then compare prices here. Important: do not take another triptan or an ergot-type migraine medicine within 24 hours of this tablet.
Safety information you should know
Sumatriptan and naproxen sodium carries a boxed warning for serious cardiovascular and gastrointestinal events, both tied to the naproxen component. NSAIDs increase the risk of serious cardiovascular thrombotic events, including heart attack and stroke, which can be fatal; that risk may appear early in treatment and increase the longer it is used. It is contraindicated for treating pain around coronary artery bypass graft (CABG) surgery. NSAIDs also raise the risk of serious stomach and intestinal bleeding, ulcers, and perforation, which can be fatal and can happen at any time without warning symptoms; older adults and people with a history of ulcers or GI bleeding are at greatest risk.
This medicine should not be used by people with ischemic coronary artery disease, coronary vasospasm (Prinzmetal angina), Wolff-Parkinson-White syndrome or other arrhythmias with accessory conduction pathways, a history of stroke or TIA, hemiplegic or basilar migraine, peripheral vascular disease, ischemic bowel disease, uncontrolled high blood pressure, severe liver impairment, or asthma or hives after taking aspirin or NSAIDs. Do not use it within 24 hours of another triptan or an ergot-type medicine, or within 2 weeks of an MAO-A inhibitor. Other risks include serotonin syndrome (especially with SSRIs or SNRIs), medication overuse headache if used frequently, raised blood pressure, liver injury, kidney injury, harm to fetal kidneys with use at 20 weeks of pregnancy or later (avoid from 30 weeks on), and severe allergic reactions. This page is information, not medical advice. Talk with your doctor or pharmacist about your own heart, stomach, and kidney history before taking it.
This Sumatriptan-Naproxen Sodium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Sumatriptan-Naproxen Sodium on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.