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Prescription skin care

Prescription Skin Care, From Home

Dermatology's most proven ingredients for acne, fine lines, melasma and dark spots, through a confidential online visit with a U.S.-licensed provider. Rx.com's own skin line is coming soon.

  • Tretinoin for acne and aging
  • Hydroquinone blends for dark spots
  • Provider-reviewed, prescription only
  • Shipped to your door
Prescription Tretinoin

FDA-approved generic (Retin-A)

Prescription Tretinoin

Cream, applied at night

The gold-standard retinoid. Clears acne, smooths fine lines and fades dark marks by speeding up skin renewal.

Coming soon Learn more →
Hydroquinone Blends

Compounded, not FDA-approved

Hydroquinone Blends

Cream, applied at night

Prescription fade creams that pair hydroquinone with tretinoin, niacinamide, vitamin C or kojic acid for melasma and dark spots.

Coming soon Learn more →

Already have a prescription? Compare free coupon prices for tretinoin or hydroquinone.

Prescription strength, when over-the-counter is not enough

Tretinoin is the retinoid with the deepest evidence for acne and sun-related aging: it keeps pores clear, smooths texture and softens fine lines over months.

Hydroquinone is the classic prescription treatment for melasma and dark spots. Since 2020 it can no longer be sold over the counter in the U.S. Prescription blends pair it with tretinoin, niacinamide, vitamin C or kojic acid. Daily sunscreen is what keeps any result.

How it will work

Licensed provider smiling during a video consultation U.S.-licensed providers
1

Online health intake

A short, confidential questionnaire. No appointment, no waiting room.

2

Provider review

A U.S.-licensed provider reviews your answers and prescribes only if treatment is right for you.

3

Delivered to your door

A licensed U.S. pharmacy fills your prescription and ships it to you.

FAQs

Do I need a prescription for tretinoin or hydroquinone?
Yes, both are prescription only in the U.S. A provider can prescribe them after an online visit.
Which one is right for me?
Tretinoin is for acne, fine lines and texture. Hydroquinone blends are for melasma, sun spots and dark marks. Many hydroquinone blends also contain tretinoin. Your provider decides what fits your skin.
Can I use them while pregnant?
Tretinoin and other retinoids are avoided in pregnancy, and hydroquinone is usually avoided too. Tell your provider if you are pregnant, trying or breastfeeding.
When will Rx.com's skin treatments be available?
Soon. Already have a prescription? Compare free coupon prices on the tretinoin and hydroquinone pages.

Articles & Guides

Tretinoin Cream vs Gel: Which Is Better for Your Skin? How Much Does Tretinoin Cost? Prices With and Without Insurance Can You Use Hydroquinone While Pregnant or Breastfeeding? Why Hydroquinone Is Used in Cycles: On-and-Off Treatment Explained Hydroquinone for Dark Underarms and Inner Thighs Tretinoin for Wrinkles: Before and After Results for Anti-Aging Adapalene vs Tretinoin: Which Retinoid Is Right for You? Tretinoin Side Effects and How to Manage Irritation Hydroquinone vs Tranexamic Acid for Melasma Hydroquinone vs Retinol for Dark Spots: Prescription vs Over the Counter BPC-157 for Skin Rejuvenation and Scar Remodeling: What the 2024-26 Research Really Shows Does Tretinoin Help Acne Scars? What It Can and Cannot Fix

Rx.com prescription skin care is coming soon

Confidential online visits with U.S.-licensed providers, and treatment shipped to your door if it is right for you.

Coming soon

Prescription required. Medications are prescribed only when clinically appropriate after an evaluation by a licensed independent provider. Compounded medications are prepared by a licensed pharmacy for an individual patient and are not FDA-approved; the FDA has not evaluated them for safety, effectiveness or quality. Off-label means a medication is prescribed for a use not on its FDA label. Individual results vary.

Medical services: All clinical evaluations, treatment planning and prescribing decisions are made by licensed independent medical providers. Rx.com provides the technology platform, does not employ healthcare providers and does not practice medicine.

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