Prescription Skin Care, From Home
Dermatology's most proven ingredients for acne, fine lines, melasma and dark spots, through a confidential online visit with a U.S.-licensed provider, with the visit and shipping included.
- Tretinoin for acne and aging
- Hydroquinone blends for dark spots
- Provider-reviewed, prescription only
- Shipped to your door
Compounded, not FDA-approved
Rx.com Tretinoin Cream
Tretinoin + niacinamide + hyaluronic acid · 90-day supply
Tretinoin 0.03%, 0.06% or 0.089% with niacinamide 4% and hyaluronic acid 0.5%, for fine lines, texture and acne. Your provider chooses the strength.
Choose yours to start:
Gentle startTretinoin 0.03% StandardTretinoin 0.06% Experienced retinoid usersTretinoin 0.089%Your provider makes the final choice and may change it. Billed only if prescribed.
Compounded, not FDA-approved
Rx.com Hydroquinone Creams
3 formulas · 90-day supply
Three prescription fade creams (hydroquinone 6%, 8% or 12%, with vitamin C, niacinamide, tretinoin or a mild steroid) for melasma and dark spots.
Choose yours to start:
Gentle, retinoid-freeHydroquinone 6% Dark spots + textureHydroquinone 8% + tretinoin Stubborn melasmaHydroquinone 12% + tretinoinYour provider makes the final choice and may change it. Billed only if prescribed.
Already have a prescription? Compare free coupon prices for tretinoin or hydroquinone.
Shop by concern
What do you want to treat?
AcneBreakouts, clogged pores, blackheads and whiteheads.
Tretinoin cream $39.67/mo ($119 for 3 months)
Start your online visit How tretinoin cream works →
Fine lines & textureFine lines, rough texture and dull, uneven skin.
Tretinoin cream $39.67/mo ($119 for 3 months)
Start your online visit How tretinoin cream works →
Dark spots & melasmaMelasma, sun spots and dark marks left after acne.
Hydroquinone creams $39.67/mo ($119 for 3 months)
Start your online visit How hydroquinone creams works →What you pay, all in
Many online skin care services advertise a low monthly price, then add a doctor visit fee and keep billing you every month or two until you cancel. Rx.com charges once for three months of cream, and only if a provider prescribes it.
Already have a prescription for a plain generic? A free coupon at your local pharmacy is often cheaper: compare prices for tretinoin or hydroquinone.
Prescription strength, when over-the-counter is not enough
Tretinoin is the retinoid with the deepest evidence for acne and sun-related aging: it keeps pores clear, smooths texture and softens fine lines over months.
Hydroquinone is the classic prescription treatment for melasma and dark spots. Since 2020 it can no longer be sold over the counter in the U.S. Rx.com's compounded creams pair it with vitamin C, niacinamide, tretinoin or a mild steroid. Daily sunscreen is what keeps any result.
How it works
U.S.-licensed providers
Online health intake
A short, confidential questionnaire. No appointment, no waiting room.
Provider review
A U.S.-licensed provider reviews your answers and prescribes only if treatment is right for you.
Delivered to your door
A licensed U.S. pharmacy fills your prescription and ships it to you.
FAQs
Do I need a prescription for tretinoin or hydroquinone?
Which one is right for me?
Can I use them while pregnant?
How much do Rx.com's skin treatments cost?
Articles & Guides
Tazarotene vs Tretinoin: Strength, Irritation and Results
Postpartum Melasma Treatment: When You Can Start Hydroquinone
Hydroquinone vs Retinol for Dark Spots: Prescription vs Over the Counter
Hydroquinone and Ochronosis: Risks and Warning Signs
Can You Use Hydroquinone While Pregnant or Breastfeeding?
What Is Hydroquinone? How It Works on Pigment
Hydroquinone Side Effects: What Is Normal and What Is Not
How Much Hydroquinone Cream Do You Need? Tube Sizes and How Long They Last
Generic Hydroquinone 4% Cream: What Is in the Tube and Where to Fill It
Hydroquinone vs Tranexamic Acid for Melasma
Prescription Cream for Hyperpigmentation: Options and How to Get One
Prescription Dark Spot Treatment: What a Provider Can Prescribe
More skin care guides (57)
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- Does Tretinoin Help Acne Scars? What It Can and Cannot Fix
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- How Much Does Tretinoin Cost? Prices With and Without Insurance
- Can You Buy Tretinoin Over the Counter?
- How to Get a Tretinoin Prescription Online
- Tretinoin 0.025% vs 0.05% vs 0.1%: Which Strength Is Right?
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- Tretinoin Cream vs Gel: Which Is Better for Your Skin?
- Tretinoin for Men: Acne, Aging and Razor Bumps
- Hydroquinone for Post-Inflammatory Hyperpigmentation and Acne Marks
- Retin-A vs Generic Tretinoin: Is There a Difference?
- Kojic Acid vs Hydroquinone: Which Fades Dark Spots Better?
- Hydroquinone for Dark Skin Tones: Benefits and Risks
- Is Hydroquinone Safe? The Bans, the Cancer Questions and the Evidence
- Hydroquinone Cream for Melasma: Which Prescription Formula Fits
- Why Hydroquinone Is Used in Cycles: On-and-Off Treatment Explained
- Hydroquinone and Tretinoin Cream: How Combination Fade Creams Work
- Hydroquinone 4% vs 2%: What Prescription Strength Means
- Hydroquinone Before and After: Realistic Results for Dark Spots and Melasma
- What to Look for in a Hydroquinone Cream for Dark Spots
- Hydroquinone Cream for Dark Spots: Choosing a Prescription Formula
- Compounded Hydroquinone Creams: What Is in a Custom Blend?
- Hydroquinone for Dark Underarms and Inner Thighs
- Hydroquinone With Niacinamide and Vitamin C: Does the Combination Help?
- How to Use Hydroquinone Cream Safely: A Step-by-Step Routine
- Hydroquinone for Freckles: Does It Work and Is It Worth It?
- Melasma Treatment Online: Getting a Prescription From Home
- Can You Still Buy Hydroquinone Over the Counter?
- Hydroquinone vs Tretinoin for Dark Spots: Which to Get
- Hydroquinone Coupon: How to Pay Less for Prescription Hydroquinone
- Is Hydroquinone Banned in Other Countries? The Global Rules Explained
- Hydroquinone vs Vitamin C Serum: Prescription vs Over the Counter
- Does Insurance Cover Hydroquinone? Coverage and Cash Options
- Hydroquinone Alternatives: What to Use If You Cannot Use Hydroquinone
- Buy Hydroquinone Online: How to Get It Legally With a Prescription
- Tri-Luma Alternatives for Melasma: Your Options in 2026
- Hydroquinone 4% Cream: Cost and How to Get a Prescription
- Hydroquinone Prescription Online: What the Visit Looks Like
- Hydroquinone and Tretinoin Cream: Getting the Combination Prescribed
- Hydroquinone for Melasma: How to Use It and What to Expect
- What to Expect on Accutane (Isotretinoin), Month by Month
- Tretinoin vs Retinol: Which One Do You Actually Need?
- How Long Does Tretinoin Take to Work? The Real Timeline
- The Best Anti-Wrinkle Creams For Men: Dermatologist-Backed Picks That Work
Ready to get started?
Confidential online visits with U.S.-licensed providers, and treatment shipped to your door if it is right for you.
Tretinoin cream · $119 Hydroquinone creams · $119Prescription required. Medications are prescribed only when clinically appropriate after an evaluation by a licensed independent provider. Compounded medications are prepared by a licensed pharmacy for an individual patient and are not FDA-approved; the FDA has not evaluated them for safety, effectiveness or quality. Off-label means a medication is prescribed for a use not on its FDA label. Individual results vary.
Medical services: All clinical evaluations, treatment planning and prescribing decisions are made by licensed independent medical providers. Rx.com provides the technology platform, does not employ healthcare providers and does not practice medicine.
