Naproxen Sodium Er
Naproxen Sodium ER 500MG
What is Naproxen Sodium Er?
Naproxen Sodium ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain, inflammation, and fever. It is commonly used for managing symptoms of conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other chronic pain disorders. The extended-release formulation allows for sustained release of the medication over time, providing longer-lasting relief with fewer doses compared to immediate-release forms.Side Effects
- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Naproxen Sodium Er ?
Naproxen Sodium ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain, inflammation, and fever. It is commonly used for managing symptoms of conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other chronic pain disorders. The extended-release formulation allows for sustained release of the medication over time, providing longer-lasting relief with fewer doses compared to immediate-release forms.- Blistering, peeling, red skin rash
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
- Chest pain that may spread, trouble breathing, unusual sweating, fainting
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or something that looks like coffee grounds
- Rapid weight gain, swelling in your hands, ankles, or feet
- Change in how much or how often you urinate, painful or difficult urination
- Unusual bleeding, bruising, or weakness
- Fever, chills, cough, sore throat, body aches
- Vision changes
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats that you are using this medicine, especially if you have surgery or a procedure.
- Call your doctor if symptoms get worse, pain lasts more than 10 days, or fever lasts more than 3 days.
- This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failureStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsKidney problemsHigh blood pressureSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Tell your doctor if you have kidney disease, liver disease, anemia, asthma, bleeding problems, high blood pressure, heart failure, a recent heart attack, or a history of stomach or bowel problems (including ulcers or bleeding). Tell your doctor if you smoke or drink alcohol.
Naproxen Sodium Er Coupons & Prices
Naproxen Sodium ER 500MG
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a naproxen sodium ER coupon? Naproxen sodium extended-release is the once-daily, controlled-release form of the familiar NSAID naproxen, sold under the brand name Naprelan. It is available as a low-cost generic, but the cash price can vary widely from one pharmacy to the next, so it pays to compare before you fill. Enter your ZIP above to see today's price and print a free Rx.com discount coupon accepted at more than 60,000 pharmacies nationwide.
What is naproxen sodium ER and how does it work?
Naproxen sodium ER is an extended/controlled-release form of naproxen, a nonsteroidal anti-inflammatory drug (NSAID). Like other NSAIDs, it works by blocking COX-1 and COX-2, the enzymes your body uses to make prostaglandins, the chemical messengers that drive pain, swelling, and inflammation. The once-daily release design (marketed as Naprelan) spreads the dose out over the day, which is why it is used mainly for ongoing inflammatory arthritis rather than a quick one-time ache.
It is FDA-approved to relieve the signs and symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, and to manage pain and treat primary dysmenorrhea (menstrual cramps). Your provider will aim for the lowest effective dose for the shortest time needed to control your symptoms.
Naproxen sodium ER cost and how to save without insurance
The good news for cash-paying patients is that naproxen sodium ER is available as an FDA-approved generic, so it is generally one of the more affordable prescription NSAIDs. What surprises many people is how much the cash price still swings from pharmacy to pharmacy, even within the same town, because each pharmacy sets its own price. That is exactly why comparing matters.
Rx.com compares real cash prices across more than 60,000 U.S. pharmacies so you can see who is cheapest near you and print a free coupon in seconds, no insurance required. The brand Naprelan also has a manufacturer patient savings program listed on its official site, Naprelanus.com; eligibility and terms vary and it typically applies to the brand rather than the generic, so read the details before you rely on it. To check your options, enter your ZIP above to see today's price.
How naproxen sodium ER compares to other NSAIDs
Naproxen sodium ER is one of several NSAIDs used for arthritis and musculoskeletal pain. The right choice depends on your condition, how often you need to dose, and your personal risk factors, so this is a conversation for you and your provider.
- Naproxen — the standard immediate-release form of the same medicine, often taken twice daily.
- Naprelan — the brand name for this same once-daily controlled-release naproxen sodium.
- Meloxicam — a once-daily NSAID commonly used for osteoarthritis and rheumatoid arthritis.
- Diclofenac — another prescription NSAID available in oral and topical forms.
- Celecoxib — a COX-2 selective NSAID that may be chosen when GI risk is a concern.
- Ibuprofen — a widely used shorter-acting NSAID.
Safety information you should know
Naproxen sodium ER carries two FDA boxed warnings, the agency's strongest. First, NSAIDs can raise the risk of serious and potentially fatal cardiovascular events such as heart attack and stroke; this risk can appear early and increases with longer use, and the drug should not be used for pain right before or after heart bypass (CABG) surgery. Second, NSAIDs can cause serious, sometimes fatal, gastrointestinal bleeding, ulcers, and perforation, which can happen without warning signs and are more likely in older adults.
Other important risks include kidney problems, fluid retention and swelling, high blood pressure, liver injury, allergic reactions, and serious skin reactions. It should be avoided at and after 20 weeks of pregnancy because it can harm the developing baby's kidneys. Use the lowest effective dose for the shortest time. This is general information, not medical advice, so talk with your doctor or pharmacist about whether naproxen sodium ER is right for you.
This Naproxen Sodium Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Naproxen Sodium Er on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.