Etodolac
Etodolac 400MG
What is Etodolac?
Etodolac is used to treat pain and relieve the symptoms associated with osteoarthritis and rheumatoid arthritis. Etodolac is a generic drug. The average Etodolac price is about $60 for a supply of 60 capsules, 400 mg oral capsules. You can use our Rx.com savings offer to get an average Etodolac discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
Warnings
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you it is okay.
- Tell your doctor if you have kidney disease, liver disease, heart disease, high blood pressure, anemia, asthma, bleeding disorder, or a history of stomach or bowel problems (including ulcers, bleeding).
- This medicine may cause the following problems:Increased risk of blood clots, heart failure, heart attack, or strokeStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsHigh blood pressureKidney problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Prescription savings · · · ·
What is Etodolac ?
Etodolac is used to treat pain and relieve the symptoms associated with osteoarthritis and rheumatoid arthritis. Etodolac is a generic drug. The average Etodolac price is about $60 for a supply of 60 capsules, 400 mg oral capsules. You can use our Rx.com savings offer to get an average Etodolac discount of up to 80% off of the retail price at participating pharmacies near you.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Bloody or black, tarry stools, severe stomach pain, vomiting blood or material that looks like coffee grounds
- Change in how much or how often you urinate, bloody or cloudy urine
- Chest pain, trouble breathing, coughing up blood
- Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes
- Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness.
- Numbness or weakness in your arm or leg, or on one side of your body, pain in your calf
- Unusual bleeding, bruising, or weakness
- Sudden or severe headache, problems with vision, speech, or walking
- Unusual bleeding, bruising, or weakness.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Vomiting blood or something that looks like coffee grounds.
- Sudden or severe headache, problems with vision, speech, or walking.
- Rapid weight gain, swelling in your hands, ankles, or feet
- Swelling in your hands, ankles, or feet.
- Skin rash or blisters with fever.
- Yellowing of your skin or the whites of your eyes.
- Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you it is okay.
- Tell your doctor if you have kidney disease, liver disease, heart disease, high blood pressure, anemia, asthma, bleeding disorder, or a history of stomach or bowel problems (including ulcers, bleeding).
- This medicine may cause the following problems:Increased risk of blood clots, heart failure, heart attack, or strokeStomach or bowel problems (including bleeding, ulcers, or perforation)Liver problemsHigh blood pressureKidney problemsSerious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Flu-like symptoms.
- Numbness or weakness in your arm or leg, or on one side of your body.
- Pain in your lower leg (calf).
- Rapid weight gain.
- Shortness of breath, cold sweat, and bluish-colored skin.
- Skin rash or blisters with fever.
- Sudden and severe stomach pain, nausea, vomiting, fever, and lightheadedness.
- Sudden or severe headache, problems with vision, speech, or walking.
- Swelling in your hands, ankles, or feet.
- Unusual bleeding, bruising, or weakness.
- Vomiting blood or something that looks like coffee grounds.
- Yellowing of your skin or the whites of your eyes.
Etodolac Coupons & Prices
Etodolac 400MG
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Use a free etodolac coupon from Rx.com to see what this prescription anti-inflammatory costs near you today. Etodolac is available as a generic, and the brand versions (Lodine and Lodine XL) are no longer marketed in the United States. Even so, cash prices for the same tablet or capsule can differ a lot from one pharmacy to the next, which is why it pays to compare before you fill. Enter your ZIP code above to check today's etodolac price across the 60,000+ pharmacies Rx.com compares, then show the coupon at the counter.
What is etodolac and how does it work?
Etodolac is a prescription nonsteroidal anti-inflammatory drug (NSAID). Chemically it is a pyranocarboxylic acid (acetic acid) derivative, and it works as a nonselective COX inhibitor with relative COX-2 selectivity. By blocking these enzymes, it lowers the production of chemical messengers involved in pain, swelling, and fever.
The FDA-approved uses depend on the form. Immediate-release etodolac tablets (400 mg and 500 mg) and capsules (200 mg and 300 mg) are approved for acute mild-to-moderate pain in adults, and for relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis. Etodolac extended-release tablets (400 mg, 500 mg, and 600 mg) are approved for the signs and symptoms of osteoarthritis and rheumatoid arthritis in adults, and for juvenile rheumatoid arthritis in patients 6 to 16 years of age, dosed once daily based on body weight. The extended-release form is not approved for acute pain. Whatever the form, the label directs using the lowest effective dose for the shortest time that fits your treatment goals. Your prescriber decides which form and strength is right for you.
What etodolac costs without insurance, and why comparing matters
Etodolac is a generic medicine, and there is no manufacturer savings card for it. If you are paying cash, the price is set by each pharmacy, and those cash prices vary widely between stores, even between two locations of the same chain a few miles apart. A discount coupon price is often lower than a pharmacy's own cash price, but the only way to know what you will actually pay is to check current prices for your exact strength, form, and quantity in your area.
Enter your ZIP above to see today's etodolac price at pharmacies near you. Two things to keep in mind: the immediate-release and extended-release forms are priced separately, and the number of tablets or capsules you are prescribed changes the total. If you have insurance, it is worth comparing your copay against the coupon price. Sometimes the coupon is lower, sometimes it is not, and you can choose whichever is cheaper (just not both on the same fill).
Etodolac compared with other NSAIDs
There is no single "strongest" NSAID, and no NSAID is an opioid. They differ mostly in how long they last, how they are dosed, and how they suit an individual person. Etodolac is dosed more than once a day in its immediate-release form and once daily in its extended-release form. Other common prescription and over-the-counter options include:
- meloxicam and nabumetone - other once-daily or long-acting NSAIDs often used for arthritis
- naproxen and ibuprofen - widely used NSAIDs available in prescription and over-the-counter strengths
- diclofenac, indomethacin, and sulindac - other prescription NSAIDs
- celecoxib - a COX-2 selective NSAID
Switching between NSAIDs is a decision for your prescriber, not something to do on your own. Taking etodolac together with another NSAID (including over-the-counter ibuprofen or naproxen) raises your risk of stomach bleeding without adding benefit. If cost is the reason you are considering a switch, compare prices for each option above using your ZIP code, then talk with your prescriber or pharmacist.
Etodolac safety: what to know before you fill
Etodolac carries a two-part FDA boxed warning. First, NSAIDs raise the risk of serious cardiovascular thrombotic events, including heart attack and stroke, which can be fatal. That risk may appear early in treatment and may increase the longer the drug is used, and etodolac is contraindicated for pain around coronary artery bypass graft (CABG) surgery. Second, NSAIDs raise the risk of serious gastrointestinal bleeding, ulcers, and perforation of the stomach or intestines, which can also be fatal. These GI events can happen at any time, without warning symptoms, and older adults and people with a history of ulcers or GI bleeding are at greater risk.
Etodolac should not be used by anyone allergic to it, or by anyone who has had asthma, hives, or other allergic-type reactions after aspirin or another NSAID (the aspirin triad). The label also advises avoiding it at and after 20 weeks of pregnancy (risk of fetal kidney problems and low amniotic fluid) and at and after 30 weeks (risk of premature closure of the fetal ductus arteriosus). Other labeled risks include high blood pressure, new or worsening heart failure and swelling, kidney injury, high potassium, liver injury, serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, anaphylaxis, anemia, and the masking of fever or inflammation. Tell your prescriber about everything you take, especially blood thinners such as warfarin, antiplatelet drugs, aspirin, other NSAIDs, corticosteroids, SSRIs or SNRIs (all raise bleeding risk), ACE inhibitors, ARBs, beta-blockers, diuretics, lithium, methotrexate, cyclosporine, or pemetrexed. One quirk worth mentioning to your care team: etodolac can cause a false-positive urine bilirubin test. This page is general information, not medical advice - talk with your doctor or pharmacist about your own situation.
This Etodolac information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Etodolac on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.