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Metformin

Metformin

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What is Metformin?

Metformin is one of the most commonly prescribed medications for type 2 diabetes and is often recommended as a first-line treatment to help lower blood sugar levels. It works by reducing glucose production in the liver and improving the body's sensitivity to insulin, making it an effective and affordable option for long-term diabetes management.

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What is Metformin ?

Metformin is one of the most commonly prescribed medications for type 2 diabetes and is often recommended as a first-line treatment to help lower blood sugar levels. It works by reducing glucose production in the liver and improving the body's sensitivity to insulin, making it an effective and affordable option for long-term diabetes management.

  • Confusion, fast heartbeat, increased hunger, shakiness
  • Trouble breathing, slow heartbeat, lightheadedness, dizziness
  • Stomach pain, nausea, vomiting, muscle pain or cramping
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever or chills
  • Unusual tiredness or weakness
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart failure, blood circulation problems, anemia, metabolic acidosis, an adrenal gland or pituitary gland disorder, vitamin B12 deficiency, or had a heart attack. Tell your doctor if you drink alcohol.
  • Too much of this medicine can cause a rare, but serious condition called lactic acidosis.
  • Part of the extended-release tablet may pass in your stool. This is normal.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine before you have surgery, an x-ray, CT scan, or other medical test.
  • This medicine may cause some premenopausal women who do not have regular monthly periods to ovulate. This can increase the chance of pregnancy. If you are a woman of childbearing potential, discuss birth control options with your doctor.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is metformin used for?
Metformin is FDA-approved, together with diet and exercise, to improve blood sugar control in adults and children 10 and older with type 2 diabetes (extended-release forms are for adults). It is the standard first-line medicine for type 2 diabetes. It is also commonly used off-label for conditions such as PCOS and prediabetes, but those uses should be guided by your prescriber.
What are the most common side effects of metformin?
The most common side effects are digestive, including diarrhea, nausea, vomiting, and stomach discomfort, which can affect up to about 30% of people. These often improve over time, with food, or on the extended-release version. Long-term use can lower vitamin B12, so your doctor may check it from time to time. Metformin alone rarely causes low blood sugar.
Can metformin help with weight loss or PCOS?
Metformin is approved to treat type 2 diabetes, not weight loss. It is very commonly used off-label for polycystic ovary syndrome (PCOS), but that is not an FDA-approved use and should only be done under a provider's direction. Talk with your doctor about whether metformin is appropriate for your situation.
What foods and drinks should you avoid while taking metformin?
Excessive alcohol is the main thing to limit, because heavy drinking raises the risk of lactic acidosis, a rare but serious side effect. Beyond that, follow the balanced diet your provider recommends for managing blood sugar. Ask your doctor or pharmacist about your specific eating and drinking habits while on metformin.
Is it safe to take metformin long term?
Metformin has been used long term for many years and is generally well tolerated, but long-term use can lower vitamin B12 levels, so periodic checks may be recommended. Your provider will also monitor your kidney function, since metformin should not be used with severe kidney impairment. Long-term safety depends on your individual health, so stay in regular contact with your care team.
How much does Metformin cost without insurance?
The price of Metformin $25 without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Metformin 500MG?
Common side effects of Metformin 500MG may include: Confusion, fast heartbeat, increased hunger, shakiness, Trouble breathing, slow heartbeat, lightheadedness, dizziness, Stomach pain, nausea, vomiting, muscle pain or cramping, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fever or chills. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Metformin 500MG?
Generic versions may be available for Metformin 500MG. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Metformin 500MG on Rx.com to compare generic and brand prices at pharmacies near you.
Is Metformin available over the counter?
No, metformin is not available over the counter in the United States. It is a prescription-only medication because a healthcare provider should evaluate whether it is appropriate based on your medical history, kidney function, and other medications you may be taking. If you're interested in starting metformin, a licensed provider can determine whether it's a safe and effective treatment option for your individual health needs.

Metformin Coupons & Prices

Metformin

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Metformin Tablet — prescription drug image
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Metformin 500mg (30)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Metformin prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
500mg · Tablet 60 $13.09 $8.32
625mg · Tablet 60 $2,678.37 $678.39
750mg · Tablet 60 $2,240.00 $817.70
850mg · Tablet 60 $24.99 $8.13
1000mg · Tablet 60 $32.83 $7.11

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a metformin coupon? Metformin is the low-cost generic form of Glucophage and the most widely prescribed first-line medicine for type 2 diabetes. Because it is already generic, cash prices are usually inexpensive, but the exact price can vary a lot from one pharmacy to the next. Rx.com compares metformin prices across more than 60,000 pharmacies so you can find today's best price near you. Enter your ZIP above to see the current price and pull up a free coupon you can show at the counter.

What is metformin and how does it work?

Metformin (metformin hydrochloride) is a biguanide antidiabetic medicine. It is FDA-approved, along with diet and exercise, to improve blood sugar control in adults and in children 10 years and older with type 2 diabetes; the extended-release forms are approved for adults. It is considered the first-line treatment for type 2 diabetes. Metformin works mainly by lowering the amount of sugar your liver makes and by helping your body respond better to its own insulin. On its own, it carries a low risk of causing low blood sugar (hypoglycemia).

Metformin was originally sold under brand names such as Glucophage, Glucophage XR, Fortamet, Glumetza, Riomet, and Riomet ER. Most of those brand versions are now discontinued in the US, but generic metformin is widely available in both immediate-release and extended-release forms.

How much does metformin cost without insurance?

Metformin is a generic, so it is usually one of the more affordable prescriptions, even if you are paying cash without insurance. That said, the price is not the same everywhere. The cash price for the exact same tablets can differ widely between two pharmacies in the same town, which is why comparing before you fill matters. A metformin coupon from Rx.com can bring the cash price down below the standard retail price at many pharmacies.

Rx.com checks metformin prices across more than 60,000 pharmacies to surface the lowest price near you. Enter your ZIP above to see today's price and generate a free coupon. Prices update live on this page, so what you see is current for your area.

Metformin alternatives and related diabetes medications

Metformin is often the starting point for type 2 diabetes, and many people take it alone or alongside other medicines. If you are comparing options, the brand equivalent is Glucophage, and the extended-release generic is metformin ER. Other diabetes medicines your provider may consider include the sulfonylureas glipizide and glimepiride, the DPP-4 inhibitor Januvia (and its ingredient sitagliptin), the SGLT2 inhibitor Jardiance, and the GLP-1 medicine Ozempic.

These medicines work in different ways and are not interchangeable. Only your prescriber can decide which is right for you. You can look up any of them on Rx.com to compare pharmacy prices and pull a coupon.

Metformin safety and side effects

The most common side effects of metformin are digestive: diarrhea, nausea, vomiting, and stomach discomfort, reported in up to about 30% of patients. These often ease over time or with the extended-release form and by taking it with food. With long-term use, metformin can lower vitamin B12 levels, so providers may check B12 periodically.

Metformin carries a boxed warning for a rare but serious condition called lactic acidosis, a buildup of lactic acid in the blood. Warning signs can be subtle, such as feeling generally unwell, muscle aches, trouble breathing, unusual sleepiness, or stomach pain. Risk is higher with kidney or liver problems, age over 65, heavy alcohol use, and around imaging tests that use iodinated contrast or surgery. Metformin should not be used if you have severe kidney impairment (eGFR below 30), and it is often paused around contrast imaging. This is general information, not medical advice; talk with your doctor or pharmacist about your own health before starting, stopping, or changing metformin.

Sources & accuracy

This Metformin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Metformin on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Metformin — Articles & Guides

16 articles
Can You Drink Alcohol While on Ozempic, Wegovy, or Zepbound?
Can You Drink Alcohol While on Ozempic, Wegovy, or Zepbound?
Taking a weekly GLP-1 shot and planning a night out? This guide explains how alcohol interacts with Ozempic, Wegovy, and Zepbound, why the combo can worsen nausea and trigger low blood sugar, and exactly how to sip more safely - or when to pass altogether.
How to Break a Weight-Loss Plateau on Compounded Semaglutide
How to Break a Weight-Loss Plateau on Compounded Semaglutide
A year into compounded semaglutide and the scale won’t budge? This expert guide explains why plateaus happen, how dose titration, macro tweaks, and strength training reignite fat loss, and the red-flag symptoms that mean it’s time to call your provider.
How long does tirzepatide take to work?
How long does tirzepatide take to work?
Tirzepatide is the first dual GIP/GLP-1 medicine approved for type 2 diabetes and obesity, but how quickly will you notice lower blood sugar or weight loss? Get the full timeline, dosing chart, and science-backed tips to help the medication work at its best.
How to Find the Cheapest Tirzepatide Online in 2026
How to Find the Cheapest Tirzepatide Online in 2026
Learn exactly how to track down the cheapest tirzepatide online. From pharmacy price comparisons and free Rx coupons to telehealth membership plans and compounded alternatives, this guide shows seven proven ways to keep more money in your wallet while staying safe.
Buy Semaglutide Online: The Weight-Loss Injection Explained
Buy Semaglutide Online: The Weight-Loss Injection Explained
Looking for an affordable weight-loss shot? This guide shows exactly how to buy semaglutide online for as little as $149 a month through Rx.com, compare prices at U.S. pharmacies, and decide if it’s right for you.
How to Taper Off Semaglutide or Tirzepatide Safely (Without Regaining the Weight)
How to Taper Off Semaglutide or Tirzepatide Safely (Without Regaining the Weight)
Ready to come off your GLP-1? Learn the exact dose-reduction schedule, lab monitoring, and lifestyle moves that keep pounds from rushing back when you stop semaglutide or tirzepatide.
What to Eat on Tirzepatide: Best and Worst Foods for Side Effects and Weight Loss
What to Eat on Tirzepatide: Best and Worst Foods for Side Effects and Weight Loss
Wondering what to eat on tirzepatide? This in-depth guide lists the top foods to help you feel good, minimize gastrointestinal side effects, and hit your weight-loss goals while taking Mounjaro, Zepbound, or compounded tirzepatide.
Metformin Dosage Guide: How Much to Take, When, and Why It Matters
Metformin Dosage Guide: How Much to Take, When, and Why It Matters
Confused about how much metformin to take? This pharmacist-reviewed guide explains the right starting dose, weekly titration schedule, GI side-effect hacks, and when to call your doctor—plus real-world prices and savings tips.
Compounded Tirzepatide Appetite Suppression: How to Eat Enough Protein
Compounded Tirzepatide Appetite Suppression: How to Eat Enough Protein
Compounded tirzepatide can erase hunger so completely that patients forget to eat. This guide explains the science of that appetite switch-off and—more importantly—exactly how to hit your daily protein and calorie targets so you lose fat, not muscle, while keeping side effects low.
Why Tirzepatide Can Feel Like the Flu—and What to Do About It
Why Tirzepatide Can Feel Like the Flu—and What to Do About It
Worried the weekly tirzepatide shot is giving you a never-ending cold? This guide separates typical GLP-1 side effects from true illness and shows proven ways to feel better without derailing weight-loss results.
Constipation on Tirzepatide: How to Get Moving Again
Constipation on Tirzepatide: How to Get Moving Again
Constipation is one of the least-talked-about side effects of tirzepatide. This guide explains why it happens and lays out pharmacist-backed ways to get comfortable again—from magnesium citrate emergencies to daily fiber habits and when to call the doctor.
Tirzepatide Near Me Isn’t Your Only Option: How to Start Treatment Online Today
Tirzepatide Near Me Isn’t Your Only Option: How to Start Treatment Online Today
Wondering where to find tirzepatide without driving all over town? This step-by-step guide shows U.S. adults how to complete a quick telehealth exam, compare prices, and start FDA-approved GLP-1 treatment—all through Rx.com.
Compounded Tirzepatide: How It Works, Legality, Cost, and Safer Alternatives
Compounded Tirzepatide: How It Works, Legality, Cost, and Safer Alternatives
Thinking about compounded tirzepatide for weight loss or diabetes? This guide explains how the compounded version works, whether it’s legal in 2026, typical monthly cost, safety red flags, and smart alternatives if supply rules change.
Is glp1 the same as Ozempic
Is glp1 the same as Ozempic
GLP-1 is a naturally occurring gut hormone, while Ozempic is a brand-name semaglutide injection that mimics GLP-1. Learn how they differ, when each is used, and ways to pay 53–87% less at the pharmacy with Rx.com.
How to Get a Trulicity Prescription Online for Type 2 Diabetes
How to Get a Trulicity Prescription Online for Type 2 Diabetes
Trulicity (dulaglutide) is a once-weekly GLP-1 receptor agonist injection for Type 2 diabetes. Licensed providers can prescribe or refill it through a telehealth visit, with the prescription sent straight to your pharmacy.
How to Get a Toujeo SoloStar Prescription Online
How to Get a Toujeo SoloStar Prescription Online
Toujeo SoloStar is a concentrated long-acting insulin used to manage Type 2 and Type 1 diabetes. Licensed providers can evaluate and prescribe it through telehealth, with the prescription sent directly to your pharmacy.
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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