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Trintellix Tablet — prescription drug image

Trintellix

Trintellix 20MG

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What is Trintellix?

Trintellix is a prescription antidepressant that can cause individuals to feel happier and more energetic. There is not a generic version of Trintellix available at this time. The average cost of Trintellix is $426 for a supply of 30, 10 mg tablets. If you do not have insurance, you can use our Rx.com savings card to get an average discount of 80% off the retail price of your prescription.

Prescription savings · · · ·

What is Trintellix ?

Trintellix is a prescription antidepressant that can cause individuals to feel happier and more energetic. There is not a generic version of Trintellix available at this time. The average cost of Trintellix is $426 for a supply of 30, 10 mg tablets. If you do not have insurance, you can use our Rx.com savings card to get an average discount of 80% off the retail price of your prescription.
  • Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
  • Trouble sleeping, unusual dreams
  • Thoughts of hurting yourself or others, unusual behavior
  • Feeling more excited or energetic than usual
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Confusion, weakness, muscle stiffness or twitching
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding or bruising
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, bleeding problems, glaucoma, or a history of seizures.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause the following problems:Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsSexual problems
  • This medicine may make you dizzy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
What is Trintellix used for?
Trintellix (vortioxetine) is FDA-approved to treat major depressive disorder (MDD) in adults. Its FDA label also cites data on improvement in processing speed and other cognitive symptoms of MDD. It is not approved for use in children. It's sometimes prescribed off-label for anxiety disorders, but that is not an FDA-approved use.
How long does it take for Trintellix to start working?
Like most antidepressants, Trintellix is not fast-acting — it typically takes some weeks of consistent daily use before you or your provider notice a meaningful change, and reaching full effect can take longer still. Don't stop taking it or judge whether it's working without talking to your provider first, since everyone's timeline is a little different.
What are the most common side effects of Trintellix?
Nausea and other digestive symptoms are commonly reported when starting Trintellix, often most noticeable in the first weeks. Sexual side effects are also a known risk. If Trintellix is stopped abruptly, withdrawal-type symptoms such as headache, mood changes, anxiety, nausea, and dizziness can occur. This isn't a complete list of side effects — review the full prescribing information with your provider or pharmacist.
Is there a generic version of Trintellix (vortioxetine)?
No. There is currently no generic version of Trintellix (vortioxetine) available, so it is sold only as the brand-name product.
How much does Trintellix cost with the manufacturer savings card or insurance?
Cost varies by insurance plan and by pharmacy, since Trintellix has no generic equivalent. The manufacturer's official Trintellix savings card program is generally limited to patients with commercial (private) insurance, and its terms can change, so check the manufacturer's site for current details. If you're uninsured, on Medicare, or the manufacturer card doesn't apply, the Rx.com cash coupon is another option — enter your ZIP code above to see today's price near you.
How much does Trintellix cost without insurance?
The price of Trintellix without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Trintellix?
Common side effects of Trintellix may include: Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection, Trouble sleeping, unusual dreams, Thoughts of hurting yourself or others, unusual behavior, Feeling more excited or energetic than usual, Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Trintellix?
Generic versions may be available for Trintellix. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Trintellix on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Trintellix?
The cheapest pharmacy for Trintellix depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Trintellix near you.

Trintellix Coupons & Prices

Trintellix 20MG

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Trintellix Tablet — prescription drug image
Prescription
Trintellix 20mg (5)
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Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Trintellix prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
5mg · Tablet 30 $641.99 $477.05
10mg · Tablet 30 $641.99 $492.98
20mg · Tablet 30 $641.99 $494.07

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

If you're searching for a Trintellix coupon, here's what to know first: Trintellix (vortioxetine) is a brand-name antidepressant with no generic version currently available, so what you pay can vary a lot from one pharmacy to the next. Enter your ZIP code above to see today's Trintellix price at pharmacies near you, and read on for how the manufacturer's savings program compares to the Rx.com cash coupon.

What Is Trintellix and How Does It Work?

Trintellix is the brand name for vortioxetine, a prescription medication classed as a serotonin modulator — sometimes described as a "multimodal" antidepressant because of how it affects serotonin activity. It's FDA-approved for treating major depressive disorder (MDD) in adults, and its FDA label also references data on improvement in processing speed and other cognitive symptoms that can accompany depression. Trintellix is not approved for use in children.

Some providers prescribe Trintellix off-label for anxiety disorders, but that is not an FDA-approved use of this medication — it's a decision to make with your provider, not something to seek out on your own.

Trintellix Coupon: Manufacturer Savings Card vs. the Rx.com Cash Price

Trintellix's manufacturer offers an official savings card program through the Trintellix website. These manufacturer savings cards are generally available only to patients with commercial (private) insurance — they typically don't apply if you're uninsured or on Medicare or Medicaid — and the exact terms, eligibility rules, and how much they reduce your out-of-pocket cost can change, so confirm the current details directly on the manufacturer's site before you count on it.

The Rx.com cash coupon works differently: it's not tied to your insurance status at all, which makes it a useful option if you're uninsured, on Medicare, or if the manufacturer card is declined or doesn't apply to your plan. Because Trintellix does not currently have a generic equivalent, pricing reflects brand-name vortioxetine at whichever pharmacy you use — prices vary by location, so it's worth comparing. Enter your ZIP code above to see today's price near you.

Trintellix vs. Other Antidepressants

Trintellix is one of several antidepressant options a provider might consider for major depressive disorder. Others in common use include sertraline, escitalopram, bupropion, venlafaxine, duloxetine, and trazodone — each works somewhat differently and has its own side-effect profile, and unlike Trintellix, these all have generic versions on the market.

Which antidepressant is right for a given person depends on individual response, other health conditions, and past experience with medications. Don't switch antidepressants on your own — work with your provider, since stopping or changing an antidepressant needs to be managed carefully.

Trintellix Safety Information

Trintellix carries an FDA boxed warning for increased risk of suicidal thinking and behavior in children, adolescents, and young adults up to age 24, particularly when starting treatment or after a dose change. Anyone taking Trintellix, or a family member/caregiver, should watch closely for new or worsening mood changes, especially early in treatment.

  • Serotonin syndrome risk, especially when combined with other serotonergic medications
  • Increased risk of abnormal bleeding or bruising
  • Possible activation of mania or hypomania in people with bipolar disorder
  • Angle-closure glaucoma and low blood sodium (hyponatremia) have been reported
  • Sexual side effects
  • Withdrawal-type symptoms — headache, mood changes, anxiety, nausea, dizziness — if the medication is stopped abruptly

Trintellix is not a controlled substance. This is general information, not medical advice — talk with your provider or pharmacist about your specific situation before starting or stopping Trintellix.

Sources & accuracy

This Trintellix information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Trintellix on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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