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Sertraline Hcl

Sertraline HCl 100MG

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What is Sertraline Hcl?

Sertraline HCl (Zolof) is a prescription antidepressant commonly used to treat depression, anxiety, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and other mental health conditions. Best known under the brand name Zoloft, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). Learn about Sertraline uses, dosage, side effects, effectiveness, and treatment options for anxiety and depression.

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What is Sertraline Hcl ?

Sertraline HCl (Zolof) is a prescription antidepressant commonly used to treat depression, anxiety, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and other mental health conditions. Best known under the brand name Zoloft, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). Learn about Sertraline uses, dosage, side effects, effectiveness, and treatment options for anxiety and depression.

  • Thoughts of hurting yourself or others, unusual mood or behavior
  • Feeling more excited or energetic than usual
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Blistering, peeling, or red skin rash
  • Confusion, weakness, and muscle twitching
  • Eye pain, vision changes, seeing halos around lights
  • Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
  • Unusual bleeding or bruising
  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, bleeding problems, glaucoma, heart disease, heart rhythm problems, or a history of mania, seizure disorder, or stroke.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongation, torsades de pointesSexual problems
  • Tell your doctor if you are sensitive to latex, because the oral liquid comes with a latex rubber dropper.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is sertraline (Zoloft) used for?
Sertraline, sold under the brand name Zoloft, is an SSRI antidepressant. It is FDA-approved to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD). Your provider will determine whether it is appropriate for your condition.
How long does sertraline take to start working?
Some people notice improvements in sleep, energy, or appetite within the first week or two, but the full mood-lifting effect of sertraline often takes several weeks. It is important to keep taking it as prescribed and to talk with your provider before making any changes, even if you do not feel a difference right away.
What are the most common side effects of sertraline?
Common side effects can include nausea, diarrhea, trouble sleeping, drowsiness, dry mouth, and sexual side effects. Many side effects ease over time. Contact your provider if side effects are bothersome or do not go away, and seek help right away for any worsening mood or thoughts of self-harm.
Is it safe to stop taking sertraline suddenly?
No. Stopping sertraline abruptly can cause discontinuation symptoms such as dizziness, irritability, flu-like feelings, and mood changes. If you and your provider decide to stop the medicine, they will usually have you taper the dose gradually. Always talk to your provider before stopping.
Is sertraline the same as Zoloft?
Yes. Sertraline is the generic name and Zoloft is the brand name for the same medicine, sertraline hydrochloride. The generic and brand contain the same active ingredient. Generic sertraline is typically much less expensive than brand-name Zoloft.
How much does Sertraline HCl cost without insurance?
The price of Sertraline HCl without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you. Many people save 60–90% off retail prices with a free Rx.com coupon.
What are the common side effects of Sertraline HCl?
Common side effects of Sertraline HCl may include: Thoughts of hurting yourself or others, unusual mood or behavior, Feeling more excited or energetic than usual, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there, Blistering, peeling, or red skin rash. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Sertraline HCl?
Generic versions may be available for Sertraline HCl. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Sertraline HCl 100MG on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Sertraline HCl?
The cheapest pharmacy for Sertraline HCl depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Sertraline HCl 100MG near you.

Sertraline Hcl Coupons & Prices

Sertraline HCl 100MG

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Sertraline Hcl prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
25mg · Tablet 30 $29.99 $9.00
50mg · Tablet 30 $36.99 $11.72
100mg · Tablet 30 $9.00

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a sertraline HCl coupon? Sertraline hydrochloride is the generic form of Zoloft, a widely prescribed SSRI antidepressant. Because it is available as a generic, it is already one of the more affordable prescription antidepressants, but the cash price can still vary a lot from one pharmacy to the next. Rx.com compares live prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see current pricing and use your free Rx.com discount at the pharmacy.

What is sertraline (Zoloft) and how does it work?

Sertraline hydrochloride is the active ingredient in the brand-name drug Zoloft. It belongs to a class of medicines called selective serotonin reuptake inhibitors, or SSRIs. SSRIs work by increasing the amount of serotonin, a natural chemical messenger, available in the brain, which can help improve mood, sleep, appetite, and energy over time.

Sertraline is FDA-approved to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (with or without agoraphobia), post-traumatic stress disorder (PTSD), social anxiety disorder (social phobia), and premenstrual dysphoric disorder (PMDD). Your provider decides which condition it is right for and what dose to use.

How much does sertraline cost without insurance?

Sertraline is available as a low-cost generic, so it is generally much cheaper than the brand-name version. Even so, the cash price without insurance can differ widely between pharmacies in the same town, which is exactly why comparing prices matters. A pharmacy a few miles away may charge a very different amount for the same tablets.

Rx.com compares live cash prices across more than 60,000 U.S. pharmacies and shows you a free discount you can use at the counter, with or without insurance. Enter your ZIP above to see today's price near you. If you have been prescribed brand-name Zoloft specifically, the manufacturer offers a savings program at zoloft.com/en/savings; eligibility and terms vary, so check the official page for details.

Sertraline vs. other antidepressants

Sertraline is one of several SSRIs and related antidepressants your provider might consider. Others in the same or a related class include escitalopram, fluoxetine, citalopram, and paroxetine. All are available as generics, and each has its own dosing, side-effect profile, and drug interactions.

There is no single "best" antidepressant for everyone. The right choice depends on your diagnosis, your medical history, other medicines you take, and how you respond. Only your prescriber can decide which medicine and dose fit you. If you want to compare prices, you can look up each option on Rx.com and enter your ZIP to see current pharmacy pricing.

Sertraline safety and side effects

Sertraline carries a boxed warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults under 25, especially when starting the medicine or changing the dose. Anyone taking it should be watched closely for worsening mood or unusual changes in behavior during that time. Sertraline should never be taken with MAOI antidepressants, which are contraindicated, and combining it with other serotonin-affecting drugs can raise the risk of a serious reaction called serotonin syndrome.

Other things to be aware of include a higher chance of bleeding (particularly with NSAIDs or blood thinners), low sodium levels (hyponatremia), triggering of mania or hypomania in people with bipolar disorder, QT prolongation, angle-closure glaucoma, and sexual side effects. Do not stop sertraline suddenly, as this can cause discontinuation symptoms; your provider can guide you on tapering. This information is a summary, not medical advice, so talk with your doctor or pharmacist about your specific situation.

Sources & accuracy

This Sertraline Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Sertraline Hcl on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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