Sertraline Hcl
Sertraline HCl 100MG
What is Sertraline Hcl?
Sertraline HCl (Zolof) is a prescription antidepressant commonly used to treat depression, anxiety, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and other mental health conditions. Best known under the brand name Zoloft, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). Learn about Sertraline uses, dosage, side effects, effectiveness, and treatment options for anxiety and depression.
Side Effects
- Thoughts of hurting yourself or others, unusual mood or behavior
- Feeling more excited or energetic than usual
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, bleeding problems, glaucoma, heart disease, heart rhythm problems, or a history of mania, seizure disorder, or stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongation, torsades de pointesSexual problems
- Tell your doctor if you are sensitive to latex, because the oral liquid comes with a latex rubber dropper.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
Prescription savings · · · ·
What is Sertraline Hcl ?
Sertraline HCl (Zolof) is a prescription antidepressant commonly used to treat depression, anxiety, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and other mental health conditions. Best known under the brand name Zoloft, Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). Learn about Sertraline uses, dosage, side effects, effectiveness, and treatment options for anxiety and depression.
- Thoughts of hurting yourself or others, unusual mood or behavior
- Feeling more excited or energetic than usual
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Blistering, peeling, or red skin rash
- Confusion, weakness, and muscle twitching
- Eye pain, vision changes, seeing halos around lights
- Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
- Unusual bleeding or bruising
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, bleeding problems, glaucoma, heart disease, heart rhythm problems, or a history of mania, seizure disorder, or stroke.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems: Serotonin syndrome (may be life-threatening when used with certain other medicines)Increased risk of bleeding problemsHeart rhythm problems, including QT prolongation, torsades de pointesSexual problems
- Tell your doctor if you are sensitive to latex, because the oral liquid comes with a latex rubber dropper.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Sertraline Hcl Coupons & Prices
Sertraline HCl 100MG
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Sertraline Hcl prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 25mg · Tablet | 30 | $29.99 | $9.00 |
| 50mg · Tablet | 30 | $36.99 | $11.72 |
| 100mg · Tablet | 30 | — | $9.00 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a sertraline HCl coupon? Sertraline hydrochloride is the generic form of Zoloft, a widely prescribed SSRI antidepressant. Because it is available as a generic, it is already one of the more affordable prescription antidepressants, but the cash price can still vary a lot from one pharmacy to the next. Rx.com compares live prices across more than 60,000 pharmacies so you can find today's lowest price near you. Enter your ZIP above to see current pricing and use your free Rx.com discount at the pharmacy.
What is sertraline (Zoloft) and how does it work?
Sertraline hydrochloride is the active ingredient in the brand-name drug Zoloft. It belongs to a class of medicines called selective serotonin reuptake inhibitors, or SSRIs. SSRIs work by increasing the amount of serotonin, a natural chemical messenger, available in the brain, which can help improve mood, sleep, appetite, and energy over time.
Sertraline is FDA-approved to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (with or without agoraphobia), post-traumatic stress disorder (PTSD), social anxiety disorder (social phobia), and premenstrual dysphoric disorder (PMDD). Your provider decides which condition it is right for and what dose to use.
How much does sertraline cost without insurance?
Sertraline is available as a low-cost generic, so it is generally much cheaper than the brand-name version. Even so, the cash price without insurance can differ widely between pharmacies in the same town, which is exactly why comparing prices matters. A pharmacy a few miles away may charge a very different amount for the same tablets.
Rx.com compares live cash prices across more than 60,000 U.S. pharmacies and shows you a free discount you can use at the counter, with or without insurance. Enter your ZIP above to see today's price near you. If you have been prescribed brand-name Zoloft specifically, the manufacturer offers a savings program at zoloft.com/en/savings; eligibility and terms vary, so check the official page for details.
Sertraline vs. other antidepressants
Sertraline is one of several SSRIs and related antidepressants your provider might consider. Others in the same or a related class include escitalopram, fluoxetine, citalopram, and paroxetine. All are available as generics, and each has its own dosing, side-effect profile, and drug interactions.
There is no single "best" antidepressant for everyone. The right choice depends on your diagnosis, your medical history, other medicines you take, and how you respond. Only your prescriber can decide which medicine and dose fit you. If you want to compare prices, you can look up each option on Rx.com and enter your ZIP to see current pharmacy pricing.
Sertraline safety and side effects
Sertraline carries a boxed warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults under 25, especially when starting the medicine or changing the dose. Anyone taking it should be watched closely for worsening mood or unusual changes in behavior during that time. Sertraline should never be taken with MAOI antidepressants, which are contraindicated, and combining it with other serotonin-affecting drugs can raise the risk of a serious reaction called serotonin syndrome.
Other things to be aware of include a higher chance of bleeding (particularly with NSAIDs or blood thinners), low sodium levels (hyponatremia), triggering of mania or hypomania in people with bipolar disorder, QT prolongation, angle-closure glaucoma, and sexual side effects. Do not stop sertraline suddenly, as this can cause discontinuation symptoms; your provider can guide you on tapering. This information is a summary, not medical advice, so talk with your doctor or pharmacist about your specific situation.
This Sertraline Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Sertraline Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Sertraline Hcl — Articles & Guides
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.