Duloxetine Hcl
DULoxetine HCl 60MG
What is Duloxetine Hcl?
Cymbalta is used to treat depression, anxiety and other conditions prescribed by your doctor. The generic version of Cymbalta is Duloxetine. On average Cymbalta is priced at about $284 for a supply of 30, 60 mg delayed-release capsules. You can use our Rx.com savings offer to get an average Cymbalta discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Feeling more energetic than usual
- Decrease in how much or how often you urinate
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Warnings
- Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping
- Unusual bleeding or bruising
- Lightheadedness, dizziness, or fainting
- Restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there
- This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.
Prescription savings · · · ·
What is Duloxetine Hcl ?
Cymbalta is used to treat depression, anxiety and other conditions prescribed by your doctor. The generic version of Cymbalta is Duloxetine. On average Cymbalta is priced at about $284 for a supply of 30, 60 mg delayed-release capsules. You can use our Rx.com savings offer to get an average Cymbalta discount of up to 80% off of the retail price at participating pharmacies near you.- Feeling more energetic than usual
- Decrease in how much or how often you urinate
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping
- Eye pain, vision changes, seeing halos around lights
- Confusion, weakness, muscle twitching
- Decrease in sexual ability, desire, drive, or performance
- Unusual bleeding or bruising
- Anxiety, restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Lightheadedness, dizziness, fainting
- Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping
- Unusual bleeding or bruising
- Lightheadedness, dizziness, or fainting
- Restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there
- This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.
- This medicine may cause blurred vision, dizziness, drowsiness, trouble with thinking, or trouble with controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly to avoid falls.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- This medicine may cause the following problems: Serious liver problemsSerotonin syndrome, when used with certain medicinesIncreased risk of bleeding problemsSerious skin reactions, including erythema multiforme, Stevens-Johnson syndromeLow sodium levels in the bloodSexual problems
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, diabetes, digestion problems, glaucoma, heart disease, high or low blood pressure, or problems with urination. Tell your doctor if you smoke or you have a history of seizures, mental health problems (including bipolar disorder, mania), or drug or alcohol addiction.
Duloxetine Hcl Coupons & Prices
DULoxetine HCl 60MG
4 ED medications in one dose
Sildenafil, tadalafil, PT-141 & L-Citrulline · Works in ~15 min · Lasts up to 36 hours
Duloxetine Hcl prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 20mg · Capsule Delayed Release Particles | 90 | $465.99 | $24.35 |
| 30mg · Capsule Delayed Release Particles | 90 | $546.99 | $22.34 |
| 40mg · Capsule Delayed Release Particles | 90 | $465.88 | $88.63 |
| 60mg · Capsule Delayed Release Particles | 90 | $90.00 | $24.98 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a duloxetine HCl coupon? Duloxetine (the generic form of Cymbalta) is already a low-cost generic, but the cash price can vary a lot from one pharmacy to the next, so comparing before you fill is worth it. Rx.com compares duloxetine prices across more than 60,000 U.S. pharmacies and gives you a free discount coupon you can use even without insurance. Enter your ZIP above to see today's price near you.
What is duloxetine HCl and how does it work?
Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant. It works by increasing the levels of two natural chemical messengers in the brain, serotonin and norepinephrine, which help regulate mood and the body's processing of pain signals. It is the active ingredient in the brand-name products Cymbalta, Drizalma Sprinkle, and Irenka.
Duloxetine is FDA-approved to treat major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain such as chronic low back pain and osteoarthritis pain. It is taken as a capsule, usually once daily. Your provider will decide the right dose and use for you.
How much does duloxetine cost without insurance?
Duloxetine is available as a generic, which typically makes it much more affordable than the brand-name versions. Even so, the cash price without insurance is not the same everywhere. Two pharmacies in the same town can charge noticeably different amounts for the identical prescription, which is exactly why comparing pays off.
Rx.com checks live prices at more than 60,000 pharmacies and shows you a free coupon for the lowest option near you. There is no membership fee to use it, and the coupon works whether or not you have insurance. Enter your ZIP above to see today's price and print or show the coupon at the pharmacy counter.
Duloxetine vs. Cymbalta and other alternatives
Duloxetine and Cymbalta are the same medicine. Cymbalta is the original brand name, and duloxetine is the FDA-approved generic, so they contain the identical active ingredient at the same strengths. Choosing the generic is usually the lower-cost path, and you can also compare our duloxetine listing.
Depending on why it is being prescribed, a provider might consider other options. For depression or anxiety, related antidepressants include the SNRI venlafaxine and the SSRI sertraline. For nerve-related pain, alternatives such as pregabalin and gabapentin are sometimes used. Only your provider can decide which medication fits your situation.
Duloxetine safety and side effects
Duloxetine carries a boxed warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults under 24, particularly when starting the drug or changing the dose. Anyone in this group should be watched closely. Other important risks include serotonin syndrome (especially when combined with other serotonergic drugs or MAOIs), liver injury (it should be avoided with heavy alcohol use or chronic liver disease), higher blood pressure, dizziness on standing that can lead to falls, an increased chance of bleeding (especially with NSAIDs, aspirin, or blood thinners), angle-closure glaucoma, and low sodium levels. Do not use duloxetine within 14 days of taking an MAOI.
Do not stop duloxetine suddenly. Stopping abruptly can cause discontinuation symptoms, so any change should be a gradual taper guided by your provider. This information is not medical advice. Talk with your doctor or pharmacist about your full medical history and any other medicines you take before starting or changing duloxetine.
This Duloxetine Hcl information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Duloxetine Hcl on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Duloxetine Hcl — Articles & Guides
2 articles
Browse more medications: starting with D · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.