Trazodone Hcl Coupons & Prices

Use a free Rx.com trazodone HCl coupon to compare cash prices on generic trazodone hydrochloride tablets at more than 60,000 pharmacies near you. Trazodone is an older, widely stocked generic antidepressant, but what one pharmacy charges and what the pharmacy across the street charges can be very different for the exact same prescription. Prices vary by pharmacy, so it is worth comparing. Enter your ZIP code above to see today's price for your strength and quantity, then show the coupon at the counter. There is no membership, no insurance, and no sign-up required.

What is trazodone HCl and how does it work?

Trazodone hydrochloride is an atypical antidepressant known as a SARI, short for serotonin antagonist and reuptake inhibitor. It blocks certain serotonin receptors (5-HT2A and 5-HT2C) while also slowing the reuptake of serotonin in the brain. Trazodone additionally blocks histamine H1 and alpha-1 adrenergic receptors, which is why it is noticeably sedating for most people. It was first approved in the United States in 1981.

The FDA-approved use of trazodone hydrochloride tablets is the treatment of major depressive disorder in adults. It is not approved for children or teenagers. Typical antidepressant dosing starts at 150 mg per day in divided doses, taken shortly after a meal or a snack, and your prescriber adjusts it from there. Trazodone is also very commonly prescribed off label at bedtime for sleep problems; that use is not FDA approved, and only your prescriber can decide whether it is appropriate for you. The old brand names (Desyrel, Desyrel Dividose, and Oleptro extended-release) are all discontinued in the US, so trazodone is now essentially a generic-only medication.

How much does trazodone cost without insurance?

Because there is no marketed brand version of trazodone, there is no manufacturer copay card to look for. What does matter is where you fill it: cash prices for the same trazodone tablet, same strength, same quantity, can vary widely from one pharmacy to the next, because each pharmacy sets its own cash price and its own discount-network rate.

That is what the coupon on this page is for. Enter your ZIP above and Rx.com compares the discounted cash price across more than 60,000 participating pharmacies so you can see who is cheapest near you today. A few things that move the price:

• Strength and quantity. A 30-day supply and a 90-day supply of the same strength can price out very differently per tablet, so ask your prescriber whether a larger fill is appropriate.
• Pharmacy. Big chains, grocery pharmacies, and independents often land at different cash prices for the identical prescription.
• Coupon vs. insurance. The discounted cash price is sometimes lower than a plan copay. You cannot combine a discount coupon with insurance, so ask the pharmacist to run both and use whichever is lower.

Trazodone alternatives and how they compare

Trazodone is one of several older generics used in this space, and they are not interchangeable. Which one fits depends on what is being treated, your other conditions, and your other medications. Never switch or stop an antidepressant on your own.

• Sertraline is an SSRI antidepressant and is generally less sedating than trazodone.
• Mirtazapine is another atypical antidepressant that also tends to be sedating and is often discussed alongside trazodone.
• Amitriptyline and doxepin are older tricyclic-type medicines with their own sedating and anticholinergic effects.
• Zolpidem is a prescription sleep medicine approved for insomnia, and unlike trazodone it is a federally controlled substance.
• Hydroxyzine is an antihistamine used for anxiety and itching that also causes drowsiness.

All of the above are available as generics, and prices vary by pharmacy, so it is worth checking the cash price of each option your prescriber is considering with your ZIP code before you decide where to fill.

Trazodone safety, warnings, and side effects

Trazodone carries an FDA boxed warning for suicidal thoughts and behaviors: antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults in short-term studies. Anyone starting trazodone or changing the dose should be watched closely for worsening mood or new suicidal thoughts. Trazodone is not approved for use in pediatric patients. It must not be taken with an MAO inhibitor, or within 14 days of stopping one, including linezolid and intravenous methylene blue.

Prolonged erection and priapism are a medical emergency. The label warns that trazodone can cause painful and prolonged erections. Priapism is defined on the label as a painful erection lasting more than 6 hours, and if it is not treated promptly it can cause irreversible damage to the erectile tissue. Because of that, the label instructs that any man with an erection lasting more than 4 hours, whether it is painful or not, should immediately stop taking trazodone and seek emergency medical attention. Do not wait to see whether it becomes painful or resolves on its own. Trazodone should be used with caution in men with conditions that may predispose them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia, or with an anatomical deformation of the penis such as Peyronie's disease.

Other important warnings from the label: serotonin syndrome (risk goes up when combined with other serotonergic drugs such as SSRIs, SNRIs, triptans, lithium, tramadol, or St. John's Wort); QT prolongation and a risk of a dangerous heart rhythm called torsades de pointes, so avoid other QT-prolonging drugs and strong CYP3A4 inhibitors such as itraconazole or clarithromycin; low blood pressure on standing, dizziness, and fainting, so rise slowly; more bleeding risk with NSAIDs, aspirin, or blood thinners; angle-closure glaucoma in people with untreated narrow angles; activation of mania or hypomania; and low sodium (hyponatremia/SIADH), especially in older adults. Marked drowsiness is very common, reported in up to about 41% of patients, so do not drive or use machinery until you know how trazodone affects you, and know that alcohol makes the sedation worse. Do not stop trazodone abruptly, since discontinuation symptoms can occur. This page is information, not medical advice; talk with your doctor or pharmacist about your own situation.