Compro Coupons & Prices

Looking for a Compro coupon? Compro is a brand of prochlorperazine 25 mg rectal suppositories (labeler: Padagis US LLC), FDA-approved to control severe nausea and vomiting in adults, and often used when someone cannot keep an oral medicine down. We are not aware of a manufacturer savings card for Compro, so a cash discount coupon is usually the main way to lower the price. Rx.com's free coupon works at most major pharmacies whether you have insurance or not. Enter your ZIP code above to see today's price for Compro or generic prochlorperazine suppositories at pharmacies near you.

What is Compro (prochlorperazine) and how does it work?

Compro is the brand name for prochlorperazine 25 mg rectal suppositories. Prochlorperazine belongs to a group of medicines called phenothiazines. It is both an antipsychotic and an antiemetic (anti-nausea) medicine, and it works mainly by blocking dopamine D2 receptors in the part of the brain that triggers vomiting. Because the suppository is placed in the rectum, it does not have to be swallowed or kept down, which is why doctors and emergency rooms often reach for it when vomiting is severe.

Approved uses depend on the dosage form, so they are not interchangeable. The suppository form, which is what a Compro prescription fills, is approved only for the control of severe nausea and vomiting in adults, with a usual rectal dose of 25 mg twice a day. The prochlorperazine injection is approved to control severe nausea and vomiting and to treat schizophrenia. Only the oral tablet form also carries a short-term generalized non-psychotic anxiety indication, and the tablet label cautions that prochlorperazine is not the first drug to be used for most patients with non-psychotic anxiety (because risks it carries are not shared by common alternatives such as benzodiazepines) and that for anxiety it should not be given at more than 20 mg a day or for longer than 12 weeks, because higher doses or longer use may cause persistent, possibly irreversible tardive dyskinesia. Your prescriber decides which form and dose fit your situation. This page is general information, not medical advice.

Compro cost: manufacturer savings card vs. Rx.com cash coupon

Many brand-name drugs have a manufacturer copay savings card, and those cards are generally limited to people with commercial (job-based or marketplace) insurance, with terms that vary and change over time. As of July 2026, we are not aware of a manufacturer savings card or copay program for Compro, and we are not aware of a patient assistance program for it. (Programs can be added or changed at any time, so it is worth checking with the manufacturer and your pharmacist.) That leaves two realistic paths to a lower price: your insurance benefit, or a cash discount coupon. When you use a cash coupon, you are paying the discounted cash price instead of running the claim through insurance.

It is also worth asking about the generic. Prochlorperazine 25 mg rectal suppositories are available as an FDA-approved generic, and asking your prescriber and pharmacist whether the generic is appropriate for you is a reasonable first step. Prices for both the brand and the generic vary a lot by pharmacy and change over time, so compare before you fill rather than assuming one is cheaper. An Rx.com cash coupon is free to use and is designed for people who are uninsured, on Medicare (where manufacturer cards cannot be used), have a high deductible, or find the medicine is not covered. Show the coupon at the counter before you pay, and compare it against your copay, since sometimes one is lower than the other. Enter your ZIP above to see today's price at pharmacies near you.

Compro vs. other anti-nausea medicines

Compro is one of several prescription options for nausea and vomiting, and they are not interchangeable. Your prescriber picks based on the cause of the nausea, your other conditions, and your other medicines.

• Prochlorperazine - the generic of Compro. Same active ingredient and same 25 mg suppository strength. Prochlorperazine also comes as oral tablets and an injection, which carry different approved uses. Prices vary by pharmacy, so compare the brand and the generic before you fill.
• Promethazine - another phenothiazine used for nausea and vomiting, also available as a rectal suppository. It tends to be more sedating.
• Ondansetron - a different class (a 5-HT3 blocker). It is FDA-approved to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery, and it is sometimes used off-label for stomach viruses. It comes as a tablet and an orally disintegrating tablet, which some people can keep down.
• Metoclopramide - works on the stomach and the brain's vomiting center. It carries its own boxed warning about tardive dyskinesia.

People often ask about Compazine, the old brand of prochlorperazine. Compazine is no longer marketed in the US, but the same medicine is still available as generic prochlorperazine and as the Compro brand suppository.

Safety information you should know

Compro carries a BOXED WARNING: older adults with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death (about 1.6 to 1.7 times higher than with placebo). Compro is not approved to treat dementia-related psychosis. Compro should not be used in people who are comatose, in people taking large amounts of CNS depressants (alcohol, barbiturates, opioids), in pediatric surgery, or in children under 2 years of age or under 20 pounds.

Other important risks include extrapyramidal symptoms (muscle spasms, restlessness, parkinsonism-like stiffness); tardive dyskinesia, an involuntary movement disorder that may be permanent and becomes more likely the longer you take the drug; neuroleptic malignant syndrome (high fever, muscle rigidity, confusion, unstable blood pressure or heart rate - get emergency help); drowsiness and slowed reaction time (do not drive until you know how it affects you); dizziness on standing; a lowered seizure threshold; anticholinergic effects such as dry mouth, constipation, blurred vision, and trouble urinating; sun sensitivity; blood and liver problems; and possible QT prolongation. Prochlorperazine can also mask the signs of an overdose or of an undiagnosed problem such as Reye's syndrome, a bowel obstruction, or a brain tumor. Older adults are more prone to confusion, tremor, and falls. Avoid use near the end of pregnancy unless your clinician says it is clearly needed. For the rectal route specifically, check with a clinician first if you have had recent rectal surgery, rectal bleeding, or severe hemorrhoids. This is a summary, not a complete list - read the label and talk with your doctor or pharmacist.