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Glipizide Er Tablet — prescription drug image

Glipizide Er

glipiZIDE ER 10MG

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What is Glipizide Er?

Glipizide Er is a generic drug used to treat patients with type 2 diabetes. The average Glipizide Er price is about $229 for a supply of 60, 10 mg oral tablets, extended release. You can use our Rx.com savings offer to get an average Glipizide Er discount of up to 80% at participating pharmacies near you.

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What is Glipizide Er ?

Glipizide Er is a generic drug used to treat patients with type 2 diabetes. The average Glipizide Er price is about $229 for a supply of 60, 10 mg oral tablets, extended release. You can use our Rx.com savings offer to get an average Glipizide Er discount of up to 80% at participating pharmacies near you.
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fast or pounding heartbeat, lightheadedness, dizziness
  • Blurred vision, changes in vision
  • Headache or confusion
  • Sweating, trembling, shakiness, increased hunger
  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel problems, stomach or bowel problems, adrenal or pituitary gland problems, or G6PD deficiency. Tell your doctor if you drink alcohol.
  • This medicine may cause the following problems:Higher risk of heart or blood vessel problemsLow blood sugar
  • Part of the extended-release tablet may pass in your stool. This is normal.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
What is glipizide ER used for?
Glipizide ER (extended-release) is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is not used for type 1 diabetes or diabetic ketoacidosis. It belongs to the sulfonylurea class and works by helping the pancreas release more insulin.
What is the difference between glipizide and glipizide ER (extended-release)?
They are the same active drug, but the ER version releases the medicine slowly over the day, so it is usually taken once daily. Immediate-release glipizide is typically taken before meals, sometimes more than once a day. The ER tablet also has a shell that stays intact and can appear in your stool. Your prescriber decides which form fits your needs.
Should glipizide ER be taken in the morning or at night?
Glipizide ER is a once-daily tablet. Follow the exact timing your doctor or pharmacist gives you and try to take it at the same time each day, typically with a meal. Because it can lower blood sugar, taking it and eating on a consistent schedule helps reduce the risk of low blood sugar. Do not change your timing without asking your provider.
Does glipizide ER cause low blood sugar or weight gain?
Both are possible. The main risk with glipizide ER is hypoglycemia (low blood sugar), which is more likely if you skip meals, drink alcohol, or have kidney or liver problems, and in older adults. Severe low blood sugar can cause confusion, seizures, or loss of consciousness. Sulfonylureas like glipizide can also cause some weight gain. Ask your provider how to recognize and treat low blood sugar.
Can glipizide ER tablets be cut or crushed?
No. Glipizide ER tablets should be swallowed whole and not crushed, split, or chewed, because doing so can release the drug too quickly. The tablet has a non-absorbable shell that slowly releases the medicine; it is normal to sometimes see the empty shell in your stool.
How much does Glipizide Er cost without insurance?
The price of Glipizide Er without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Glipizide Er?
Common side effects of Glipizide Er may include: Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Fast or pounding heartbeat, lightheadedness, dizziness, Blurred vision, changes in vision, Headache or confusion, Sweating, trembling, shakiness, increased hunger. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Glipizide Er?
Generic versions may be available for Glipizide Er. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Glipizide Er on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Glipizide Er?
The cheapest pharmacy for Glipizide Er depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Glipizide Er near you.

Glipizide Er Coupons & Prices

glipiZIDE ER 10MG

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Glipizide Er Tablet — prescription drug image
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Glipizide Er prices by dosage

Lowest cash price with a free Rx.com coupon vs. the average retail price.

Dosage Quantity Retail price Rx.com price
2.5mg · Tablet 90 $50.30 $22.02
5mg · Tablet 90 $46.39 $39.33
10mg · Tablet 90 $59.99 $23.65

Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.

Looking for a glipizide ER coupon? Glipizide extended-release is the low-cost generic version of Glucotrol XL, a once-daily sulfonylurea used to help control blood sugar in adults with type 2 diabetes. Because it is a generic, cash prices are already modest, but they can still vary a lot from one pharmacy to the next, so comparing matters. Enter your ZIP above to see today's price on glipizide ER at pharmacies near you. Rx.com compares prices across more than 60,000 pharmacies so you can find the lowest cash price without insurance.

What is glipizide ER and how does it work?

Glipizide extended-release (ER) is an oral medicine in the sulfonylurea class, sold under the brand name Glucotrol XL. It is approved as an addition to diet and exercise to improve glycemic control, meaning it helps lower blood sugar, in adults with type 2 diabetes. It is not used for type 1 diabetes or for diabetic ketoacidosis. Sulfonylureas work by helping the pancreas release more insulin.

The "ER" (extended-release) formulation releases the medicine slowly over the day, so it is usually taken just once daily. The tablet has a non-absorbable shell that stays intact as the drug is released; it is normal to sometimes see the empty shell in your stool. Swallow the tablet whole and do not crush or chew it.

Glipizide ER cost and coupons without insurance

Glipizide ER is available as a generic, which is one reason its cash price tends to be low compared with brand-name diabetes drugs. Even so, the price you pay can differ widely depending on which pharmacy you use, so it pays to compare before you fill. There is no manufacturer savings card for this generic; the savings come from finding the best cash price near you.

Rx.com shows live prices and free coupons across more than 60,000 pharmacies. Enter your ZIP above to see today's price on glipizide ER in your area, then bring the coupon to the pharmacy counter. If your prescriber wrote it for the brand, you can also compare Glucotrol XL to see the difference.

Glipizide ER alternatives and related medicines

Glipizide ER is one of several oral options for type 2 diabetes. Which one is right for you is a decision for you and your provider, but it can help to know the common alternatives when comparing prices:

  • Glipizide — the immediate-release form of the same drug, usually taken before meals.
  • Glimepiride and Glyburide — other sulfonylureas that also lower blood sugar by prompting insulin release.
  • Metformin and Metformin ER — a different class often used as a first-line diabetes medicine.

All of these are commonly available as generics. Use the ZIP search above to compare live cash prices on any of them across the pharmacies near you.

Glipizide ER safety and side effects

This is general information, not medical advice, so talk with your doctor or pharmacist about your own situation. The current label for glipizide ER has no boxed warning. The most important risk is hypoglycemia (low blood sugar), which is more likely with missed meals, alcohol use, kidney or liver problems, or in older or debilitated people. Severe low blood sugar can cause confusion, seizures, or loss of consciousness, so it is worth knowing the warning signs. Glipizide can also cause weight gain.

Take the ER tablet whole; do not crush or chew it, and do not be alarmed if the empty tablet shell appears in your stool. Photosensitivity (increased sensitivity to sunlight) can occur. Rare hemolytic anemia has been reported in people with G6PD deficiency, and, as with sulfonylureas generally, a possible increase in cardiovascular mortality has historically been discussed. Use extra caution if you have reduced kidney or liver function or are elderly. Tell your provider about all your other medicines and conditions before starting.

Sources & accuracy

This Glipizide Er information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Glipizide Er on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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