Synjardy Xr
Synjardy XR
What is Synjardy Xr?
Synjardy XR (empagliflozin/metformin extended-release) is a prescription medication used to help improve blood sugar control in adults with type 2 diabetes. It combines two diabetes medications in a once-daily extended-release tablet and, when used alongside diet and exercise, can also help reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
Side Effects
- Fast or trouble breathing, nausea, vomiting, stomach pain, severe weakness, tiredness
- Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, chills
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Warnings
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Low blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsLow blood sugar, when used with other diabetes medicineIncreased risk of genital yeast or urinary tract infections (including pyelonephritis, urosepsis)Increased risk for leg, foot, or toe amputationFournier's gangrene (skin or tissue damage of the area between the anus and genitals)
- Tell your doctor if have kidney disease, liver disease, heart failure, vitamin B12 deficiency, or a history of pancreas problems, urinary tract or genital yeast infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
- Do not breastfeed during treatment with this medicine.
Prescription savings · · · ·
What is Synjardy Xr ?
Synjardy XR (empagliflozin/metformin extended-release) is a prescription medication used to help improve blood sugar control in adults with type 2 diabetes. It combines two diabetes medications in a once-daily extended-release tablet and, when used alongside diet and exercise, can also help reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
- Fast or trouble breathing, nausea, vomiting, stomach pain, severe weakness, tiredness
- Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, chills
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Lightheadedness, dizziness, fainting
- Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness
- Increased hunger, confusion, shaking, trembling, sweating
- Pain, tenderness, sores or ulcers, or infections on the leg or foot
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Low blood pressureKetoacidosis (high ketones and acid in the blood), which can be life-threateningKidney problemsLow blood sugar, when used with other diabetes medicineIncreased risk of genital yeast or urinary tract infections (including pyelonephritis, urosepsis)Increased risk for leg, foot, or toe amputationFournier's gangrene (skin or tissue damage of the area between the anus and genitals)
- Tell your doctor if have kidney disease, liver disease, heart failure, vitamin B12 deficiency, or a history of pancreas problems, urinary tract or genital yeast infections, leg problems (including amputation, blood vessel disease), or foot infection, sores, or ulcers. Tell your doctor if you are on a low-salt diet, if you drink alcohol, or if you are having surgery or other procedures that require fasting.
- Do not breastfeed during treatment with this medicine.
- Tell your doctor if you are pregnant or planning to become pregnant. Do not use this medicine during the second and third part of your pregnancy, unless your doctor tells you to. It could harm an unborn baby. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
Synjardy Xr Coupons & Prices
Synjardy XR
Weight-loss medication, prescribed online
Licensed U.S. providers · No insurance needed · Shipped to your door
Looking for a Synjardy XR coupon? Synjardy XR is a brand-name, once-daily extended-release tablet that combines two type 2 diabetes medicines, empagliflozin and metformin, in one pill. Because it is brand-only with no generic available, the cash price can be high. Enter your ZIP code above to see today's Rx.com price at pharmacies near you, and compare it with the manufacturer's savings card to find the lowest cost for your situation.
What is Synjardy XR and how does it work?
Synjardy XR is a fixed-dose combination tablet that pairs two diabetes medicines with different jobs. Empagliflozin is an SGLT2 inhibitor, which helps the kidneys remove extra sugar from the body through the urine. Metformin is a biguanide, which lowers the amount of sugar your liver makes and helps your body respond better to insulin. The "XR" means extended-release, so the tablet is taken once a day, while the original Synjardy is an immediate-release version taken twice a day.
Synjardy XR is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes when treatment with both empagliflozin and metformin is appropriate. Through its empagliflozin component, it is also indicated to reduce the risk of cardiovascular death in adults who have type 2 diabetes together with established cardiovascular disease. It is not used for type 1 diabetes or for diabetic ketoacidosis. Your provider decides whether it is right for you.
Synjardy XR cost: manufacturer savings card vs. Rx.com cash coupon
The maker of Synjardy XR, Boehringer Ingelheim, offers a manufacturer savings card that can lower the out-of-pocket cost for eligible patients. These cards are generally limited to people with commercial (private) insurance, and the exact terms and eligibility rules change over time. Check the current details on the official Synjardy savings and support page. If you are uninsured, the card is usually not an option; the manufacturer's site is also where you can look for any patient assistance program for those who qualify.
An Rx.com cash coupon works differently. It is a discount you can use even when the manufacturer card does not apply, such as when you are uninsured, on Medicare, or when the savings card is declined at the pharmacy. You do not use insurance and the coupon together; you pay the discounted cash price shown for that pharmacy. Because Synjardy XR is brand-only with no generic available, prices vary widely between pharmacies, so it is worth comparing. Enter your ZIP above to see today's price near you.
Alternatives and related diabetes medicines
Synjardy XR combines two drugs that are also sold on their own. The empagliflozin piece is available as Jardiance (or as empagliflozin), and the metformin piece is a widely used, low-cost generic, metformin. Depending on your treatment plan, your provider may prescribe these separately instead of the combination pill.
Other combination and single-ingredient options in the same treatment area include Trijardy XR (which adds a third medicine to empagliflozin and metformin), Jentadueto (a different metformin combination), and Farxiga (a different SGLT2 inhibitor). Only your provider can decide which medicine fits your health needs. You can compare cash prices for any of these on Rx.com by entering your ZIP code.
Important safety information
Synjardy XR carries a boxed warning for lactic acidosis, a rare but potentially fatal buildup of acid in the blood linked to the metformin component. The risk goes up with kidney or liver problems, serious infection (sepsis), dehydration, drinking too much alcohol, and around imaging tests that use contrast dye. Get medical help right away if you feel very weak or tired, have unusual muscle pain, trouble breathing, stomach pain with nausea or vomiting, or feel cold or dizzy. Synjardy XR is not for people with an eGFR below 30, metabolic acidosis, or a known allergy to its ingredients.
Other important risks include ketoacidosis (which can happen even when blood sugar looks near normal), low blood pressure or dehydration, sudden kidney problems, serious urinary tract infections, genital yeast infections and a rare serious infection of the perineum (Fournier gangrene), low blood sugar (more likely when taken with insulin or a sulfonylurea), and low vitamin B12 with long-term metformin use. This page is general information, not medical advice. Talk with your doctor or pharmacist about your full health history and all the medicines you take before starting or changing Synjardy XR.
This Synjardy Xr information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Synjardy Xr on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.