Jentadueto
Jentadueto 2.5-1000MG
What is Jentadueto?
Jentadueto is a prescription medication that combines linagliptin and metformin to help improve blood sugar control in adults with type 2 diabetes. By targeting blood sugar through two complementary mechanisms, Jentadueto can help lower A1C while supporting long-term diabetes management alongside a healthy diet and regular exercise.
Side Effects
- Rapid weight gain, swelling in your hands, ankles, or feet
- Fast or trouble breathing, severe weakness, tiredness, or confusion
- Severe joint pain
Warnings
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, adrenal or pituitary gland disease, vitamin B12 deficiency, or a history of alcohol abuse, heart failure, or pancreas problems.
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood, which can be life-threatening)PancreatitisHeart failureLow blood sugar, when used with other diabetes medicines
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
Prescription savings · · · ·
What is Jentadueto ?
Jentadueto is a prescription medication that combines linagliptin and metformin to help improve blood sugar control in adults with type 2 diabetes. By targeting blood sugar through two complementary mechanisms, Jentadueto can help lower A1C while supporting long-term diabetes management alongside a healthy diet and regular exercise.
- Rapid weight gain, swelling in your hands, ankles, or feet
- Fast or trouble breathing, severe weakness, tiredness, or confusion
- Severe joint pain
- Sudden and severe stomach pain, nausea, vomiting, fever
- Trouble breathing, cold sweat, bluish-colored skin
- Lightheadedness, dizziness, fainting
- Increased hunger, headache, shaking, trembling, sweating
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, adrenal or pituitary gland disease, vitamin B12 deficiency, or a history of alcohol abuse, heart failure, or pancreas problems.
- This medicine may cause the following problems:Lactic acidosis (too much acid in the blood, which can be life-threatening)PancreatitisHeart failureLow blood sugar, when used with other diabetes medicines
- This medicine may cause some patients to become dehydrated. Drink plenty of water every day, during exercise, or in hot weather.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.
Jentadueto Coupons & Prices
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Jentadueto prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 2.5-1000mg · Tablet | 60 | — | $518.53 |
| 2.5-500mg · Tablet | 60 | $620.99 | $518.53 |
| 2.5-850mg · Tablet | 60 | $620.99 | $518.53 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for a Jentadueto coupon? Jentadueto is a brand-name combination tablet (linagliptin plus metformin) used with diet and exercise to improve blood sugar control in adults with type 2 diabetes. There is no generic version yet, so the price can be high at the pharmacy. Enter your ZIP above to see today's cash price at pharmacies near you and print or show your free Rx.com coupon at the counter, no insurance required.
What is Jentadueto and how does it work?
Jentadueto combines two diabetes medicines in one tablet: linagliptin, a DPP-4 inhibitor, and metformin hydrochloride, a biguanide. Linagliptin helps your body release more insulin after meals and lowers the amount of sugar your liver makes, while metformin reduces sugar production and helps your body respond better to its own insulin. Together they improve glycemic control in adults with type 2 diabetes when treatment with both ingredients is appropriate, such as when metformin alone is not enough, when you are already taking both drugs, or as initial combination therapy.
Jentadueto is taken twice daily. Jentadueto XR is the extended-release form taken once daily. Jentadueto is not used for type 1 diabetes or for diabetic ketoacidosis. Always take it exactly as your provider directs.
Jentadueto cost: manufacturer savings card vs. Rx.com cash coupon
Because there is no generic, Jentadueto can be expensive, and there are two main ways to save. The manufacturer savings card from Boehringer Ingelheim can lower your copay, but these cards are generally limited to people with commercial (private) insurance and typically exclude government plans like Medicare and Medicaid. Terms, eligibility, and any savings limits vary, so check the official page for current details: Jentadueto savings card eligibility.
The Rx.com cash coupon works differently. It is a cash-price discount, not insurance, so it can help if you are uninsured, on Medicare or Medicaid, or if the manufacturer card is declined or you do not qualify for it. You cannot combine a cash coupon with insurance on the same purchase, but you can compare both and use whichever is lower. Enter your ZIP above to see today's Rx.com price near you.
Alternatives and related diabetes medicines
Jentadueto is one of several options for type 2 diabetes, and your provider chooses based on your health history and goals. Related and alternative medicines include:
- Tradjenta — the standalone linagliptin (DPP-4) component, without metformin.
- Metformin — the metformin component alone, which is available as a low-cost generic.
- Janumet — a similar combination of a different DPP-4 inhibitor (sitagliptin) plus metformin.
- Jardiance — empagliflozin, an SGLT2 inhibitor from a different drug class.
- Trijardy XR and Glyxambi — combinations that pair linagliptin and/or empagliflozin for broader coverage.
These are not interchangeable, and switching should only be done with your prescriber. If cost is your concern, ask whether generic metformin plus a separate DPP-4 inhibitor could work for you.
Important safety information
Jentadueto carries a boxed warning for lactic acidosis, a rare but serious build-up of acid in the blood linked to the metformin component. The risk rises with kidney or liver problems, serious infection, dehydration, heavy alcohol use, and acute heart failure. Symptoms can include unusual tiredness, muscle pain, trouble breathing, stomach pain, or feeling cold. Seek emergency care if these occur. Jentadueto should not be used if your kidney function (eGFR) is below 30, if you have acute metabolic acidosis, or if you are allergic to linagliptin, and it may need to be paused before imaging tests that use iodinated contrast dye.
Other possible risks include pancreatitis, heart failure, severe joint pain, a skin condition called bullous pemphigoid, low blood sugar (especially when combined with insulin or a sulfonylurea), and long-term vitamin B12 deficiency. This is general information, not medical advice. Talk with your doctor or pharmacist about your full history and any side effects you notice.
This Jentadueto information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Jentadueto on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.