Droxidopa
Droxidopa 100MG
What is Droxidopa?
Droxidopa is a synthetic amino acid precursor that is metabolized to norepinephrine by dopa-decarboxylase. It is primarily used to treat neurogenic orthostatic hypotension, offering symptomatic relief by increasing blood pressure. Droxidopa is effective in conditions characterized by diminished sympathetic nerve activity leading to poor blood pressure control.Side Effects
- Confusion or fever
- Fast, pounding, or uneven heartbeat
- Swelling in your hands, ankles, or feet
Warnings
- Tell your doctor if you are pregnant or if you have kidney disease, asthma, congestive heart failure, heart or blood vessel problems, heart rhythm problems, or have an allergy to aspirin.
- Do not breastfeed while you are using this medicine.
- This medicine may raise your blood pressure and increase your risk for supine hypertension (high blood pressure when you lie on your back). It is best to elevate the head of your bed, and to rest and sleep with your head elevated. You may also need to monitor your blood pressure at home before, during, and after treatment.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Prescription savings · · · ·
What is Droxidopa ?
Droxidopa is a synthetic amino acid precursor that is metabolized to norepinephrine by dopa-decarboxylase. It is primarily used to treat neurogenic orthostatic hypotension, offering symptomatic relief by increasing blood pressure. Droxidopa is effective in conditions characterized by diminished sympathetic nerve activity leading to poor blood pressure control.- Confusion or fever
- Fast, pounding, or uneven heartbeat
- Swelling in your hands, ankles, or feet
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision, severe headache, trouble breathing
- Tell your doctor if you are pregnant or if you have kidney disease, asthma, congestive heart failure, heart or blood vessel problems, heart rhythm problems, or have an allergy to aspirin.
- Do not breastfeed while you are using this medicine.
- This medicine may raise your blood pressure and increase your risk for supine hypertension (high blood pressure when you lie on your back). It is best to elevate the head of your bed, and to rest and sleep with your head elevated. You may also need to monitor your blood pressure at home before, during, and after treatment.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Droxidopa Coupons & Prices
Droxidopa 100MG
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Droxidopa prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 100mg · Capsule | 90 | $2,746.69 | $79.57 |
| 200mg · Capsule | 90 | $2,581.89 | $144.68 |
| 300mg · Capsule | 90 | $666.87 | $191.84 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Droxidopa is a prescription medicine used to treat symptoms of low blood pressure on standing (neurogenic orthostatic hypotension). Generic droxidopa capsules are now sold by several manufacturers alongside the brand Northera, and prices can vary a lot by pharmacy. Enter your ZIP above to compare a droxidopa coupon and see today's price near you.
What is droxidopa and how does it work?
Droxidopa is a synthetic amino acid precursor that the body converts into norepinephrine, a chemical that helps regulate blood pressure. It's used to treat orthostatic dizziness, lightheadedness, or the feeling of being about to black out in adults with symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure (including Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, or nondiabetic autonomic neuropathy. Effectiveness beyond two weeks of treatment hasn't been established in trials, so doctors periodically reassess whether it's still helping.
Saving on droxidopa
Generic droxidopa capsules are FDA-approved and marketed by multiple manufacturers, and they're generally far less expensive than the brand-name Northera. Because it's a generic, prices can still vary considerably from one pharmacy to the next. Rx.com compares droxidopa pricing across 60,000+ pharmacies so you can find the lowest cash price near you, whether or not you have insurance.
Northera vs. generic droxidopa
Northera is the original brand-name version of droxidopa. Since an FDA-approved generic is now available in the same capsule strengths, asking your pharmacy to fill the generic is usually the simplest way to lower your cost, whether you're paying cash or using insurance.
Safety information
Droxidopa carries an FDA boxed warning for supine hypertension, a rise in blood pressure while lying down, which is common in people with autonomic failure and can increase stroke risk. Your doctor will check your blood pressure lying down and standing before and during treatment, and will typically advise sleeping with the head of the bed raised to reduce this risk. This is general information, not medical advice; talk with your doctor about monitoring your blood pressure while taking droxidopa.
This Droxidopa information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Droxidopa on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
