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Depression

Antidepressant medications used to treat depression and related mood conditions.

What is Depression?

Depression is a serious mood disorder that goes beyond just feeling sad or irritable for a few days. It can affect how you think, feel, and handle everyday activities. Even basic tasks like sleeping, eating, or working may become difficult. It's important to seek help at the earliest sign of depression, as early treatment can help manage symptoms.

Symptoms of Depression

Symptoms of depression can vary from person to person and may not always include sadness. Common symptoms include feeling sad or empty, losing interest in activities you once enjoyed, changes in appetite, sleeping too much or too little, feeling tired, and experiencing feelings of hopelessness or irritability. Some people may also have physical symptoms like aches and pains or thoughts of death or suicide.

Causes and Types of Depression

Depression can be caused by a mix of genetic, biological, environmental, and psychological factors. It can occur at any age and affects anyone, though it is more common in women due to hormonal changes. The most common types of depression include major depression and persistent depressive disorder, with other types like seasonal affective disorder and bipolar disorder also recognized.

Why It Matters If Untreated

If left untreated, depression can significantly impact your daily life and overall well-being. It may worsen existing chronic conditions and lead to more severe mental health issues.

How is Depression Treated?

Treatment for depression often requires a long-term approach. It may include a combination of lifestyle changes, psychotherapy (talk therapy), and a range of prescription medicines. It's important to work with your healthcare provider to find the right treatment plan for you.

When to See a Doctor

If you think you may have depression, it is important to talk to your healthcare provider or a mental health professional. They can help diagnose your condition and recommend appropriate treatment.

Medications used to treat Depression

Several classes of medication treat depression. Which is right depends on your health — that is a decision for you and your provider. Compare prices and coupons on any of them:

Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs work by increasing the level of serotonin in the brain, which can help improve mood and reduce symptoms of depression.

Compare prices: Citalopram Hydrobromide, Escitalopram Oxalate, Sertraline Hcl

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

SNRIs increase the levels of serotonin and norepinephrine, two neurotransmitters that are important for mood regulation.

Compare prices: Duloxetine Hcl, Venlafaxine Hcl, Desvenlafaxine Er

Tricyclic Antidepressants (TCAs)

TCAs work by blocking the reuptake of neurotransmitters like norepinephrine and serotonin, which helps to elevate mood.

Compare prices: Amitriptyline Hcl, Nortriptyline Hcl, Imipramine Hcl

Atypical Antidepressants

Atypical antidepressants work through various mechanisms to help improve mood and alleviate depressive symptoms.

Compare prices: Bupropion Hcl, Mirtazapine, Trazodone Hcl

Monoamine Oxidase Inhibitors (MAOIs)

MAOIs work by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters like serotonin and norepinephrine, thus increasing their levels.

Compare prices: Phenelzine Sulfate, Tranylcypromine Sulfate, Selegiline Hcl

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Frequently asked questions

What are the common symptoms of depression?

Common symptoms include feeling sad or empty, losing interest in favorite activities, changes in appetite, sleeping too much or too little, feeling tired, and experiencing feelings of hopelessness or irritability.

What causes depression?

Depression can be caused by genetic, biological, environmental, and psychological factors. It can occur at any age and affects anyone, but is more common in women.

What types of depression are there?

The most common types of depression are major depression and persistent depressive disorder. Other types include seasonal affective disorder and bipolar disorder.

How is depression diagnosed?

A healthcare provider may use a medical history, physical exam, and mental health evaluation to diagnose depression. Symptoms must occur most of the day, nearly every day, for at least two weeks.

What treatments are available for depression?

Treatment may include lifestyle changes, psychotherapy, and a range of prescription medicines. It often requires a long-term approach.

Compare prices for depression medications

73 medications — select one to compare prices and coupons.

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Condition information adapted from MedlinePlus, U.S. National Library of Medicine.

Medication list sourced from RxClass (MED-RT, U.S. National Library of Medicine). Inclusion does not imply a medication is right for you.

Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.

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