Bupropion Hcl Er (Smoking Det)
buPROPion HCl ER (Smoking Det) 150MG
What is Bupropion Hcl Er (Smoking Det)?
Bupropion HCl ER (Smoking Det) is an extended-release medication specifically formulated to aid in smoking cessation. It works by interfering with the neurological chemicals associated with nicotine addiction, thereby reducing cravings and withdrawal symptoms linked to quitting smoking. This medication is typically used as part of a comprehensive program that includes behavioral support.Side Effects
- Thoughts of hurting yourself, worsening depression, severe agitation or confusion
- Seeing or hearing things that are not there, feeling like people are against you
- Seizures
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, glaucoma, mental illness (including bipolar disorder), or high blood pressure. Tell your doctor if you have a history of drug addiction or if you drink alcohol.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Increased risk of seizuresChanges in mood or behaviorHigh blood pressureSerious skin reactions
Prescription savings · · · ·
What is Bupropion Hcl Er (Smoking Det) ?
Bupropion HCl ER (Smoking Det) is an extended-release medication specifically formulated to aid in smoking cessation. It works by interfering with the neurological chemicals associated with nicotine addiction, thereby reducing cravings and withdrawal symptoms linked to quitting smoking. This medication is typically used as part of a comprehensive program that includes behavioral support.- Thoughts of hurting yourself, worsening depression, severe agitation or confusion
- Seeing or hearing things that are not there, feeling like people are against you
- Seizures
- Sudden increase in energy, racing thoughts, trouble sleeping
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Chest pain, trouble breathing, fast, slow, or uneven heartbeat
- Eye pain, vision changes, seeing halos around lights
- Muscle or joint pain, fever with rash
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, glaucoma, mental illness (including bipolar disorder), or high blood pressure. Tell your doctor if you have a history of drug addiction or if you drink alcohol.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Increased risk of seizuresChanges in mood or behaviorHigh blood pressureSerious skin reactions
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- Zyban® is only part of a complete program to help you quit smoking. You may still want to smoke at times. Have a plan to cope with these situations.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Bupropion Hcl Er (Smoking Det) Coupons & Prices
buPROPion HCl ER (Smoking Det) 150MG
Bupropion HCl extended-release (smoking deterrent) is the generic prescription tablet used specifically to help adults quit smoking. It was originally sold under the brand name Zyban, which is no longer marketed in the US, so the medicine is now available only as a generic. Prices for this generic can vary a lot between pharmacies; enter your ZIP above to compare and find a bupropion smoking-cessation coupon near you.
What is this medicine and how does it work?
This is bupropion hydrochloride in an extended-release tablet, taken twice a day starting about one to two weeks before your quit date, for smoking cessation specifically (not the once-daily bupropion XL tablets prescribed for depression, which are a different product and dosing schedule). It's not a nicotine product; it's believed to help by acting on brain chemicals involved in nicotine cravings and withdrawal. It is not a controlled substance.
Cost without insurance
Because this is a widely manufactured generic, cash prices vary significantly by pharmacy and location. Rx.com compares prices across 60,000+ pharmacies so you can see which one has the lowest price near you today, whether or not you have insurance. Enter your ZIP above to compare.
Other quit-smoking options
- Varenicline (generic Chantix): a different, non-nicotine prescription pill for smoking cessation.
- Nicotine replacement therapy (patch, gum, lozenge): available over the counter, sometimes used alongside a prescription medicine.
- Bupropion XL (Wellbutrin XL and generic): the same active ingredient at a different dose/release schedule, but FDA-approved for depression, not smoking cessation.
Your prescriber can help you choose based on your health history and what's worked (or hasn't) before.
Safety information
This medicine is contraindicated in people with a seizure disorder or a current or prior diagnosis of bulimia or anorexia nervosa, and in anyone taking an MAOI within the last 14 days. Seizure risk increases with dose, so it should not be taken above the labeled daily amount. An earlier FDA boxed warning about serious mood and behavior changes with smoking-cessation medicines was removed in 2016 after a large clinical trial found the risk was lower than previously thought, but the current label still discusses possible changes in mood, behavior, or thinking, so tell your provider right away if these occur. This isn't a complete list of risks; talk with your prescriber or pharmacist about your health history.
This Bupropion Hcl Er (Smoking Det) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Bupropion Hcl Er (Smoking Det) on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.