Bupropion Hcl Er (Sr)
buPROPion HCl ER (SR) 150MG
What is Bupropion Hcl Er (Sr)?
Wellbutrin SR treats Major Depression Disorder (MDD) as well as depression caused by Seasonal Affective Disorder (SAD), Wellbutrin SR also assists with patients trying to quit smoking. The generic version is known as Bupropion hydrochloride and is an extended release tablet equivalent to Wellbutrin SR. The average cash price of Wellbutrin SR is around $516 for a supply of 60 tablets of 150 mg sustained release. You can save significantly on the price of Wellbutrin SR using Singlecare’s Wellbutrin SR discount card at participating pharmacies.Side Effects
- Thoughts of hurting yourself, worsening depression, severe agitation or confusion
- Seeing or hearing things that are not there, feeling like people are against you
- Seizures
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, glaucoma, mental illness (including bipolar disorder), or high blood pressure. Tell your doctor if you have a history of drug addiction or if you drink alcohol.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Increased risk of seizuresChanges in mood or behaviorHigh blood pressureSerious skin reactions
Prescription savings · · · ·
What is Bupropion Hcl Er (Sr) ?
Wellbutrin SR treats Major Depression Disorder (MDD) as well as depression caused by Seasonal Affective Disorder (SAD), Wellbutrin SR also assists with patients trying to quit smoking. The generic version is known as Bupropion hydrochloride and is an extended release tablet equivalent to Wellbutrin SR. The average cash price of Wellbutrin SR is around $516 for a supply of 60 tablets of 150 mg sustained release. You can save significantly on the price of Wellbutrin SR using Singlecare’s Wellbutrin SR discount card at participating pharmacies.- Thoughts of hurting yourself, worsening depression, severe agitation or confusion
- Seeing or hearing things that are not there, feeling like people are against you
- Seizures
- Sudden increase in energy, racing thoughts, trouble sleeping
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Chest pain, trouble breathing, fast, slow, or uneven heartbeat
- Eye pain, vision changes, seeing halos around lights
- Muscle or joint pain, fever with rash
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, glaucoma, mental illness (including bipolar disorder), or high blood pressure. Tell your doctor if you have a history of drug addiction or if you drink alcohol.
- For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
- This medicine may cause the following problems:Increased risk of seizuresChanges in mood or behaviorHigh blood pressureSerious skin reactions
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
- Zyban® is only part of a complete program to help you quit smoking. You may still want to smoke at times. Have a plan to cope with these situations.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Bupropion Hcl Er (Sr) Coupons & Prices
buPROPion HCl ER (SR) 150MG
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Looking for a bupropion HCl ER (SR) coupon? Bupropion is the low-cost generic of Wellbutrin SR, and because it is a widely stocked generic you do not need a paper coupon to pay a fair cash price. What you pay can still vary a lot from one pharmacy to the next, so comparing matters. Rx.com checks the cash price across more than 60,000 U.S. pharmacies so you can find the lowest one near you. Enter your ZIP above to see today's price and print or text a free Rx.com discount card.
What is bupropion HCl ER (SR) and how does it work?
Bupropion is an aminoketone antidepressant known as a norepinephrine-dopamine reuptake inhibitor (NDRI). The sustained-release (SR) tablet is FDA-approved to treat major depressive disorder (MDD) in adults and is normally taken twice a day. It is the generic form of Wellbutrin SR and contains the same active ingredient as the other bupropion products on the market, including Wellbutrin XL and bupropion HCl XL.
The identical molecule at the same SR dosing is FDA-approved under the brand Zyban as an aid to smoking cessation. Your prescriber decides which product and dose fit your situation. This page is general information, not medical advice.
Bupropion SR cost without insurance
Because bupropion SR is an established generic, the cash price is usually modest compared with the brand. There is no manufacturer copay or savings card for the generic, so the honest way to lower your cost is simply to compare pharmacies. The same prescription can cost noticeably more at one pharmacy than at another down the street, which is why price-shopping pays off.
Rx.com compares the cash price at more than 60,000 U.S. pharmacies and shows you a free discount card you can use with or without insurance. Enter your ZIP above to see today's price near you, then bring the card to the counter.
Related bupropion products and alternatives
Bupropion comes in more than one release form, which is the most common point of confusion. The main options are:
- Wellbutrin SR - the brand version of this same sustained-release tablet, taken twice daily.
- Wellbutrin XL and its generic bupropion HCl XL - an extended-release tablet taken once daily.
- Zyban - the same molecule FDA-approved specifically as a stop-smoking aid.
- Bupropion-naltrexone (Contrave) - a combination product used for weight management.
Which form is right for you is a decision for your prescriber. If they switch you between forms, ask the pharmacist to confirm the strength and dosing, and compare the price of each option here before you fill.
Safety and important warnings
Bupropion carries an FDA boxed warning for an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults under 25 who take antidepressants; patients should be watched closely, especially early in treatment and after any dose change. Bupropion also has a dose-dependent risk of seizures. It should not be used by people with a seizure disorder, with a current or past diagnosis of bulimia or anorexia nervosa, or during abrupt withdrawal from alcohol, benzodiazepines, barbiturates, or antiseizure drugs, since all of these raise seizure risk.
Do not take bupropion with a monoamine oxidase inhibitor (MAOI); allow at least 14 days between the two. Never combine more than one bupropion-containing product, because that raises the risk of overdose and seizure. Bupropion can also cause high blood pressure, insomnia, and agitation, and rare serious neuropsychiatric effects such as mood changes, hostility, or psychosis. Tell your provider about liver or kidney problems and all other medicines you take. This is a summary, not a full list; talk to your doctor or pharmacist before starting or stopping this medication.
This Bupropion Hcl Er (Sr) information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Bupropion Hcl Er (Sr) on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.