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Abilify Maintena Prefilled Syringe — prescription drug image

Abilify Maintena

Abilify Maintena 400MG

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What is Abilify Maintena?

Abilify Maintena is used to treat schizophrenia. Abilify Maintena is the brand name of aripiprazole. The average Abilify Maintena price is about $1,771 for 1, 300 mg extended-release intramuscular powder for injection. You can use our Single Care savings offer to get an Abilify Maintena discount of up to 80% off of the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Abilify Maintena ?

Abilify Maintena is used to treat schizophrenia. Abilify Maintena is the brand name of aripiprazole. The average Abilify Maintena price is about $1,771 for 1, 300 mg extended-release intramuscular powder for injection. You can use our Single Care savings offer to get an Abilify Maintena discount of up to 80% off of the retail price at participating pharmacies near you.
  • Lightheadedness, dizziness, fainting
  • Unusual tiredness or sleepiness
  • Increased hunger or thirst, change in how much or how often you urinate
  • Seizures
  • Sweating, uneven heartbeat, muscle stiffness
  • Confusion, unusual behavior, depressed mood, or thoughts of hurting yourself or others
  • Jerky muscle movements that you cannot control (often in your face, tongue, or jaw)
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, irritability, nervousness, restlessness, trouble sleeping
  • Compulsive behavior or intense urges you cannot control
  • Fever, chills, cough, sore throat, body aches
  • Tell your doctor if you are pregnant or breastfeeding, or if you have diabetes, heart failure, heart or blood vessel disease, heart rhythm problems, high or low blood pressure, high cholesterol, or a history of seizures, heart attack, or stroke.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause the following problems: Neuroleptic malignant syndrome (NMS), a neurologic disorder which can be life-threateningTardive dyskinesia (movement disorder that may become permanent)Changes in blood sugar levelsUnusual changes in behavior, including gambling urges, binge or compulsive eating, compulsive shopping, or sexual urges
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
  • You may get overheated more easily while you are receiving this medicine. Be careful when you exercise or you are outside in hot or humid weather. Drink plenty of water to stay hydrated.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Seizures
  • Unusual moods or behavior, thoughts of hurting yourself
  • Unusual tiredness or sleepiness
What is Abilify Maintena used for?
Abilify Maintena is FDA-approved in adults to treat schizophrenia and for maintenance monotherapy treatment of bipolar I disorder. It is a long-acting injectable form of aripiprazole. It is not approved for dementia-related psychosis.
How often is Abilify Maintena injected?
It is given as a 400 mg intramuscular injection once a month, and no sooner than 26 days after the previous dose. The dose can be lowered to 300 mg if you have side effects. A healthcare professional gives it into the deltoid or gluteal muscle. If you are new to aripiprazole, you first establish tolerability with oral aripiprazole, and you continue an oral antipsychotic for 14 consecutive days after the first injection.
Is there a generic version of Abilify Maintena?
No. There is no FDA-approved, substitutable generic of Abilify Maintena, so it is brand-only. Oral aripiprazole is available as a generic, but it is a different formulation and is not a substitute for the monthly injection. Only your prescriber can decide whether a different form makes sense for you.
What are the side effects of Abilify Maintena?
Injection-site reactions and akathisia (restlessness) are common. The label also warns about neuroleptic malignant syndrome, tardive dyskinesia, metabolic changes including high blood sugar, abnormal cholesterol and weight gain, compulsive behaviors such as pathological gambling, low blood pressure on standing and fainting, low white blood cell counts, seizures, trouble regulating body temperature, swallowing problems, and impaired thinking or coordination. It carries a boxed warning about increased death in elderly patients with dementia-related psychosis. Ask your provider about any symptom that concerns you.
What is the difference between Abilify Maintena and Abilify Asimtufii?
Both are aripiprazole extended-release injectable suspensions, but the dosing interval differs. Abilify Maintena is injected once a month, while Abilify Asimtufii is injected once every two months. Aristada is a separate product containing aripiprazole lauroxil, a different prodrug, and is not the same medicine as either.
How much does Abilify Maintena cost without insurance?
The cash price varies by pharmacy and by location, and because Abilify Maintena is brand-only there is no generic to fall back on. Enter your ZIP code above to see today's price near you with the free Rx.com coupon. If you have commercial insurance, the manufacturer's official savings card program may also help, though eligibility and terms vary. Otsuka's patient assistance program may be an option if you qualify.
How much does Abilify Maintena cost without insurance?
The price of Abilify Maintena without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Abilify Maintena?
Common side effects of Abilify Maintena may include: Lightheadedness, dizziness, fainting, Unusual tiredness or sleepiness, Increased hunger or thirst, change in how much or how often you urinate, Seizures, Sweating, uneven heartbeat, muscle stiffness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Abilify Maintena?
Generic versions may be available for Abilify Maintena. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Abilify Maintena on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Abilify Maintena?
The cheapest pharmacy for Abilify Maintena depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Abilify Maintena near you.

Abilify Maintena Coupons & Prices

Abilify Maintena 400MG

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Abilify Maintena Prefilled Syringe — prescription drug image
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Abilify Maintena 400mg (0.4)
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An Abilify Maintena coupon from Rx.com can lower what you pay out of pocket for aripiprazole extended-release injectable suspension, the once-monthly long-acting antipsychotic injection given by a healthcare professional. Abilify Maintena is brand-only right now, so there is no generic version to switch to, and the cash price varies quite a bit from one pharmacy to the next. Enter your ZIP code above to see today's price near you, then bring the free coupon to the pharmacy. It is not insurance, and you can use it whether you have no coverage, have Medicare, or were turned down for the manufacturer's savings card.

What is Abilify Maintena and how does it work?

Abilify Maintena is a long-acting intramuscular (IM) injection of aripiprazole, an atypical (second-generation) antipsychotic. Aripiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and as an antagonist at 5-HT2A receptors. The extended-release suspension is designed to release medicine slowly over about a month, so one injection replaces daily pill-taking. It is not a controlled substance.

The FDA has approved Abilify Maintena in adults for two uses: treatment of schizophrenia, and maintenance monotherapy treatment of bipolar I disorder. The usual dose is 400 mg injected once a month, no sooner than 26 days after the previous dose, and it can be reduced to 300 mg if you have side effects. A healthcare professional gives the shot into the deltoid or gluteal muscle. It must never be given into a vein or under the skin. If you have not taken aripiprazole before, your provider will have you try oral aripiprazole first to be sure you tolerate it, and you keep taking an oral antipsychotic for 14 days in a row after the first injection. Abilify Maintena is not approved for dementia-related psychosis.

Manufacturer savings card vs. the Rx.com cash coupon

Otsuka runs an official savings card program for Abilify Maintena, described on the manufacturer's own Abilify Maintena website. Like most brand copay cards, it is generally limited to people with commercial (private) insurance, and the terms, eligibility, and any limits vary and change over time, so read the current program rules before you count on it. People with Medicare, Medicaid, or other government coverage are typically not eligible. Otsuka also runs a patient assistance program (Otsuka Patient Assistance) for people who qualify based on income and coverage, which is worth asking about if the drug is out of reach.

The Rx.com coupon is different: it is a free cash-price discount, not insurance and not tied to your coverage type. That makes it useful when you are uninsured, when you have Medicare and cannot use a copay card, or when the manufacturer's card is declined. Cash prices for a brand-only injectable vary by pharmacy, so it pays to compare rather than assume. Enter your ZIP above to see today's price at pharmacies near you. Because a healthcare professional has to administer the injection, ask your clinic how they source the medicine, since some clinics buy and bill for it themselves while others have you fill it at a pharmacy and bring it in.

Alternatives and related aripiprazole options

Aripiprazole comes in several forms, and the right one depends on your diagnosis, how often you want an injection, and what your provider recommends. Do not switch products on your own.

  • Abilify and generic aripiprazole are the oral forms taken daily. Oral aripiprazole is also what you use to establish tolerability before your first Maintena injection and for the 14 days after it.
  • Abilify Asimtufii is also aripiprazole extended-release injectable suspension, but it is dosed once every two months instead of once a month.
  • Aristada is aripiprazole lauroxil, a different prodrug of aripiprazole, and is not interchangeable with Abilify Maintena.
  • Invega Sustenna (paliperidone palmitate) and Risperdal Consta (risperidone) are long-acting injectables in the same broad drug class but with different active ingredients.

There is no substitutable generic of Abilify Maintena, so a generic swap is not a savings lever here the way it is with oral aripiprazole. Compare the cash price with your coupon, check the manufacturer's program if you have commercial insurance, and ask your prescriber whether a different form or interval fits your situation.

Safety information you should know

Abilify Maintena carries a boxed warning: elderly patients with dementia-related psychosis treated with antipsychotic drugs are at increased risk of death. Abilify Maintena is not approved for dementia-related psychosis. The label also warns about cerebrovascular problems including stroke in elderly patients with dementia, neuroleptic malignant syndrome, tardive dyskinesia (which may not go away), metabolic changes such as high blood sugar or new diabetes, abnormal cholesterol and weight gain, pathological gambling and other compulsive behaviors, low blood pressure on standing and fainting, low white blood cell counts, seizures, trouble with body temperature regulation, and swallowing difficulty. Aripiprazole can impair thinking and coordination, so be careful driving until you know how it affects you.

Injection-site reactions and akathisia (restlessness) are common. Tell your provider about all your medicines: doses need to be adjusted for CYP2D6 poor metabolizers and when taking CYP3A4 or CYP2D6 inhibitors, and CYP3A4 inducers should be avoided for more than 14 days. Contact your provider promptly about high fever with muscle stiffness and confusion, uncontrollable movements, new urges to gamble or shop or eat compulsively, fainting, or signs of infection. This page is general information, not medical advice. Talk with your doctor or pharmacist about what is right for you.

Sources & accuracy

This Abilify Maintena information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Abilify Maintena on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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