Acitretin
Acitretin 25MG
What is Acitretin?
Acitretin is a generic drug used in the treatment of severe skin conditions including psoriasis. The average Acitretin price is about $1,914 for a supply of 30 capsules, 25 mg oral capsules. You can use our Rx.com savings offer to get an Acitretin discount of up to 80% off of the retail price at participating pharmacies near you.Side Effects
- Chest pain, trouble breathing, unusual sweating, faintness, severe headache
- Severe headache, nausea, vomiting, and blurred vision
- Feeling depressed, thoughts of hurting yourself or others, unusual mood or behavior
Warnings
- It is not safe to take this medicine during pregnancy because it can cause very serious birth defects. You must use 2 forms of birth control for 1 month before you start taking acitretin, for the entire time you are being treated, and for 3 years after you take your last dose. Tell your doctor right away if you become pregnant.
- Tell your doctor if you have kidney disease, liver disease, bone or muscle problems, diabetes, eye or vision problems, heart disease, high cholesterol or triglyceride levels, or a history of depression. Tell your doctor if you are also receiving light therapy (phototherapy).
- This medicine may cause the following problems:Liver problemsBone or muscle problemsPancreatitis (swelling of the pancreas)Benign intracranial hypertension (increased pressure in the brain)Capillary leak syndrome (blood vessel problem)Depression or changes in mood or behavior
- Do not donate blood during the time you are being treated with this medicine and for at least 3 years after you take your last dose.
- This medicine may cause blurred vision or a decrease in night vision (night blindness). Do not drive or do anything else that could be dangerous if you are not able to see well.
Prescription savings · · · ·
What is Acitretin ?
Acitretin is a generic drug used in the treatment of severe skin conditions including psoriasis. The average Acitretin price is about $1,914 for a supply of 30 capsules, 25 mg oral capsules. You can use our Rx.com savings offer to get an Acitretin discount of up to 80% off of the retail price at participating pharmacies near you.- Chest pain, trouble breathing, unusual sweating, faintness, severe headache
- Severe headache, nausea, vomiting, and blurred vision
- Feeling depressed, thoughts of hurting yourself or others, unusual mood or behavior
- Cloudy urine, lightheadedness, fever, swelling of your hands, ankles, feet, or lower legs
- Increased hunger or thirst, increase in how much or how often you urinate
- Joint pain or stiffness
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Changes in vision (especially at night), eye pain or irritation, blurred vision
- It is not safe to take this medicine during pregnancy because it can cause very serious birth defects. You must use 2 forms of birth control for 1 month before you start taking acitretin, for the entire time you are being treated, and for 3 years after you take your last dose. Tell your doctor right away if you become pregnant.
- Tell your doctor if you have kidney disease, liver disease, bone or muscle problems, diabetes, eye or vision problems, heart disease, high cholesterol or triglyceride levels, or a history of depression. Tell your doctor if you are also receiving light therapy (phototherapy).
- This medicine may cause the following problems:Liver problemsBone or muscle problemsPancreatitis (swelling of the pancreas)Benign intracranial hypertension (increased pressure in the brain)Capillary leak syndrome (blood vessel problem)Depression or changes in mood or behavior
- Do not donate blood during the time you are being treated with this medicine and for at least 3 years after you take your last dose.
- This medicine may cause blurred vision or a decrease in night vision (night blindness). Do not drive or do anything else that could be dangerous if you are not able to see well.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Your psoriasis may get worse for a short time before it starts to improve. It may take 8 weeks or longer before your skin starts to look and feel better.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Severe headache, nausea, vomiting, and blurred vision
Acitretin Coupons & Prices
Acitretin 25MG
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Looking for an acitretin coupon? Acitretin is the generic oral retinoid prescribed for severe psoriasis, and because it's only sold as a generic today (the original brand, Soriatane, is no longer marketed in the US), what you pay can still vary widely from one pharmacy to the next. Rx.com compares pricing across more than 60,000 U.S. pharmacies so you can see where your prescription costs less before you fill it — enter your ZIP above to see today's price near you.
What Is Acitretin and How Does It Work?
Acitretin is a systemic (oral) retinoid, related to vitamin A, that's FDA-approved for adults with severe psoriasis, including plaque, erythrodermic, and palmoplantar/pustular forms. It works from within the body to affect the rapid skin-cell turnover that drives psoriasis. Dermatologists also prescribe it off-label for other conditions involving abnormal skin cell growth or keratinization, such as lichen planus, certain ichthyoses and Darier disease, pityriasis rubra pilaris, and to help prevent skin cancers in organ-transplant recipients.
Acitretin was originally sold under the brand name Soriatane, but that brand has been discontinued in the US — today it's available only as generic acitretin.
Acitretin Coupons and Pricing: What to Know
Because acitretin is generic-only, you may see it advertised across the usual cash-coupon sites (GoodRx, SingleCare, WellRx, and similar). What most of those pages don't make clear is that the price for the same generic prescription can differ significantly from pharmacy to pharmacy in the same city, since each pharmacy sets its own cash price and accepts different discount networks. That's exactly why comparing matters, even for a drug that's been generic for years.
Rx.com pulls live pricing from over 60,000 pharmacies nationwide so you can compare your options side by side rather than assuming the first price you see is the best one. Enter your ZIP code above to check today's acitretin prices near you, and always confirm your insurance or pharmacy discount at the counter, since cash and coupon prices can beat insurance copays for some patients.
Acitretin vs. Other Psoriasis Treatments
Acitretin is one of several systemic options dermatologists use for moderate-to-severe psoriasis, and the right choice depends on a patient's health history, other medications, and how severe the disease is. Related options include:
- Methotrexate — a long-used systemic option for psoriasis.
- Cyclosporine — another systemic immunosuppressant sometimes used for severe or fast-flaring psoriasis.
- Apremilast — an oral, non-biologic medication used for plaque psoriasis.
- Isotretinoin — a related oral retinoid, though it's primarily indicated for severe acne rather than psoriasis.
- Tretinoin — a topical retinoid used for acne and other skin conditions, distinct from acitretin's oral, systemic use.
This isn't a recommendation to switch medications — only your prescriber can weigh which treatment fits your specific diagnosis and health history.
Acitretin Safety Information
Acitretin carries boxed warnings from the FDA. The most serious is extreme teratogenicity: acitretin is contraindicated in pregnancy and in women who could become pregnant within 3 years of stopping treatment, because alcohol use during treatment or in the two months after can convert acitretin into a longer-lived teratogenic compound (etretinate) that extends that risk window. The second boxed warning is hepatotoxicity — roughly one in three patients develop elevated liver enzymes, so prescribers order liver function tests before and periodically during treatment; acitretin is contraindicated in severe liver or kidney impairment and in patients with significant chronic high cholesterol/triglycerides.
Other risks include marked increases in triglycerides or cholesterol (requiring lipid monitoring), skeletal changes (hyperostosis) with long-term use, pseudotumor cerebri, night blindness or other vision changes, and increased sun sensitivity. Blood donation is not permitted during treatment or for 3 years afterward. This is general information, not medical advice — talk with your prescriber about monitoring and precautions specific to you.
This Acitretin information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Acitretin on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.