Aklief
Aklief 45GM of 0.005%
What is Aklief?
Aklief (trifarotene) is a topical medication specifically designed to treat acne. As a retinoid, it works by modifying gene expression to reduce inflammation and normalize skin cell turnover, effectively targeting acne at its source. Aklief is suitable for use on both the face and trunk areas and has been approved for patients 9 years of age and older.Side Effects
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blisters, swelling, rash, or red, scaly, crusty skin
- Severe skin itching, burning, redness, peeling, or pain
Warnings
- Tell your doctor if you are pregnant, or if you have eczema, other skin problems, or sunburn.
- Tell your doctor if you are breastfeeding or planning to breastfeed. Do not apply the cream directly to the nipple and areola to avoid direct exposure to the baby.
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- This medicine makes your skin more sensitive to irritation and more likely to burn. Avoid exposing your skin to wind, cold weather, and sunlight, even on cloudy days. Do not use a sunlamp or tanning bed. Use a sunscreen or sunblock lotion with a sun protection factor (SPF) of at least 15 on a regular basis. Wear protective clothing when you are outside.
- Avoid the use of waxing as a hair removal method on the skin treated with this medicine.
Prescription savings · · · ·
What is Aklief ?
Aklief (trifarotene) is a topical medication specifically designed to treat acne. As a retinoid, it works by modifying gene expression to reduce inflammation and normalize skin cell turnover, effectively targeting acne at its source. Aklief is suitable for use on both the face and trunk areas and has been approved for patients 9 years of age and older.- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blisters, swelling, rash, or red, scaly, crusty skin
- Severe skin itching, burning, redness, peeling, or pain
- Tell your doctor if you are pregnant, or if you have eczema, other skin problems, or sunburn.
- Tell your doctor if you are breastfeeding or planning to breastfeed. Do not apply the cream directly to the nipple and areola to avoid direct exposure to the baby.
- Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.
- This medicine makes your skin more sensitive to irritation and more likely to burn. Avoid exposing your skin to wind, cold weather, and sunlight, even on cloudy days. Do not use a sunlamp or tanning bed. Use a sunscreen or sunblock lotion with a sun protection factor (SPF) of at least 15 on a regular basis. Wear protective clothing when you are outside.
- Avoid the use of waxing as a hair removal method on the skin treated with this medicine.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Aklief Coupons & Prices
Aklief 45GM of 0.005%
4 ED medications in one dose
Sildenafil, tadalafil, PT-141 & L-Citrulline · Works in ~15 min · Lasts up to 36 hours
Aklief prices by dosage
Lowest cash price with a free Rx.com coupon vs. the average retail price.
| Dosage | Quantity | Retail price | Rx.com price |
|---|---|---|---|
| 45gm of 0.005% · Pump Btl | 45 | $928.99 | $673.96 |
Cash prices near ZIP 77433; updated regularly. Actual pharmacy price may vary.
Looking for an Aklief coupon? Aklief (trifarotene) is a once-daily topical retinoid approved for acne vulgaris in patients 9 and older, and since there's no generic version yet, the manufacturer's savings card and Rx.com's cash coupon are the two main ways to lower what you pay at the pharmacy counter — enter your ZIP above to see today's price near you.
What Is Aklief and How Does It Work?
Aklief is the brand name for trifarotene, a topical retinoid that selectively targets the RAR-gamma receptor in the skin. It's FDA-approved for the topical treatment of acne vulgaris in patients 9 years of age and older. Aklief cream is applied once daily in the evening to the face, and optionally to acne-prone areas on the chest, shoulders, and back.
There is no significant off-label use pattern reported for Aklief; it is used specifically as an acne treatment as directed by the prescribing label.
Manufacturer Savings Card vs. Rx.com Cash Coupon
Aklief does not yet have an FDA-approved generic version (trifarotene), so brand-name pricing strategies matter here. Aklief's manufacturer offers an official savings card program through the Aklief brand website, but like most manufacturer copay cards, it's generally limited to patients with commercial insurance — terms, eligibility, and any caps can change, so check the manufacturer's site directly for current details. It typically isn't usable if you're uninsured, on Medicare, or if your insurance plan rejects the claim.
That's where the Rx.com cash coupon can help: it works regardless of insurance status, including for the uninsured, Medicare patients, or anyone whose manufacturer card gets declined at the register. Enter your ZIP code above to compare today's cash price at pharmacies near you.
Aklief vs. Other Retinoids: How It Compares
Aklief belongs to the same broad drug class as several other topical retinoids used for acne, though each has its own approval details and formulation. Related options patients often ask about include tretinoin, adapalene, tazarotene, Differin (adapalene), and combination products like Epiduo.
Because each retinoid has different concentrations, approved age ranges, and formulations, ask your provider or pharmacist which option best fits your skin and treatment goals rather than switching on your own.
Aklief Safety Information
Aklief does not carry a boxed warning. It can increase skin sensitivity to sunlight, so it's important to limit sun exposure and use sunscreen or protective clothing while using it, and to avoid tanning beds or sunlamps. Avoid combining Aklief with other potentially irritating products, such as medicated or abrasive cleansers or products with high alcohol or astringent content, and try to limit exposure to harsh weather (wind, cold) which can add to irritation.
- Common effects include application-site irritation, dryness, peeling, and itching
- Avoid contact with the eyes, lips, nasolabial folds, and mucous membranes
- Not recommended during pregnancy, based on limited human data and animal studies of retinoids
This is general information, not medical advice — talk to your doctor or pharmacist about whether Aklief is right for you.
This Aklief information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Aklief on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
Related Drugs
Browse more medications: starting with A · full A-Z directory · by condition · common drugs
Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.
