Anagrelide Hcl Coupons & Prices

An anagrelide hcl coupon from Rx.com can be used at the pharmacy counter when you are paying cash for anagrelide hydrochloride, the generic form of Agrylin. Anagrelide is a platelet-reducing medicine prescribed to lower a high platelet count in people with myeloproliferative neoplasms such as essential thrombocythemia. Cash prices for the same capsules can differ a lot from one pharmacy to the next, even between stores a few miles apart, so it is worth comparing before you fill. Rx.com compares prices across more than 60,000 pharmacies. Enter your ZIP code above to see today's price for your strength and quantity near you.

What is anagrelide and how does it work?

Anagrelide hydrochloride is a platelet-reducing agent. The precise mechanism by which anagrelide lowers the platelet count is not fully known. What the label describes is that it reduces platelet production by the megakaryocytes in the bone marrow: in cell culture studies anagrelide suppressed transcription factors, including GATA-1 and FOG-1, that are needed for megakaryocytopoiesis, and blood from treated volunteers showed a disruption in the postmitotic phase of megakaryocyte development. Lowering the platelet count reduces the risk of blood clots (thrombosis) and helps ease the symptoms that go with a very high platelet count, including thrombo-hemorrhagic events.

It is FDA-approved for the treatment of thrombocythemia secondary to myeloproliferative neoplasms, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events. The label does not name specific myeloproliferative neoplasm subtypes. It is not used for reactive or secondary thrombocytosis. In practice it is often used as second-line cytoreduction when hydroxyurea is not tolerated or is not doing enough. Generic anagrelide hydrochloride comes as 0.5 mg and 1 mg capsules. A usual adult starting dose is 0.5 mg four times a day or 1 mg twice a day, then adjusted to keep the platelet count under 600,000/uL (ideally 150,000 to 400,000/uL), without exceeding 10 mg per day or 2.5 mg in a single dose. Your prescriber sets your dose; this page is information, not medical advice.

What anagrelide costs without insurance, and how a coupon helps

A generic version of anagrelide hydrochloride capsules is available in the US, so most people filling this prescription are getting the generic rather than brand-name Agrylin. That does not mean every pharmacy charges the same thing. Cash prices are set store by store, and the spread between the cheapest and the most expensive pharmacy in one ZIP code can be large. If you are paying without insurance, or your plan has a high deductible, the pharmacy you choose is often the single biggest factor in what you pay.

Rx.com compares cash prices across more than 60,000 pharmacies so you can see the range before you hand over the prescription. Enter your ZIP above to see today's price, then bring the coupon to the counter and ask the pharmacist to run it as a cash discount instead of your insurance if it comes out lower. Because anagrelide is taken long term and the dose gets adjusted during the first weeks, it is worth re-checking prices when your strength or quantity changes. There is no manufacturer copay savings card offered for generic anagrelide; Takeda, which markets Agrylin, publishes its own patient support information on its official site, and terms vary.

Anagrelide compared with other options

Agrylin is the brand name for the same drug, anagrelide hydrochloride, from Takeda Pharmaceuticals America. The generic contains the same active ingredient and is usually the lower-cost way to fill it, though you should still compare pharmacies.

Anagrelide is not the only way to lower a high platelet count, and the choice belongs to you and your hematologist. Hydroxyurea (brand Hydrea) is commonly used first, with anagrelide often stepping in when hydroxyurea is not tolerated or is not working well enough. Jakafi (ruxolitinib) is used in certain myeloproliferative neoplasms. Low-dose aspirin is sometimes used alongside cytoreduction to reduce clotting risk, but combining it with anagrelide raises bleeding risk (see below), so only take aspirin with anagrelide if your prescriber has told you to.

Anagrelide safety, side effects, and monitoring

Anagrelide does not carry a boxed warning, but its label describes several important risks. Cardiovascular toxicity has been reported, including QT prolongation, torsades de pointes, and ventricular tachycardia. The label directs prescribers to obtain a pre-treatment cardiovascular examination including an ECG in all patients, and to monitor for cardiovascular effects during treatment; anagrelide should be used cautiously if you have known or suspected heart disease or take other medicines that prolong the QT interval. Pulmonary hypertension has been reported, and a cardiopulmonary assessment is recommended before starting. Pulmonary toxicity such as interstitial lung disease or pneumonitis can occur; the drug should be stopped if that is suspected. Bleeding risk goes up when anagrelide is combined with aspirin, and a postmarketing study found more major hemorrhagic events with the combination. Liver problems increase drug exposure: anagrelide is not recommended in severe hepatic impairment, and moderate impairment calls for a lower dose plus liver monitoring. It interacts with CYP1A2 inhibitors (such as fluvoxamine and ciprofloxacin), which can raise anagrelide exposure, and with CYP1A2 inducers (such as omeprazole), which can lower it, and with other PDE3 inhibitors (cilostazol, milrinone). If you are pregnant or planning a pregnancy, talk it through with your prescriber, who can weigh your treatment against the risks that thrombocythemia itself can carry in pregnancy.

The most common side effects are headache, palpitations, diarrhea, weakness or lack of energy (asthenia), swelling (edema), nausea, abdominal pain, dizziness, and fast heartbeat. Your platelet count must be checked every two days during the first week and weekly after that until you reach a maintenance dose. Do not stop anagrelide on your own: stopping abruptly can cause rebound thrombocytosis. Tell your prescriber about every medicine and supplement you take, and call them about chest symptoms, shortness of breath, a fast or irregular heartbeat, or unusual bleeding. This is general information and not a substitute for advice from your doctor or pharmacist.