Butalbital-Asa-Caff-Codeine
Butalbital-ASA-Caff-Codeine 50-325-40-30MG
What is Butalbital-Asa-Caff-Codeine?
Butalbital-ASA-Caff-Codeine is a combination medication used for the treatment of tension headaches. It contains butalbital, a barbiturate that helps relax muscle contractions; aspirin (ASA), an analgesic and anti-inflammatory; caffeine, a stimulant that enhances pain relief; and codeine, an opioid analgesic for additional pain control.Side Effects
- Change in how much or how often you urinate, painful urination
- Severe constipation or stomach pain
- Blistering, peeling, red skin rash
Warnings
- Tell your doctor if you are pregnant. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Do not breastfeed while you are using this medicine, unless you have your doctor's permission to do so.
- Tell your doctor if you have kidney disease, liver disease, Addison disease, lung or breathing problems (including asthma, COPD, sleep apnea), gallbladder problems, pancreas problems, an enlarged prostate, trouble urinating, an underactive thyroid, or stomach problems. Tell your doctor if you have a history of depression, head injury, seizures, or a history of drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Serotonin syndrome, when used with certain medicinesSleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Adrenal gland problemsLow blood pressureSeizuresStomach or bowel problems (including bleeding, ulcers, or perforation)Serious skin reaction, including drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
Prescription savings · · · ·
What is Butalbital-Asa-Caff-Codeine ?
Butalbital-ASA-Caff-Codeine is a combination medication used for the treatment of tension headaches. It contains butalbital, a barbiturate that helps relax muscle contractions; aspirin (ASA), an analgesic and anti-inflammatory; caffeine, a stimulant that enhances pain relief; and codeine, an opioid analgesic for additional pain control.- Change in how much or how often you urinate, painful urination
- Severe constipation or stomach pain
- Blistering, peeling, red skin rash
- Unusual bleeding, bruising, or weakness
- Changes in skin color, dark freckles, cold feeling, tiredness, weight loss
- Lightheadedness, dizziness, fainting
- Unusual bleeding, bruising, or weakness
- Bloody or black, tarry stools
- Blue lips, fingernails, or skin
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Tell your doctor if you are pregnant. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.
- Do not breastfeed while you are using this medicine, unless you have your doctor's permission to do so.
- Tell your doctor if you have kidney disease, liver disease, Addison disease, lung or breathing problems (including asthma, COPD, sleep apnea), gallbladder problems, pancreas problems, an enlarged prostate, trouble urinating, an underactive thyroid, or stomach problems. Tell your doctor if you have a history of depression, head injury, seizures, or a history of drug or alcohol abuse.
- This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Serotonin syndrome, when used with certain medicinesSleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Adrenal gland problemsLow blood pressureSeizuresStomach or bowel problems (including bleeding, ulcers, or perforation)Serious skin reaction, including drug reaction with eosinophilia and systemic symptoms (DRESS)
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children. This medicine may also cause a delay in ovulation for women and may affect their ability to have children.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- Trouble breathing, shallow breathing
- Unusual bleeding, bruising, or weakness
Butalbital-Asa-Caff-Codeine Coupons & Prices
Butalbital-ASA-Caff-Codeine 50-325-40-30MG
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If you're searching for a butalbital-asa-caff-codeine coupon, this medication is the generic version of Fiorinal with Codeine, a Schedule III combination of a barbiturate, a salicylate, caffeine, and the opioid codeine phosphate, and like most generics its cash price can differ substantially from pharmacy to pharmacy. Rx.com compares prices across more than 60,000 U.S. pharmacies, so enter your ZIP code above to see today's price near you before you fill this prescription.
What Is Butalbital, Aspirin, Caffeine, and Codeine?
Butalbital, aspirin, caffeine, and codeine phosphate is a four-ingredient combination medication: butalbital is a barbiturate, aspirin is a salicylate (NSAID-type pain reliever), caffeine is a CNS stimulant, and codeine phosphate is an opioid analgesic. It's FDA-approved for the symptomatic relief of the "symptom complex" of tension (muscle-contraction) headache in patients for whom non-opioid pain relievers and other treatments haven't been enough. It is not FDA-approved for migraine, and headache specialists generally advise against using butalbital- and opioid-containing combinations like this one for migraine: the American Headache Society's Choosing Wisely guidance recommends against opioid- or butalbital-containing treatments for migraine except as a last resort, because frequent use carries a meaningfully higher risk of medication-overuse (rebound) headache and dependence than migraine-specific treatments.
The standard label dosing is 1-2 capsules every 4 hours as needed, not to exceed 6 capsules in a 24-hour period. Because it contains codeine, it is a Schedule III controlled substance. The original brand was Fiorinal with Codeine, and generic versions of this combination, including one marketed as Ascomp with Codeine, are also available.
Comparing Pharmacy Prices
This drug is available generically, but generic pricing still varies by pharmacy, especially for a Schedule III controlled substance where stock levels and dispensing practices differ from store to store. There is no manufacturer copay or savings card for this medication. The most reliable way to find a fair price is to compare pharmacies directly rather than assume any one chain is cheapest.
Enter your ZIP code above to see today's price at pharmacies near you, and consider calling ahead to confirm a pharmacy has it in stock before you travel to fill it.
Related Medications and Alternatives
A few related combination products are worth knowing about, since your prescriber may consider them depending on your history and symptoms:
- Fiorinal — the same butalbital, aspirin, and caffeine combination but without codeine, so it is not a controlled opioid.
- Fioricet and butalbital/acetaminophen/caffeine — swap acetaminophen for aspirin, also without codeine.
- Acetaminophen with codeine — pairs codeine with acetaminophen instead of the butalbital/aspirin/caffeine combination.
- Codeine alone, without the barbiturate, salicylate, or caffeine components.
Only your prescriber can decide whether switching between these makes sense for you.
Safety Information
This medication carries an FDA boxed warning covering the risk of addiction, abuse, and misuse that can lead to overdose and death; the risk of life-threatening or fatal respiratory depression, especially when starting the drug or increasing the dose, which is worsened by alcohol, benzodiazepines, or other CNS depressants; the danger that even a single accidental dose can be fatal, especially in children; and the risk of neonatal opioid withdrawal syndrome with prolonged use during pregnancy. The codeine component also carries an added warning about life-threatening respiratory depression in children who are ultra-rapid metabolizers of codeine; it is contraindicated in children under 12 and in patients under 18 recovering from tonsillectomy or adenoidectomy. The aspirin component adds a risk of GI bleeding and Reye's syndrome in children or teens with a viral illness, and butalbital itself is habit-forming, with physical dependence and withdrawal possible after prolonged use.
It should not be combined with alcohol or with MAOIs (current use or within the past 14 days), and it is contraindicated in significant respiratory depression, acute or severe asthma, bleeding disorders such as hemophilia, or known hypersensitivity to any of its ingredients. This is general information, not medical advice — talk with your prescriber or pharmacist about whether this medication is right for you.
This Butalbital-Asa-Caff-Codeine information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Butalbital-Asa-Caff-Codeine on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.