Impact-Site-Verification: 2721d812-1059-4270-b9fa-5c1654788cd1

Dicloxacillin Sodium Capsule — prescription drug image

Dicloxacillin Sodium

Dicloxacillin Sodium 500MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes

What is Dicloxacillin Sodium?

Dicloxacillin Sodium is a semisynthetic antibiotic belonging to the penicillin class, specifically the isoxazolyl penicillins group. It is used primarily to treat infections caused by penicillinase-producing staphylococci, demonstrating effectiveness by inhibiting bacterial cell wall synthesis. Dicloxacillin is administered orally and is known for its resistance to degradation by stomach acid, enhancing its bioavailability.

Prescription savings · · · ·

What is Dicloxacillin Sodium ?

Dicloxacillin Sodium is a semisynthetic antibiotic belonging to the penicillin class, specifically the isoxazolyl penicillins group. It is used primarily to treat infections caused by penicillinase-producing staphylococci, demonstrating effectiveness by inhibiting bacterial cell wall synthesis. Dicloxacillin is administered orally and is known for its resistance to degradation by stomach acid, enhancing its bioavailability.
  • Severe diarrhea (watery, possibly with blood)
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Shortness of breath or trouble breathing
  • Severe diarrhea (watery, possibly with blood)
  • If you are pregnant or breast feeding, talk with your doctor before taking this medicine.
  • Make sure your doctor knows if you have ever had an allergic reaction to any cephalosporin antibiotic such as Keflex® or Ceclor® before you take this medicine.
What is dicloxacillin sodium used for?
Dicloxacillin sodium is FDA-approved to treat infections caused by penicillinase-producing staphylococci, most commonly skin and soft-tissue infections such as cellulitis, abscesses, and impetigo, and some respiratory tract infections, when the infection is proven or strongly suspected to be caused by a susceptible staph strain. It is not used for viral infections like colds or flu.
Is dicloxacillin the same as penicillin or amoxicillin?
No. Dicloxacillin is its own drug in the penicillin (beta-lactam) family, but it's a penicillinase-resistant, narrow-spectrum penicillin — meaning it was designed specifically to work against certain staph bacteria that break down regular penicillin. Amoxicillin and penicillin VK are different penicillin-class antibiotics used for a broader range of infections; they are not penicillinase-resistant and aren't used for the staph infections dicloxacillin treats. Your prescriber selects between them based on the bacteria involved.
How long does it take dicloxacillin to work on a skin infection?
There isn't one fixed timeline that applies to everyone — how quickly a skin infection responds depends on its severity and the individual. It's important to complete the full prescribed course of dicloxacillin even if you start feeling better, and to contact your provider if the infection doesn't seem to be improving as expected.
Can I drink alcohol while taking dicloxacillin?
There's no specific dicloxacillin-alcohol interaction noted in its labeling information here. As with any antibiotic, it's best to ask your pharmacist or prescriber directly about alcohol use during your course of treatment, since they can factor in your full health history.
Does dicloxacillin treat MRSA or staph infections?
Dicloxacillin treats certain staph infections — specifically those caused by penicillinase-producing staphylococci that are susceptible to it, such as some skin and soft-tissue infections. It is not effective against MRSA (methicillin-resistant Staphylococcus aureus), so it will not be prescribed for MRSA infections.
How much does Dicloxacillin Sodium cost without insurance?
The price of Dicloxacillin Sodium without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Dicloxacillin Sodium?
Common side effects of Dicloxacillin Sodium may include: Severe diarrhea (watery, possibly with blood), Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Shortness of breath or trouble breathing. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Dicloxacillin Sodium?
Generic versions may be available for Dicloxacillin Sodium. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Dicloxacillin Sodium on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Dicloxacillin Sodium?
The cheapest pharmacy for Dicloxacillin Sodium depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Dicloxacillin Sodium near you.

Dicloxacillin Sodium Coupons & Prices

Dicloxacillin Sodium 500MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Dicloxacillin Sodium Capsule — prescription drug image
Prescription
Dicloxacillin Sodium 500mg (20)
your area ·
Prescription weight loss

Weight-loss medication, prescribed online

Licensed U.S. providers · No insurance needed · Shipped to your door

$146/mo vs. brand-name GLP-1 medications $1,300+/mo Save up to 88%
See if I qualify Free online visit · No commitment
Compounded GLP-1 medications are not FDA-approved and are prepared by state-licensed compounding pharmacies. They are not affiliated with, endorsed by, or equivalent to any brand-name medication or manufacturer. Prescription required; eligibility is determined by a licensed provider. Prices are estimates and may vary.

Dicloxacillin sodium is a generic-only penicillin antibiotic — its former brand names are all discontinued in the US — but that doesn't mean every pharmacy charges the same price for it. If you're looking for a dicloxacillin sodium coupon, the biggest lever isn't finding a hidden discount, it's comparing pharmacies, since cash prices for this generic can vary widely from one drugstore to the next. Enter your ZIP above to see today's price at pharmacies near you; Rx.com compares 60,000+ pharmacies so you can find the lowest one without calling around.

What Is Dicloxacillin Sodium and How Does It Work?

Dicloxacillin sodium is a penicillinase-resistant (narrow-spectrum) penicillin antibiotic in the beta-lactam class. It's FDA-approved to treat infections caused by penicillinase-producing staphylococci — most often skin and soft-tissue infections such as cellulitis, abscesses, and impetigo, and some respiratory tract infections — when the infection is proven or strongly suspected to be caused by a susceptible staph strain. It was previously marketed under the brand names Dynapen, Dycill, and Pathocil, but all three have been discontinued in the US; today dicloxacillin sodium is available only as a generic.

Dicloxacillin is not a broad-spectrum, first-choice antibiotic — it's specifically used against staph infections that produce an enzyme (penicillinase) capable of breaking down other penicillins. It is not effective against MRSA (methicillin-resistant staph) or viral illnesses like colds and flu, so it won't be prescribed for those.

Dicloxacillin Sodium Cost and Coupon Savings

Because dicloxacillin sodium is generic, the underlying medication is already lower-cost than a brand-name drug — but cash prices for the same generic can still differ substantially from one pharmacy to the next, and there's no manufacturer savings card for this drug since there's no brand version left on the market. That makes shopping around the most reliable way to lower your out-of-pocket cost.

Rx.com compares dicloxacillin sodium prices across more than 60,000 U.S. pharmacies, including major chains and independents, so you can see which one near you charges the least before you fill your prescription. Enter your ZIP code above to check today's price at pharmacies in your area.

Dicloxacillin vs. Amoxicillin and Other Antibiotics

Dicloxacillin is one of several penicillin-family and related antibiotics used for bacterial infections, and your prescriber chooses between them based on the type of infection and the bacteria involved. Amoxicillin and penicillin VK are broader-use penicillins but aren't penicillinase-resistant, so they aren't used for the staph infections dicloxacillin targets. Amoxicillin-clavulanate adds a beta-lactamase inhibitor to amoxicillin to cover a wider range of resistant bacteria. For patients who can't take penicillins, prescribers may turn to a cephalosporin like cephalexin or, for penicillin-allergic patients, clindamycin.

These are different drugs for different clinical situations, not interchangeable substitutes — only your prescriber can determine which antibiotic is right for your specific infection.

Safety Information

Dicloxacillin sodium is contraindicated in anyone with a penicillin allergy, since it can cause a serious or anaphylactic allergic reaction — signs include swelling of the face, throat, or tongue, difficulty breathing, wheezing, or hives, and require immediate medical attention. As with other antibiotics, it carries a risk of Clostridioides difficile-associated diarrhea, which can occur up to two months or more after your last dose. Use caution if you have asthma or kidney disease, and be aware that dicloxacillin may reduce the effectiveness of hormonal birth control pills, so a back-up contraception method is advised. Take it on an empty stomach — one hour before or two hours after meals — with a full glass of water, and complete the entire prescribed course even if you start feeling better. This medication does not carry an FDA boxed warning.

This is general information, not medical advice — talk to your doctor or pharmacist about whether dicloxacillin sodium is right for you and about any other medications or conditions you have.

Sources & accuracy

This Dicloxacillin Sodium information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Dicloxacillin Sodium on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

Sponsored
Sesame Care — 350+ medications for $1 without insurance
¿Buscando esta página en español?

Browse more medications: starting with D · full A-Z directory · by condition · common drugs

Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


Don't Miss Out On Savings!

Rx.com does not warrant the accuracy of the information on this website. All information on this site is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of a drug is safe, appropriate, or effective for you. Consult your healthcare professional before using any drug. All logos, brand names and trademarks on this website are the property of their respective owners. Rx.com is not endorsed or affiliated with any brands represented on this website."

Pharmacy discounts are Not Insurance, and are Not Intended as a Substitute for Insurance THE DISCOUNT IS ONLY AVAILABLE AT PARTICIPATING PHARMACIES As an Amazon Associate, we earn from qualifying purchases.

2026 All Rights Reserved | Rx.com®