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Eligard

Eligard 1 Kit

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What is Eligard?

Eligard is a prescription-only medication that is used to lower testosterone levels in men diagnosed with prostate cancer. The generic name of Eligard is Leuprolide. The average Eligard price is about $480 for one, 7.5 mg/month subcutaneous powder for injection. Rx.com offers discounted prices to its customers on medications that they need. Our free coupon card can be printed and used at many well-known pharmacies in the U.S.

Prescription savings · · · ·

What is Eligard ?

Eligard is a prescription-only medication that is used to lower testosterone levels in men diagnosed with prostate cancer. The generic name of Eligard is Leuprolide. The average Eligard price is about $480 for one, 7.5 mg/month subcutaneous powder for injection. Rx.com offers discounted prices to its customers on medications that they need. Our free coupon card can be printed and used at many well-known pharmacies in the U.S.
  • Fast, pounding, or uneven heartbeat
  • Depression, mood or behavior changes
  • Dark urine or pale stools, loss of appetite, yellow skin or eyes
  • Sudden or severe headache, problems with vision, speech, or walking
  • Fever, chills, cough, runny or stuffy nose, sore throat, body aches
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Arm, leg, back, bone, or muscle pain, numbness or tingling in the body
  • Blurred or change in vision, eye pain, severe headache, fainting, dizziness, lightheadedness
  • Change in how much or how often you urinate, blood in the urine
  • Chest pain that may spread, trouble breathing, coughing up blood
  • Vaginal bleeding, discharge, itching, or pain
  • Unusual or severe bone or back pain
  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg
  • Dry mouth, fruit-like breath odor, nausea, vomiting, stomach pain, tiredness
  • Seizures
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Women who are using this medicine should use birth control that does not contain hormones (including condoms, spermicide).
  • Tell your doctor if you have kidney disease, liver disease, heart failure, diabetes, heart or blood vessel disease, heart rhythm problems (including long QT syndrome), problems with your nervous system, or a history of asthma, sinusitis, drug allergy, brain tumor, depression, mental illness, seizures, or stroke.
  • Women: Your menstrual periods should stop, but you might have light bleeding or spotting. If you continue to have heavy bleeding or regular periods, call your doctor.
  • This medicine may cause the following problems:Changes in mood or behaviorIncreased risk for seizuresHeart rhythm changes, including QT prolongationWeaker bones, which may lead to osteoporosisProblems with the urinary tract or spinal cord (in men)Increased risk of high blood sugar or cholesterol levels (in men)Increased risk of non-alcoholic fatty liver disease (in men)Increased risk of heart attack or stroke (in men)Intracranial hypertension or pseudotumor cerebri (increased pressure in the head) in children
  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
  • Your symptoms might get worse when you first start using this medicine, but they should get better as the medicine starts to work. If your condition does not begin to improve after 2 weeks, check with your doctor.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
What is Eligard used for?
Eligard is FDA-approved for the treatment of advanced prostate cancer. It is a form of androgen deprivation therapy: it lowers testosterone, which is what fuels most prostate cancer growth. Beyond the approved indication, treatment guidelines also support using androgen deprivation therapy alongside radiation therapy and with androgen receptor pathway inhibitors, though that combination use is guideline-based rather than part of Eligard's FDA-approved indication itself. Other leuprolide products, not Eligard, are the ones approved for endometriosis, uterine fibroids, and central precocious puberty.
How long does an Eligard injection last?
It depends on the strength your provider chooses. Eligard comes in four dosing strengths and intervals: 7.5 mg given monthly, 22.5 mg every 3 months, 30 mg every 4 months, and 45 mg every 6 months. Each is an extended-release depot injected under the skin by a healthcare provider, so the medicine is released slowly over that whole interval rather than all at once.
What are the most common side effects of Eligard?
The most common side effects, reported in 5% or more of patients, are hot flashes and sweats, malaise, fatigue, and testicular atrophy. Injection-site reactions such as burning, stinging, or pain are also common. A transient testosterone surge in the first weeks can cause tumor flare, which may temporarily worsen bone pain or urinary symptoms. Contact your care team about new bone pain, trouble urinating, or new leg weakness or numbness. Ask your provider about anything that concerns you.
Is there a generic version of Eligard?
No. There is no substitutable generic version of Eligard on the US market. Eligard uses the ATRIGEL extended-release delivery system, and other leuprolide products are different formulations rather than generic equivalents you can swap at the pharmacy: Lupron Depot is an intramuscular leuprolide acetate depot, and Camcevi is a leuprolide mesylate injectable emulsion. Because there is no generic to fall back on, comparing cash prices and checking manufacturer assistance options are your main ways to lower what you pay.
How much does Eligard cost without insurance?
The cash price varies by pharmacy, by which of the four strengths you are prescribed, and by whether the injection is billed through a pharmacy or through your clinic. Enter your ZIP above to see today's price near you with the Rx.com coupon, and compare that number against what your clinic quotes. If you have commercial insurance, manufacturer copay support may apply, though those programs generally exclude Medicare and Medicaid and their terms vary. Tolmar also publishes patient assistance and advocacy resources on its official site.
How much does Eligard cost without insurance?
The price of Eligard without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Eligard?
Common side effects of Eligard may include: Fast, pounding, or uneven heartbeat, Depression, mood or behavior changes, Dark urine or pale stools, loss of appetite, yellow skin or eyes, Sudden or severe headache, problems with vision, speech, or walking, Fever, chills, cough, runny or stuffy nose, sore throat, body aches. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Eligard?
Generic versions may be available for Eligard. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Eligard on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Eligard?
The cheapest pharmacy for Eligard depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Eligard near you.

Eligard Coupons & Prices

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Eligard (leuprolide acetate) is a brand-name injection used as androgen deprivation therapy for advanced prostate cancer, and there is no generic version of Eligard on the US market. Because it is given in a doctor's office or clinic rather than picked up at a retail counter, what you pay depends heavily on your coverage and where the injection is billed. If you are paying cash, use the Eligard coupon on this page: enter your ZIP above to see today's price at pharmacies near you, and compare that against what your clinic or insurer quotes before you schedule your next dose.

What Eligard is and how it works

Eligard is leuprolide acetate delivered as an extended-release subcutaneous depot using the ATRIGEL polymeric delivery system. It belongs to a class called gonadotropin-releasing hormone (GnRH) agonists, and it works as a hormonal antineoplastic agent: by continuously stimulating the GnRH receptor, it ultimately shuts down the signal that tells the body to make testosterone. Because most prostate cancer growth is fueled by testosterone, lowering testosterone is the point of the treatment. This approach is known as androgen deprivation therapy.

Eligard is FDA-approved for the treatment of advanced prostate cancer. A healthcare provider gives it as an injection under the skin in one of four strengths, each matched to a dosing interval: 7.5 mg monthly, 22.5 mg every 3 months, 30 mg every 4 months, and 45 mg every 6 months. In practice, and consistent with prostate cancer guidelines, it is also used alongside radiation therapy and with androgen receptor pathway inhibitors. Note that other leuprolide products (not Eligard) carry approvals for endometriosis, uterine fibroids, and central precocious puberty; those indications belong to those formulations, not to this one.

Eligard cost: manufacturer savings card vs. the Rx.com cash coupon

Search for an Eligard coupon and you will mostly find manufacturer programs and discount cards competing for your click. Here is the honest breakdown. Tolmar, the company behind Eligard, runs affordability and patient support resources through its official site, and information about patient assistance programs and advocacy resources is published there. Manufacturer copay support of this kind is generally limited to people with commercial (private) insurance, and it typically excludes anyone covered by Medicare, Medicaid, or other government programs. Terms, eligibility, and enrollment steps vary and can change, so check the manufacturer's own program details directly rather than relying on a third-party summary. If you have no insurance or your income is limited, ask your oncology office about the manufacturer's patient assistance route as well, since that is a separate pathway from copay support.

The Rx.com cash coupon fills the gap the manufacturer card leaves. It is a cash-pay discount, so it works whether you are uninsured, on Medicare, or simply told your card was declined. There is no generic Eligard, so shopping the cash price is the main lever you have. Prices vary a great deal from pharmacy to pharmacy, and because Eligard may be billed either through a pharmacy or through your clinic's buy-and-bill process, it is worth asking your care team which route they use. Enter your ZIP above to see today's price near you, then compare it with your clinic's and your plan's quote. You cannot use a manufacturer copay card and a cash coupon at the same time, so use whichever is lower for you.

Eligard alternatives and how they compare

Eligard is one of several leuprolide products. Lupron Depot is an intramuscular depot version of leuprolide acetate, the same active drug as Eligard, while Camcevi is a ready-to-use subcutaneous leuprolide mesylate emulsion rather than an acetate formulation. Other leuprolide acetate products exist in different forms as well. These are not simply interchangeable at the counter, because each one has its own salt form, strengths, dosing intervals, and preparation. Your provider chooses based on your treatment plan, not on price alone.

Beyond leuprolide, other hormonal options for prostate cancer include the GnRH antagonist Firmagon (degarelix) and the GnRH agonists Zoladex (goserelin) and Trelstar (triptorelin). Androgen receptor blockers such as Casodex (bicalutamide) and Xtandi (enzalutamide) work differently and are often used with, not instead of, androgen deprivation therapy. Some of these have generic versions and some do not, which can make a real difference to what you pay. This is a conversation for your oncologist, not a swap to make on your own.

Safety and side effects to know about

Eligard does not carry a boxed warning. The most common side effects reported in 5% or more of patients are hot flashes and sweats, malaise, fatigue, and testicular atrophy. Injection-site reactions such as burning, stinging, or pain are common with this subcutaneous depot. One effect specific to GnRH agonists is tumor flare: in the first weeks of treatment, testosterone briefly surges before it falls, and that surge can temporarily worsen bone pain, urinary or ureteral obstruction, blood in the urine, nerve pain, or, rarely, spinal cord compression. Tell your care team right away about new or worsening bone pain, trouble urinating, or any new weakness or numbness in your legs.

The label also flags hyperglycemia and new-onset diabetes, increased cardiovascular risk including heart attack, sudden cardiac death, and stroke, QT/QTc prolongation, convulsions, severe cutaneous adverse reactions, and embryo-fetal toxicity. Eligard may cause fetal harm and is not for use in females who are or may become pregnant. Separately, decreased bone mineral density is reported among the adverse reactions seen with leuprolide and is a known concern with long-term androgen deprivation, which is why blood sugar, heart health, and bone health monitoring are usually part of the plan. This page is information, not medical advice. Talk with your provider or pharmacist about your own situation, and read the full prescribing information for the complete list of risks.

Sources & accuracy

This Eligard information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Eligard on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.


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