Etonogestrel-Ethinyl Estradiol
Etonogestrel-Ethinyl Estradiol 1 Ring
What is Etonogestrel-Ethinyl Estradiol?
Etonogestrel-ethinyl estradiol is a combination hormonal contraceptive commonly used to prevent pregnancy. It includes etonogestrel, a progestin, and ethinyl estradiol, an estrogen, which work together to inhibit ovulation, thicken cervical mucus, and alter the uterine lining to prevent fertilization and implantation. This medication is typically administered through a vaginal ring, offering a user-friendly, once-a-month application.Side Effects
- Chest pain that may spread, trouble breathing, coughing up blood
- Numbness or weakness on one side of your body, pain in your lower leg, sudden or severe headache, problems with vision, speech, or walking
- Unusual or unexpected vaginal bleeding or heavy bleeding
Warnings
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you recently had a baby, miscarriage, or abortion. Tell your doctor if you have kidney disease, cervical cancer, diabetes, epilepsy, migraines, heart or blood vessel disease, high cholesterol, high blood pressure, or a history of depression or chloasma (skin discoloration on the face). Tell your doctor if you smoke or if you are having a surgery that requires inactivity for a long time.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsToxic shock syndromeLiver problemsHigh blood pressureGallbladder diseaseHigh cholesterol or fats in the bloodIncreased risk of breast or cervical cancer
- This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
Prescription savings · · · ·
What is Etonogestrel-Ethinyl Estradiol ?
Etonogestrel-ethinyl estradiol is a combination hormonal contraceptive commonly used to prevent pregnancy. It includes etonogestrel, a progestin, and ethinyl estradiol, an estrogen, which work together to inhibit ovulation, thicken cervical mucus, and alter the uterine lining to prevent fertilization and implantation. This medication is typically administered through a vaginal ring, offering a user-friendly, once-a-month application.- Chest pain that may spread, trouble breathing, coughing up blood
- Numbness or weakness on one side of your body, pain in your lower leg, sudden or severe headache, problems with vision, speech, or walking
- Unusual or unexpected vaginal bleeding or heavy bleeding
- Breast lumps, tenderness, pain, swelling, or discharge
- Fast, slow, or pounding heartbeat
- Sudden and severe stomach pain, nausea, vomiting, lightheadedness
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Vision loss, double vision
- Sudden high fever, diarrhea, dizziness, fainting, muscle aches, sunburn-like rash
- Dark urine or pale stools, loss of appetite, yellow skin or eyes
- Redness, pain, itching, or burning sensation inside your vagina
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you recently had a baby, miscarriage, or abortion. Tell your doctor if you have kidney disease, cervical cancer, diabetes, epilepsy, migraines, heart or blood vessel disease, high cholesterol, high blood pressure, or a history of depression or chloasma (skin discoloration on the face). Tell your doctor if you smoke or if you are having a surgery that requires inactivity for a long time.
- This medicine may cause the following problems:Increased risk of heart attack, stroke, or blood clotsToxic shock syndromeLiver problemsHigh blood pressureGallbladder diseaseHigh cholesterol or fats in the bloodIncreased risk of breast or cervical cancer
- This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
- This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases.
- You might have spotting or irregular bleeding when you first start using this medicine. You might have unplanned bleeding if you miss a dose or are late taking it. However, if you have heavy bleeding, call your doctor.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Etonogestrel-Ethinyl Estradiol Coupons & Prices
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An etonogestrel and ethinyl estradiol coupon from Rx.com can lower what you pay at the pharmacy counter for the generic birth control vaginal ring, the generic version of NuvaRing. Cash prices for the ring swing widely from one pharmacy to the next, even between stores on the same street, so it is worth checking before you fill. Rx.com compares prices at more than 60,000 pharmacies nationwide so you can see what the ring actually costs near you. Enter your ZIP code above to see today's price and print, text, or email a free coupon. There is no membership fee and no insurance required.
What is the etonogestrel and ethinyl estradiol vaginal ring, and how does it work?
Etonogestrel and ethinyl estradiol is a combined hormonal contraceptive (CHC) delivered as a soft, flexible vaginal ring. It pairs a progestin (etonogestrel) with an estrogen (ethinyl estradiol) and is FDA-approved to prevent pregnancy in females of reproductive potential. Once inserted, the ring releases an average of 0.120 mg of etonogestrel and 0.015 mg of ethinyl estradiol per day. It stays in place for three weeks, then is removed for a one-week ring-free interval, during which withdrawal bleeding usually happens. The brand name is NuvaRing. Generic versions of the same ring are also marketed in the US, such as EluRyng.
According to the FDA label, combined hormonal contraceptives work by suppressing the hormones that trigger ovulation, so an egg is usually not released. That is the primary effect. The label notes that other changes may also contribute, including changes in cervical mucus that make it harder for sperm to enter the uterus, and changes in the lining of the uterus. Important to know: the ring does not protect against HIV or other sexually transmitted infections. If STI protection matters for you, a barrier method such as a condom is still needed. This page is general information, not medical advice, so talk with your provider about whether the ring is a good fit for you.
What the ring costs without insurance, and how to pay less
There is no single national price for the etonogestrel and ethinyl estradiol ring. What you pay depends on the pharmacy you walk into and the ZIP code you are in, and prices for the same ring can differ a lot between nearby stores. A monthly ring is also a recurring expense, so a bad price repeats itself every cycle. That is why comparing before you fill matters more with this drug than with a one-time prescription.
A few practical ways to bring your cost down:
- Compare first. Enter your ZIP above to see prices at pharmacies near you and grab a free Rx.com coupon. Rx.com compares more than 60,000 pharmacies.
- Ask about the generic. Unless your prescriber has a reason to require brand NuvaRing, ask that the prescription be written so a pharmacist can dispense a generic ring. Whether the generic or the brand is cheaper for you still depends on the pharmacy and your coverage, so compare both.
- Ask about a multi-month supply. Some prescribers will write for more than one ring at a time, which can lower the per-cycle price. Check with the pharmacy on storage instructions.
- Compare the cash coupon price against your insurance copay. Many plans cover contraception with no cost-sharing, but not every plan covers every product, and a cash coupon price is sometimes the better deal. Use whichever is lower. You cannot combine a coupon with insurance on the same fill.
Generic rings do not have a manufacturer copay savings card. Organon, which makes brand NuvaRing, runs patient assistance and access programs for its products at organonhelps.com. Which products are covered, and the eligibility rules and terms, vary and change over time, so check with the program directly if you think you may qualify.
Alternatives and how the ring compares to the pill
The ring uses the same two hormone types found in most combination birth control pills, so if the ring is not right for you, there are several well-established options. The practical difference is the routine: the ring is placed once and replaced monthly, while pills must be taken every day at roughly the same time. Effectiveness in real life often comes down to which routine you can actually stick with.
Common alternatives your provider may discuss include:
- NuvaRing — the brand-name version of this exact ring.
- Norethindrone and ethinyl estradiol — a combination pill.
- Norgestimate and ethinyl estradiol — a combination pill.
- Levonorgestrel and ethinyl estradiol — a combination pill.
- Drospirenone and ethinyl estradiol — a combination pill.
- Etonogestrel — the progestin alone, used as a long-acting implant, which contains no estrogen.
All of the combination options above carry the same estrogen-related cautions as the ring. If estrogen is not safe for you, a progestin-only method may be the better conversation to have with your provider. Prices differ between all of these, so it is worth checking each one on Rx.com.
Safety information you should know
The ring carries a BOXED WARNING: cigarette smoking increases the risk of serious cardiovascular events from combined hormonal contraceptives. That risk goes up with age, particularly in women over 35, and with the number of cigarettes smoked. Women over 35 who smoke should not use the ring or any other combined hormonal contraceptive. The ring is also contraindicated if you have a high risk of blood clots in arteries or veins (including a current or past DVT or pulmonary embolism, certain heart valve or rhythm disorders, or an inherited or acquired clotting disorder), uncontrolled high blood pressure, diabetes with vascular disease, headaches with focal neurologic symptoms, migraine with aura, migraine without aura if you are over 35, current or past breast cancer or another estrogen- or progestin-sensitive cancer, liver tumors, acute hepatitis or decompensated cirrhosis, undiagnosed abnormal uterine bleeding, or if you are pregnant. It should not be taken with hepatitis C combinations containing ombitasvir, paritaprevir, and ritonavir because of a risk of liver enzyme elevation.
Other things the label flags: raised blood pressure, gallbladder disease, liver problems, effects on blood sugar and lipids, headache or migraine, irregular bleeding or missed periods, depression, vaginal irritation or discharge, and the ring slipping out or breaking. Toxic shock syndrome has been reported in ring users, so call your provider right away for sudden high fever with vomiting, diarrhea, dizziness, or a sunburn-like rash. Certain medicines can make the ring less effective at preventing pregnancy, including rifampin, some seizure medicines, St. John's wort, and some HIV protease inhibitors. Tell your pharmacist and prescriber everything you take. This is a summary, not a complete list, and it is not medical advice. Read the FDA label and talk with your healthcare provider before starting or stopping any birth control.
This Etonogestrel-Ethinyl Estradiol information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Etonogestrel-Ethinyl Estradiol on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.