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Folbic Tablet — prescription drug image

Folbic

Folbic 2.5-25-2MG

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What is Folbic?

Folbic is a dietary supplement used to treat vitamin deficiency in the body. Folbic contains a combination of vitamins and folic acid. You can use our Rx.com savings offer to get a Folbic discount of up to 80% off of the retail price at participating pharmacies near you.

Prescription savings · · · ·

What is Folbic ?

Folbic is a dietary supplement used to treat vitamin deficiency in the body. Folbic contains a combination of vitamins and folic acid. You can use our Rx.com savings offer to get a Folbic discount of up to 80% off of the retail price at participating pharmacies near you.
  • Skin tingling, burning, or itching
  • Mild diarrhea
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Unusual bleeding, bruising, or weakness
  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a history of pernicious anemia (not enough vitamin B12).
  • Unusual bleeding, bruising, or weakness
What is Folbic used for?
Folbic is used under a doctor's supervision to help lower elevated homocysteine levels (hyperhomocysteinemia), especially in people who have or are at risk for atherosclerotic vascular disease affecting the heart, legs, or brain, or who have vitamin B12 deficiency. It is also commonly used in patients with chronic kidney disease or on dialysis. It combines folic acid, vitamin B6, and vitamin B12.
Is Folbic a prescription drug or just a vitamin?
It is a prescription-marketed product, not an ordinary over-the-counter vitamin. Folbic is sold as a medical-food / unapproved-drug product at prescription-level strengths, and its folic acid content is well above what over-the-counter supplements are allowed to contain. It is meant to be used under a physician's supervision.
What is the difference between Folbic and regular folic acid?
Regular folic acid is a single B vitamin. Folbic combines folic acid with vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin) in one tablet, at higher, prescription-level strengths. The three vitamins work together in the body's pathways that process homocysteine, which is why they are combined.
What are the side effects of Folbic?
Folbic has no boxed warning. Hypersensitivity (allergic) reactions to the B12 component are possible. It is not appropriate for people with Leber's optic atrophy, and it can interact with levodopa (taken without carbidopa) because of the B6 component. High-dose folic acid can also hide the blood signs of B12 deficiency. Ask your doctor or pharmacist about side effects for your situation.
Is there a generic version of Folbic?
There are lower-cost equivalent combination products with the same three ingredients — folic acid / cyanocobalamin / pyridoxine tablets — that typically cost much less than the brand at the same strengths. Because Folbic is a medical-food / unapproved-drug product, it is not in the FDA's Orange Book and has no FDA therapeutic-equivalence (AB) rating, so your pharmacist cannot automatically substitute one for it; filling a lower-cost equivalent generally requires your prescriber to write for it (or depends on your state's rules). Ask your doctor or pharmacist, and use an Rx.com coupon to compare cash prices.
How much does Folbic cost without insurance?
The price of Folbic without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Folbic?
Common side effects of Folbic may include: Skin tingling, burning, or itching, Mild diarrhea, Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing, Unusual bleeding, bruising, or weakness. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Folbic?
Generic versions may be available for Folbic. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Folbic on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Folbic?
The cheapest pharmacy for Folbic depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Folbic near you.

Folbic Coupons & Prices

Folbic 2.5-25-2MG

Prescriptions & Refills
Licensed US providers · Online visit in minutes
Folbic Tablet — prescription drug image
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Folbic 2.5-25-2mg (14)
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Looking for a Folbic coupon? Folbic is a prescription-marketed vitamin B combination — folic acid, pyridoxine (vitamin B6), and cyanocobalamin (vitamin B12) — used under a doctor's supervision to help lower elevated homocysteine levels. Because it is dispensed at a pharmacy, you can use a free Rx.com cash coupon to bring down the cash price at the register, whether you are uninsured, on Medicare, or your plan does not cover it. Enter your ZIP above to see today's price at pharmacies near you.

What is Folbic and how does it work?

Folbic is a prescription-level combination of folic acid 2.5 mg, pyridoxine (vitamin B6) 25 mg, and cyanocobalamin (vitamin B12) 2 mg. It is marketed for the distinct nutritional requirements of patients being managed by a physician for hyperhomocysteinemia — elevated blood levels of the amino acid homocysteine — particularly those with or at risk for atherosclerotic vascular disease (coronary, peripheral, or cerebral) or vitamin B12 deficiency. It is also commonly used in people with chronic kidney disease or on dialysis, who often have trouble keeping these B vitamins in balance.

These three B vitamins work together in the body's pathways that break down and recycle homocysteine, which is why they are combined in one tablet at prescription strengths. Note that Folbic is marketed as a medical-food / unapproved-drug product rather than a drug with an FDA-approved indication, and its folate strength is well above what is allowed in over-the-counter supplements. It should be used only under a physician's supervision and is not a substitute for a balanced diet.

Folbic cost and savings: coupons, generics, and insurance

There is no manufacturer savings or copay card for Folbic, so the two main ways to lower your cost are your insurance and a cash discount. Manufacturer copay cards, where they exist for brand drugs, are generally limited to people with commercial (employer or marketplace) insurance and exclude Medicare, Medicaid, and the uninsured — with terms that vary. A free Rx.com cash coupon works differently: it is not insurance, so it can be used whether you are uninsured, on Medicare, or in any situation where a plan or card is declined. You simply present it at the pharmacy for a discounted cash price.

Because Folbic is marketed as a medical-food / unapproved-drug product, it is not listed in the FDA's Orange Book and has no FDA therapeutic-equivalence (AB) rating, so your pharmacist cannot automatically swap it for a generic the way they can with an approved brand drug. That said, lower-cost equivalent combination products with the same three ingredients — folic acid / cyanocobalamin / pyridoxine tablets — are sold and typically cost far less than the brand at the same strengths. Filling one of those in place of Folbic usually requires your prescriber to write for it (or is governed by your state's substitution rules), so ask your doctor or pharmacist, then enter your ZIP above to compare the cash price with and without an Rx.com coupon at pharmacies near you.

Folbic alternatives and similar B-vitamin combinations

Several prescription-marketed B-vitamin combinations pair folate with B6 and/or B12 for homocysteine management. Products in this family include Foltx, Folbee, and FaBB, along with other similar combinations such as Virt-Vite and Cerefolin. They differ in the exact vitamins and strengths they contain, so they are not always interchangeable — your prescriber chooses based on your needs.

If your doctor is targeting a single deficiency rather than a combination, the individual ingredients are also available on their own: folic acid, cyanocobalamin (vitamin B12), and pyridoxine (vitamin B6). Each can be priced separately with an Rx.com coupon — enter your ZIP above to compare.

Folbic safety and important warnings

Folbic has no boxed warning, but there are important cautions to review with your provider. It is contraindicated in Leber's optic atrophy, because the cyanocobalamin (B12) component can accelerate irreversible optic-nerve damage in that condition. The pyridoxine (B6) component antagonizes levodopa, so the combination should be avoided in patients taking levodopa without carbidopa. High-dose folic acid can also mask the blood-count signs of vitamin B12 deficiency (pernicious anemia) while nerve damage continues to progress, which is one reason a doctor should oversee its use.

Hypersensitivity reactions to cobalamin are possible. This page is not medical advice — tell your provider about all the medicines and supplements you take, and use Folbic only under physician supervision.

Sources & accuracy

This Folbic information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Folbic on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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