Lubiprostone
Lubiprostone 24MCG
What is Lubiprostone?
Lubiprostone is a chloride channel activator used primarily to treat chronic idiopathic constipation and irritable bowel syndrome with constipation in adults. By increasing chloride and water secretion into the intestines, it enhances intestinal motility and facilitates easier passage of stool. Lubiprostone also improves stool consistency and decreases abdominal discomfort.Side Effects
- Severe nausea or vomiting
- Trouble breathing
- Severe diarrhea, stomach pain or swelling
Warnings
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, low blood pressure, severe diarrhea, or a sudden change in bowel movements.
- This medicine may make you feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Prescription savings · · · ·
What is Lubiprostone ?
Lubiprostone is a chloride channel activator used primarily to treat chronic idiopathic constipation and irritable bowel syndrome with constipation in adults. By increasing chloride and water secretion into the intestines, it enhances intestinal motility and facilitates easier passage of stool. Lubiprostone also improves stool consistency and decreases abdominal discomfort.- Severe nausea or vomiting
- Trouble breathing
- Severe diarrhea, stomach pain or swelling
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Lightheadedness, dizziness, fainting
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, low blood pressure, severe diarrhea, or a sudden change in bowel movements.
- This medicine may make you feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Lubiprostone Coupons & Prices
Lubiprostone 24MCG
Lubiprostone is a prescription capsule used to treat certain types of chronic constipation. It's the generic form of the brand-name drug Amitiza, and because prices for lubiprostone can vary widely from pharmacy to pharmacy, it's worth comparing a lubiprostone coupon before you fill your prescription.
What Is Lubiprostone and How Does It Work?
Lubiprostone is a chloride channel activator taken as an oral capsule. It works locally in the small intestine to increase fluid secretion, which softens stool and helps it pass more easily. Lubiprostone is FDA-approved for chronic idiopathic constipation in adults, irritable bowel syndrome with constipation (IBS-C) in adult women 18 and older, and opioid-induced constipation in adults with chronic non-cancer pain.
Comparing Lubiprostone Prices
Lubiprostone is available as a generic, and generic prescription prices can vary a great deal depending on which pharmacy you use. Rx.com compares prices at more than 60,000 pharmacies so you can find the lowest cash price near you. Enter your ZIP above to see today's price at pharmacies in your area, and always check both your insurance copay and the cash price, since one is sometimes lower than the other.
Lubiprostone vs. Amitiza and Other Constipation Treatments
Lubiprostone is the generic equivalent of the brand-name capsule Amitiza. Other prescription options for chronic constipation work differently: Linzess (linaclotide) and Trulance (plecanatide) are guanylate cyclase-C agonists, while OTC options like MiraLax (polyethylene glycol 3350) work as an osmotic laxative. Your doctor can help decide which fits your specific diagnosis and symptoms.
Safety Information
- The most common side effects of lubiprostone include nausea, diarrhea, and abdominal pain; taking it with food may reduce nausea.
- Lubiprostone should not be used in patients with known or suspected mechanical gastrointestinal obstruction.
- Tell your doctor if you are pregnant or planning to become pregnant, since lubiprostone may cause fetal loss in some situations.
- This is not medical advice — talk with your doctor or pharmacist about whether lubiprostone is appropriate for your condition and any other medications you take.
This Lubiprostone information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.
Verify the official label: Lubiprostone on DailyMed (FDA)
Reviewed against FDA labeling · Last reviewed July 2026
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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.