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Mucinex

Mucinex 20 Tablets Extended Release 12 Hour

What is Mucinex?

Guaifenesin ER is a generic drug used to relieve coughs caused by the common cold, bronchitis, and other breathing illnesses. The cost for 60, 20 mg-400 mg Guaifenesin oral capsules, extended release is around $11. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.

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What is Mucinex ?

Guaifenesin ER is a generic drug used to relieve coughs caused by the common cold, bronchitis, and other breathing illnesses. The cost for 60, 20 mg-400 mg Guaifenesin oral capsules, extended release is around $11. Get savings of up to 80% when you use our free prescription coupon card at any participating pharmacy near you.
  • Cough that lasts longer than 7 days.
  • Cough with fever, skin rash, or ongoing headache.
  • This medicine may contain alcohol.
  • If you are pregnant or breast feeding, ask your doctor or pharmacist before using this medicine.
  • If your cough is caused by asthma, emphysema, bronchitis, or smoking, talk to your doctor before using this medicine.
What is the difference between Mucinex and Mucinex DM?
Plain Mucinex contains only guaifenesin, an expectorant that loosens and thins mucus to make a cough more productive. Mucinex DM adds dextromethorphan, a cough suppressant, making it intended for a cough that's both dry and productive rather than just chest congestion.
How long does it take for Mucinex to start working?
The label describes guaifenesin as working to loosen and thin mucus to make coughs more productive, but it doesn't specify an exact onset time. If your cough isn't improving or persists more than 7 days, or comes with fever, rash, or a persistent headache, check with a doctor.
Can you take Mucinex and Dayquil/Nyquil together?
Many cough and cold combination products, including some multi-symptom formulas, already contain overlapping ingredients like dextromethorphan or a decongestant, so combining products can risk doubling up on the same active ingredient. Check the Drug Facts label on both products for overlapping ingredients, and ask a pharmacist or doctor before combining them.
Is guaifenesin the same as Mucinex?
Yes. Guaifenesin is the generic active ingredient, and Mucinex is a brand name for it. Guaifenesin is also sold under other brand and store-brand names, including Mucinex Maximum Strength, Mucinex Fast-Max, Mucinex Children's, and Robitussin Chest Congestion.
How often can you take Mucinex safely?
Dosing frequency depends on the specific product and its strength (regular vs. extended-release, and whether it's combined with dextromethorphan or pseudoephedrine), so always follow the dosing instructions on that product's Drug Facts label. Extended-release tablets should be swallowed whole, not crushed, chewed, or split, and taken with a full glass of water.
How much does Mucinex cost without insurance?
The price of Mucinex without insurance varies by pharmacy, dosage, and quantity. Rx.com compares cash prices at more than 60,000 US pharmacies so you can find the lowest price near you.
What are the common side effects of Mucinex?
Common side effects of Mucinex may include: Cough that lasts longer than 7 days., Cough with fever, skin rash, or ongoing headache.. This is not a complete list — consult your pharmacist or doctor for full side effect information.
Is there a generic version of Mucinex?
Generic versions may be available for Mucinex. Generics contain the same active ingredients as brand-name drugs and are typically 80–90% cheaper. Search Mucinex on Rx.com to compare generic and brand prices at pharmacies near you.
What is the cheapest pharmacy for Mucinex?
The cheapest pharmacy for Mucinex depends on your location and dosage. Rx.com compares prices at CVS, Walgreens, Walmart, Kroger, Costco, and thousands of independent pharmacies. Enter your ZIP code on Rx.com to find the lowest price for Mucinex near you.

Mucinex Coupons & Prices

Mucinex 20 Tablets Extended Release 12 Hour

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No Prescription Needed

Mucinex is available over the counter — order online or pick up at a pharmacy near you.

Where to Buy Mucinex

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Available Over-the-Counter No prescription needed.
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Looking for a Mucinex coupon? Mucinex is a brand name for guaifenesin, an over-the-counter expectorant, and it's already sold as a lower-cost generic at most pharmacies — but what you actually pay can vary a lot from one pharmacy to the next. Rx.com compares prices for guaifenesin and Mucinex across more than 60,000 U.S. pharmacies, so enter your ZIP above to see today's price near you before you check out.

What is Mucinex and how does it work?

Mucinex is a brand name for guaifenesin, an expectorant (mucolytic) available over the counter. It's labeled to temporarily loosen phlegm and thin bronchial secretions so that coughs become more productive, for cough due to minor throat and bronchial irritation associated with the common cold. Guaifenesin doesn't treat the underlying infection or shorten how long a cold lasts — it simply helps clear mucus.

Combination versions extend what the product is used for: Mucinex DM adds dextromethorphan, a cough suppressant, for a dry-and-productive cough combination, while Mucinex D adds pseudoephedrine, a nasal decongestant, for congestion along with mucus. Guaifenesin is also sold under other brand and store names, including Mucinex Maximum Strength, Mucinex Fast-Max, Mucinex Children's, and Robitussin Chest Congestion.

Guaifenesin cost without insurance

Guaifenesin, the generic behind Mucinex, is widely available, and generic guaifenesin products exist alongside the various Mucinex brand formulations. Because it's sold over the counter, price isn't standardized — what one pharmacy charges for a box of guaifenesin or a Mucinex product can differ noticeably from what another pharmacy down the street charges, and that gap is easy to miss if you only check one store.

That's where comparing pays off. Enter your ZIP code above and Rx.com will show you current pricing across pharmacies near you, so you can see where the better price is before you buy — whether you're picking up generic guaifenesin or a specific Mucinex formulation.

Mucinex vs. Mucinex DM, Mucinex D, and other cough/cold options

Plain Mucinex (guaifenesin only) is aimed at loosening and thinning mucus so a cough is more productive. Mucinex DM adds dextromethorphan, a cough suppressant, which is a different job — it's meant for a cough that's dry as well as productive. Mucinex D adds pseudoephedrine, a decongestant, for nasal/sinus congestion alongside chest congestion. Picking the right one depends on which symptoms you actually have, and reading the Drug Facts label on the box is the best way to confirm which active ingredients are in a given product.

If your main symptom is a suppressed dry cough rather than chest congestion, a dextromethorphan-only product may fit better; if congestion is the main issue, a pseudoephedrine-containing product may be more appropriate. You can compare related options, including dextromethorphan, pseudoephedrine, Robitussin, benzonatate, and Delsym, on Rx.com.

Safety information

Mucinex (guaifenesin) is generally well tolerated, with no FDA boxed warning. The most common side effects are mild: nausea, vomiting, stomach upset, dizziness, or headache. It isn't recommended for children under 4 (check the specific product's age limit on the label), and extended-release tablets must be swallowed whole with a full glass of water — not crushed, chewed, or split.

If you're taking a combination product, be aware that Mucinex D's pseudoephedrine carries cautions for people with high blood pressure, heart disease, thyroid disease, or diabetes, and shouldn't be combined with MAOIs; Mucinex DM's dextromethorphan also shouldn't be combined with MAOIs and can be misused at high doses. Ask a doctor before use if your cough lasts more than 7 days, comes back, or is accompanied by fever, rash, or a persistent headache, since that can point to something that needs a closer look. This information isn't a substitute for medical advice — talk to your doctor or pharmacist about what's right for you.

Sources & accuracy

This Mucinex information was written and reviewed against authoritative U.S. medical sources — MedlinePlus (U.S. National Library of Medicine), DailyMed, and FDA prescribing information — and checked for accuracy. It is provided for education and is not a substitute for professional medical advice.

Verify the official label: Mucinex on DailyMed (FDA)

Reviewed against FDA labeling · Last reviewed July 2026

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Medical disclaimer: This information is provided for general educational purposes only and is not medical advice. It is not a substitute for professional diagnosis or treatment. Always consult a licensed physician, pharmacist, or other qualified healthcare provider before starting, stopping, or changing any medication or treatment. Never disregard professional medical advice or delay seeking it because of something you read here. If you think you may have a medical emergency, call your doctor or 911 immediately.